Exceptional Variant with Distant Cutaneous Metastasis as the First Clinical Sign in Gastric Signet-Ring Carcinoma

2021 ◽  
Author(s):  
Ezgi Bulut ◽  
Ebru Taştekin ◽  
Canberk Topuz ◽  
Sevgi Öztürk ◽  
Ali Gökyer
Keyword(s):  
Clinical Sign ◽  
Cutaneous Metastasis ◽  
Signet Ring ◽  
Signet Ring Carcinoma

Histomorphologic Assessment of Formalin Substitute Fixatives for Diagnostic Surgical Pathology

2005 ◽  
Vol 129 (4) ◽  
pp. 502-506 ◽  
Author(s):  
Michael E. Titford ◽  
Marcelo G. Horenstein
Keyword(s):  
Myxoid Liposarcoma ◽  
The United States ◽  
Surgical Pathology ◽  
Blind Study ◽  
Endometrioid Adenocarcinoma ◽  
Follicular Hyperplasia ◽  
Signet Ring ◽  
Laboratory Workers ◽  
Hematoxylin Eosin ◽  
Signet Ring Carcinoma

Abstract Context.—In 1987, the Formaldehyde Standard became law in the United States, alerting laboratory workers to the potential carcinogenicity of formaldehyde. As a result, a variety of proprietary fixatives were developed for use in surgical pathology. Objective.—To assess histomorphology with different formalin substitute fixatives. Design.—Four experienced board-certified surgical pathologists examined 7 specimens (hepatocellular carcinoma, ovarian sex cord/stromal tumor, myxoid liposarcoma, uterine endometrioid adenocarcinoma, splenic follicular hyperplasia, infiltrating mammary carcinoma, and cecal signet ring carcinoma) fixed with formalin and 5 proprietary fixatives advertised as formalin replacements. In a blind study, the pathologists rated cellular outlines, cytoplasmic detail, nuclear detail, erythrocyte integrity, lymphocyte integrity, overall morphology, and overall staining in each case. Results.—Formalin received the highest overall morphology and staining scores, followed by Glyo-Fixx, STF-Streck, Omnifix, Histochoice, and Histofix. Formalin also received the highest scores in cellular outline and erythrocyte integrity. Individually, some fixatives performed better in different areas than others. Glyo-Fixx performed as well as formalin for overall morphology and provided highest nuclear detail and lymphocyte appearance scores. Omnifix II gave best results for cytoplasmic detail. Conclusion.—In this blind study, formalin fixation provided the highest histomorphologic quality for tissue stained with hematoxylin-eosin and examined for diagnostic surgical pathology. Should the use of formalin be discontinued, pathologists will have to familiarize themselves with a different set of microscopic details associated with the replacement fixatives.

Mucinous (Noncystic) Adenocarcinoma, Including Signet-Ring Carcinoma

1994 ◽  
pp. 155-158
Author(s):  
Parviz M. Pour ◽  
Yoichi Konishi ◽  
Günter Klöppel ◽  
Daniel S. Longnecker
Keyword(s):  
Signet Ring ◽  
Signet Ring Carcinoma

scholarly journals Ovarian Mixed Malignant Brenner-Mucinous Tumor with Signet Ring Cells

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Baharak Khadang ◽  
Atilla Omeroglu
Keyword(s):  
Ovarian Carcinoma ◽  
Mucinous Tumor ◽  
Signet Ring Cells ◽  
Brenner Tumor ◽  
Signet Ring ◽  
Signet Ring Carcinoma

Mucinous carcinomas with signet ring cells in the ovary, particularly those composed predominantly of signet ring cells, are extremely rare, and in vast majority of cases, they represent metastasis from another site such as the stomach, appendix, pancreaticobiliary tract, bladder, and breast (Hristov et al., 2007, Kiyokawa et al., 2006, Vang et al., 2006, Young, 2006). Malignant Brenner tumor is also rare comprising less than 0.5% of ovarian carcinoma. Although mixed Brenner-Mucinous tumors are relatively common, the combination of a primary ovarian signet ring carcinoma with a malignant Brenner tumor is unique and to the best of our knowledge not previously reported in the literature.

