Circulating tumoral cells lack circadian-rhythm in hospitalized metastasic breast cancer patients

2006 ◽  
Vol 8 (11) ◽  
pp. 826-829 ◽  
Author(s):  
José Ángel García-Sáenz ◽  
Miguel Martin ◽  
Marisa Maestro ◽  
Marta Vidaurreta ◽  
Silvia Veganzones ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Circadian Rhythm ◽  
Cancer Patients ◽  
Breast Cancer Patients ◽  
Tumoral Cells

Weak circadian rhythm increases neutropenia risk among breast cancer patients undergoing adjuvant chemotherapy

2017 ◽  
Vol 168 (2) ◽  
pp. 483-493 ◽  
Author(s):  
Wentao Li ◽  
Carol Chi-Hei Kwok ◽  
Dominic Chun-Wan Chan ◽  
Feng Wang ◽  
Lap Ah Tse
Keyword(s):  
Breast Cancer ◽  
Circadian Rhythm ◽  
Adjuvant Chemotherapy ◽  
Cancer Patients ◽  
Breast Cancer Patients

Temporal interrelationships among fatigue, circadian rhythm and depression in breast cancer patients undergoing chemotherapy treatment

2001 ◽  
Vol 10 (4) ◽  
pp. 329-336 ◽  
Author(s):  
Joseph A. Roscoe ◽  
Gary R. Morrow ◽  
Jane T. Hickok ◽  
Peter Bushunow ◽  
Sara Matteson ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Circadian Rhythm ◽  
Cancer Patients ◽  
Breast Cancer Patients ◽  
Chemotherapy Treatment

The circadian rhythm of biochemical markers of bone resorption is normally synchronized in breast cancer patients with bone lytic metastases independently of tumor load

Bone ◽  
2007 ◽  
Vol 40 (1) ◽  
pp. 182-188 ◽  
Author(s):  
Daniele Generali ◽  
Alfredo Berruti ◽  
Marco Tampellini ◽  
Andrea Dovio ◽  
Sara Tedoldi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Circadian Rhythm ◽  
Bone Resorption ◽  
Cancer Patients ◽  
Biochemical Markers ◽  
Breast Cancer Patients ◽  
Tumor Load ◽  
Markers Of Bone Resorption

Circadian rhythm of bone turnover markers in breast cancer patients with bone metastases and in control subjects

2005 ◽  
Vol 23 (16_suppl) ◽  
pp. 737-737 ◽  
Author(s):  
D. G. Generali ◽  
S. Tedoldi ◽  
M. Tampellini ◽  
A. Berruti ◽  
M. Torta ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Circadian Rhythm ◽  
Bone Turnover ◽  
Bone Metastases ◽  
Cancer Patients ◽  
Bone Turnover Markers ◽  
Breast Cancer Patients ◽  
Control Subjects ◽  
Turnover Markers

Circadian rhythm and concentration of melatonin in breast cancer patients

2020 ◽  
Vol 20 ◽  
Author(s):  
Hanan Ahabrach ◽  
Nisrin El Mlili ◽  
Mohammed Errami ◽  
Omar Cauli
Keyword(s):  
Breast Cancer ◽  
Circadian Rhythm ◽  
Circadian Rhythms ◽  
Cancer Patients ◽  
Psychological Symptoms ◽  
Breast Cancers ◽  
Breast Cancer Patients ◽  
Melatonin Secretion ◽  
Breast Cancer Chemotherapy ◽  
Post Operation

Background: Melatonin is a biomarker of the central circadian clock and its chronobiotic actions entraining circadian rhythms to the light-dark cycle are well known. Reduction in melatonin levels and altered circadian rhythms have been associated with a high risk of breast cancer. Melatonin has also shown to display anti-proliferative effects on breast cancer growth and proliferation. Evaluation of melatonin circadian rhythm alterations in patients bearing breast cancer may have interesting prognostic and therapeutic applications. Objective: To review studies evaluating the circadian rhythm of melatonin in breast cancer patients. The effects of surgery and chemotherapy on melatonin secretion were also reviewed. Methods: Electronic databases including PubMed/MEDLINE and Scopus were searched from their inception to May 2020, using the keywords "Melatonin", "Circadian rhythm" and "Breast cancer". Result: Patients with breast cancer maintain a circadian rhythm of melatonin secretion with relatively high levels during the night, and low levels during the day however a reduction of nocturnal melatonin peak and decreased amplitude of melatonin circadian rhythms in these patients have been also reported. Melatonin levels can influence estrogen receptor concentrations in hormone-dependent estrogen-positive breast cancer. Chemotherapy alters melatonin levels, and breast surgery tends to alter melatonin secretion at first day post-operation. Melatonin levels correlate with clinical and psychological symptoms of breast cancer, such as sleep quality and depression severity. Conclusion: Circadian rhythm and the concentration of melatonin in blood are altered in patients with breast cancers and it can modify not only sleep-wake cycle and thus patients’ quality of life but due to melatonin’s antioxidant effects is can modulated the effect of therapies. Due to the heterogonous protocols used to assess melatonin and variable environmental factors during sampling, further studies need to control such variables in order to tailor clinical trial based on melatonin rhythm adjustment and/or supplementation in breast cancer patients.

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