Comparative Outcomes of Second-line Topoisomerase-I Inhibitor Therapies on Neuroendocrine Carcinoma

2022 ◽  
Author(s):  
Ho-Man Yeung ◽  
Krishnalatha Sreekrishnanilayam ◽  
Caitlin Meeker ◽  
Mengying Deng ◽  
Sonali Agrawal ◽  
...  
Keyword(s):  
Neuroendocrine Carcinoma ◽  
Topoisomerase I ◽  
Second Line ◽  
Topoisomerase I Inhibitor

A Case of Duodenal Neuroendocrine Carcinoma Treated with Amrubicin as Second-line Chemotherapy

2015 ◽  
Vol 24 (3) ◽  
pp. 379-382
Author(s):  
Tadahisa Inoue ◽  
Hitoshi Sano ◽  
Takashi Mizushima ◽  
Hirotada Nishie ◽  
Hiroyasu Iwasaki ◽  
...  
Keyword(s):  
Neuroendocrine Carcinoma ◽  
Distant Metastases ◽  
Salvage Chemotherapy ◽  
Second Line ◽  
Effective Treatment Option ◽  
Second Line Chemotherapy ◽  
Best Response ◽  
Long Term Effect ◽  
Line Chemotherapy

We present the case of a Japanese man in his 60s with duodenal neuroendocrine carcinoma with distant metastases. Chemotherapy with irinotecan plus cisplatin was initiated as a first-line regimen. However, disease progression was observed after only two cycles. Therefore, amrubicin was administered as a second-line chemotherapy. The patient showed a long-term effect of amrubicin therapy, and the best response was a partial response after seven cycles. For duodenal neuroendocrine carcinoma, amrubicin therapy can be considered an effective treatment option as salvage chemotherapy.

Pharmacokinetics, tissue distribution, and metabolism of novel DNA topoisomerase I inhibitor yuanhuacine in rabbit

Xenobiotica ◽  
2009 ◽  
Vol 39 (3) ◽  
pp. 273-281 ◽  
Author(s):  
S. X. Zhang ◽  
P. W. Yang ◽  
D. C. Zhang ◽  
W. Q. Dong ◽  
F. H. Zhang ◽  
...  
Keyword(s):  
Tissue Distribution ◽  
Topoisomerase I ◽  
Dna Topoisomerase I ◽  
Dna Topoisomerase ◽  
Topoisomerase I Inhibitor

Isodiospyrin as a novel human DNA topoisomerase I inhibitor

2003 ◽  
Vol 66 (10) ◽  
pp. 1981-1991 ◽  
Author(s):  
Chun-Yuan Ting ◽  
Chia-Tse Hsu ◽  
Hsiang-Ting Hsu ◽  
Jin-Shan Su ◽  
Tzong-Yueh Chen ◽  
...  
Keyword(s):  
Topoisomerase I ◽  
Dna Topoisomerase I ◽  
Dna Topoisomerase ◽  
Topoisomerase I Inhibitor ◽  
Human Dna ◽  
Human Dna Topoisomerase I

Wide application of a novel topoisomerase I inhibitor-based drug conjugation technology

2016 ◽  
Vol 26 (20) ◽  
pp. 5069-5072 ◽  
Author(s):  
Yusuke Ogitani ◽  
Yuki Abe ◽  
Takuma Iguchi ◽  
Junko Yamaguchi ◽  
Tomoko Terauchi ◽  
...  
Keyword(s):  
Topoisomerase I ◽  
Topoisomerase I Inhibitor ◽  
Drug Conjugation
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