Primary signet ring carcinoma of the colon and rectum

1995 ◽  
Vol 26 (4) ◽  
pp. 378-379 ◽  
Author(s):  
N.H.H. NADHA SARMA ◽  
L.D. GAHUKAMBLE ◽  
R.N. VISWESWARA ◽  
K. RAMESH ◽  
O. AL FITURI ◽  
...  
Keyword(s):  
Carcinoma Of The Colon ◽  
Signet Ring ◽  
Colon And Rectum ◽  
Signet Ring Carcinoma

Signet-ring cell carcinoma in gastric biopsies: expecting the unexpected

2012 ◽  
Vol 66 (2) ◽  
pp. 136-139 ◽  
Author(s):  
Christopher P Golembeski ◽  
Robert Maximilian Genta
Keyword(s):  
Signet Ring Cell ◽  
Gastric Biopsy ◽  
Intestinal Type ◽  
Ring Type ◽  
Signet Ring ◽  
Ambulatory Patients ◽  
Gastric Biopsies ◽  
Ring Cell ◽  
Primary Gastric Carcinoma ◽  
Signet Ring Carcinoma

AimsThis study was designed to establish the relative prevalence of intestinal-type and signet-ring carcinoma in gastric biopsy specimens from ambulatory patients, to determine the percentage of signet-ring carcinomas that could be expected based on the available clinical and endoscopic information, and to estimate the likelihood of missing a tumour.MethodsWe extracted data of all patients with a diagnosis of primary gastric carcinoma from a national pathology database. We then reviewed clinical information and original slides, classified tumours as intestinal or signet-ring-type, and categorised the latter as ‘unexpected’ (no alarming symptoms, no mention of suspicious lesions) or ‘expected’ (clinical or endoscopic information suggestive of tumour). Unexpected signet-ring carcinomas were categorised as ‘obvious’ or ‘challenging’ (rare signet-ring cells; immunohistochemical stains used to confirm the nature of the infiltrates).ResultsThere were 310 109 patients with gastric biopsies; 615 patients had primary gastric carcinoma (359 intestinal and 256 signet-ring-type). Gastric cancer was more common in men (OR 2.54; 95% CI 2.05 to 3.14; p<.0001) for intestinal-type and (OR 1.90; 95% CI 1.48 to 2.42; p<0.0001) for signet-ring cell type). Intestinal-type carcinoma occurred in older patients than signet-ring-type (median age 74 vs 65 years, p<0.001). There were 196 expected and 60 unexpected signet-ring carcinomas; 47 of the 60 unexpected cases were histopathologically obvious. Thus, only 13 signet-ring carcinomas (1 in 25 000 gastric biopsy sets) were truly unexpected.ConclusionsSignet-ring carcinoma is a rare finding in gastric biopsy specimens from ambulatory patients; routine due diligence and the clinical/endoscopic information provided are usually adequate to raise pathologists’ index of suspicion.

scholarly journals Cutaneous metastasis of signet ring cell appendiceal adenocarcinoma: a herald of disease recurrence

2020 ◽  
Vol 6 (3) ◽  
pp. 406
Author(s):  
Jennifer L. Seyffert ◽  
Nathan Bibliowicz ◽  
Christopher Wong ◽  
Michael Wangia
Keyword(s):  
Poor Prognosis ◽  
Rare Case ◽  
Disease Recurrence ◽  
Cutaneous Metastasis ◽  
Signet Ring Cell ◽  
Rare Entity ◽  
High Tendency ◽  
Appendiceal Adenocarcinoma ◽  
Signet Ring ◽  
Ring Cell

<p>Signet ring cell appendiceal adenocarcinoma (SRCAA) is a rare entity with poor prognosis and high tendency for metastasis to pelvic lymph nodes, ovaries, and peritoneal surfaces. Despite numerous reports of intra-abdominal metastasis, there have been few reported cases of cutaneous SRCAA metastasis. We report a rare case of SRCAA metastatic to the cutaneous abdominal wall in a 67 years old female, which was first presenting sign of disease recurrence.</p>

scholarly journals Report of a Case of Signet Ring Carcinoma Presenting as Gastric Mucosal Thickening: A Diagnostic Dilemma

2021 ◽  
Vol 9 (1) ◽  
pp. 120-124
Author(s):  
Cumali KARATOPRAK ◽  
Adem AKÇAKAYA ◽  
Hakan ŞENTÜRK ◽  
Ganime ÇOBAN ◽  
Nurhan ŞAHİN ◽  
...  
Keyword(s):  
Diagnostic Dilemma ◽  
Signet Ring ◽  
Mucosal Thickening ◽  
Signet Ring Carcinoma
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