Hepatitis B virus genotype C encoding resistance mutations that emerge during adefovir dipivoxil therapy: in vitro replication phenotype

2012 ◽  
Vol 7 (2) ◽  
pp. 443-450 ◽  
Author(s):  
Wenpeng Li ◽  
Nadia Warner ◽  
Vitina Sozzi ◽  
Lilly Yuen ◽  
Danni Colledge ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Adefovir Dipivoxil ◽  
Resistance Mutations ◽  
Virus Genotype ◽  
In Vitro Replication ◽  
B Virus ◽  
Genotype C

Efficacy of adefovir dipivoxil in the treatment of lamivudine-resistant hepatitis B virus genotype C infection

2007 ◽  
Vol 27 (1) ◽  
Author(s):  
Do Young Kim ◽  
Hong Jeoung Kim ◽  
Chun Kyon Lee ◽  
Jeong Hun Suh ◽  
Dong Hwan Kim ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Adefovir Dipivoxil ◽  
Virus Genotype ◽  
B Virus ◽  
Genotype C

Virological Response and Hepatocarcinogenesis in Lamivudine-Resistant Hepatitis B Virus Genotype C Patients Treated with Lamivudine plus Adefovir Dipivoxil

Intervirology ◽  
2008 ◽  
Vol 51 (6) ◽  
pp. 385-393 ◽  
Author(s):  
Norio Akuta ◽  
Fumitaka Suzuki ◽  
Yusuke Kawamura ◽  
Hiromi Yatsuji ◽  
Hitomi Sezaki ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Virological Response ◽  
Adefovir Dipivoxil ◽  
Virus Genotype ◽  
B Virus ◽  
Genotype C

Permissive, in vitro replication of hepatitis B virus genotype E

2017 ◽  
Vol 243 ◽  
pp. 20-24
Author(s):  
Xin Ji ◽  
Mohammad Zafrullah ◽  
Nicholas Wiese ◽  
Tonya Hayden-Mixon ◽  
Joseph C. Forbi ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Virus Genotype ◽  
In Vitro Replication ◽  
B Virus ◽  
Genotype E

Predominance of hepatitis B virus genotype C among Karens, the ‘old settlers’ of Andaman and Nicobar Islands, India

2007 ◽  
Vol 152 (6) ◽  
pp. 1223-1228 ◽  
Author(s):  
S. Datta ◽  
P. K. Chandra ◽  
A. Banerjee ◽  
R. Chakravarty ◽  
K. M. Murhekar ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Andaman And Nicobar Islands ◽  
Virus Genotype ◽  
B Virus ◽  
Genotype C ◽  
Nicobar Islands

scholarly journals Distinct Distribution Pattern of Hepatitis B Virus Genotype C and D in Liver Tissue and Serum of Dual Genotype Infected Liver Cirrhosis and Hepatocellular Carcinoma Patients

PLoS ONE ◽  
2014 ◽  
Vol 9 (7) ◽  
pp. e102573 ◽  
Author(s):  
Somenath Datta ◽  
Shrabasti Roychoudhury ◽  
Alip Ghosh ◽  
Debanjali Dasgupta ◽  
Amit Ghosh ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Cirrhosis ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Liver Tissue ◽  
Virus Genotype ◽  
B Virus ◽  
Infected Liver ◽  
Genotype C ◽  
Distinct Distribution

scholarly journals High prevalence of hepatitis B virus genotype C/C1 in the Minangkabau ethnic group in Indonesia

2013 ◽  
Vol 10 (1) ◽  
pp. 27 ◽  
Author(s):  
Marlinang D Siburian ◽  
Andi Utama ◽  
Rama Dhenni ◽  
null Arnelis ◽  
Ismail Fanany ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Ethnic Group ◽  
Virus Genotype ◽  
B Virus ◽  
High Prevalence ◽  
Genotype C

scholarly journals Another novel subgenotype of hepatitis B virus genotype C from papuans of Highland origin

2010 ◽  
Vol 83 (2) ◽  
pp. 225-234 ◽  
Author(s):  
Juniastuti ◽  
Takako Utsumi ◽  
Victor Eka Nugrahaputra ◽  
Mochamad Amin ◽  
Soetjipto ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Virus Genotype ◽  
B Virus ◽  
Genotype C

The Putative Recombination of Hepatitis B Virus Genotype B with Pre-C/C Region of Genotype C

Virus Genes ◽  
2004 ◽  
Vol 29 (1) ◽  
pp. 31-41 ◽  
Author(s):  
Kangxian Luo ◽  
Zhihua Liu ◽  
Haitang He ◽  
Jie Peng ◽  
Weifang Liang ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Virus Genotype ◽  
B Virus ◽  
Genotype C

scholarly journals An Adult Patient with Acute Infection with Hepatitis B Virus Genotype C that Progressed to Chronic Infection

2012 ◽  
Vol 51 (2) ◽  
pp. 173-176 ◽  
Author(s):  
Toru Miyoshi ◽  
Atsushi Hiraoka ◽  
Satoshi Hidaka ◽  
Yuko Shimizu ◽  
Keiko Ninomiya ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Adult Patient ◽  
Chronic Infection ◽  
Acute Infection ◽  
Virus Genotype ◽  
B Virus ◽  
Genotype C

scholarly journals Efficacies of Entecavir against Lamivudine-Resistant Hepatitis B Virus Replication and Recombinant Polymerases In Vitro

2002 ◽  
Vol 46 (8) ◽  
pp. 2525-2532 ◽  
Author(s):  
S. Levine ◽  
D. Hernandez ◽  
G. Yamanaka ◽  
S. Zhang ◽  
R. Rose ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Cross Resistance ◽  
Wild Type ◽  
Resistance Mutations ◽  
Hbv Replication ◽  
B Virus ◽  
Inhibition Studies

ABSTRACT Entecavir (ETV) is a potent and selective inhibitor of hepatitis B virus (HBV) replication in vitro and in vivo that is currently in clinical trials for the treatment of chronic HBV infections. A major limitation of the current HBV antiviral therapy, lamivudine (3TC), is the emergence of drug-resistant HBV in a majority of treated patients due to specific mutations in the nucleotide binding site of HBV DNA polymerase (HBV Pol). To determine the effects of 3TC resistance mutations on inhibition by ETV triphosphate (ETV-TP), a series of in vitro studies were performed. The inhibition of wild-type and 3TC-resistant HBV Pol by ETV-TP was measured using recombinant HBV nucleocapsids, and compared to that of 3TC-TP. These enzyme inhibition studies demonstrated that ETV-TP is a highly potent inhibitor of wild-type HBV Pol and is 100- to 300-fold more potent than 3TC-TP against 3TC-resistant HBV Pol. Cell culture assays were used to gauge the potential for antiviral cross-resistance of 3TC-resistant mutants to ETV. Results demonstrated that ETV inhibited the replication of 3TC-resistant HBV, but 20- to 30-fold higher concentrations were required. To gain further perspective regarding the potential therapeutic use of ETV, its phosphorylation was examined in hepatoma cells treated with extracellular concentrations representative of drug levels in plasma in ETV-treated patients. At these concentrations, intracellular ETV-TP accumulated to levels expected to inhibit the enzyme activity of both wild-type and 3TC-resistant HBV Pol. These findings are predictive of potent antiviral activity of ETV against both wild-type and 3TC-resistant HBV.

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