scholarly journals Incidental MALT Type Lymphoma Exhibiting Prominent Plasma Cell Differentiation Associated with Hashimoto’s Thyroiditis. A Two Case Report

2008 ◽  
Vol 3 (1) ◽  
Author(s):  
Masaru Kojima ◽  
Ken Shimizu ◽  
Kazuhiko Shimizu ◽  
Nobuhide Masawa
Keyword(s):  
Case Report ◽  
Cell Differentiation ◽  
Plasma Cell ◽  
Hashimoto’S Thyroiditis ◽  
Hashimoto's Thyroiditis ◽  
Plasma Cell Differentiation ◽  
Malt Type Lymphoma

Nodal marginal zone B-cell lymphoma showing prominent plasma cell differentiation in the pleural effusion: A case report

2012 ◽  
Vol 42 (2) ◽  
pp. 189-191
Author(s):  
Masaru Kojima ◽  
Yoshimasa Nakazato ◽  
Show Shiino ◽  
Yuko Kaneko ◽  
Kaoru Hirabayashi ◽  
...  
Keyword(s):  
Case Report ◽  
Cell Differentiation ◽  
Pleural Effusion ◽  
B Cell ◽  
Plasma Cell ◽  
Marginal Zone ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Plasma Cell Differentiation

scholarly journals Case Report: Familial Hypocalciuric Hypercalcaemia and Hashimoto's Thyroiditis

2020 ◽  
Vol 7 ◽  
Author(s):  
Shahd Mobarak ◽  
Munir Tarazi ◽  
Harry Spiers ◽  
Anjali Santhakumar ◽  
Bence Forgacs
Keyword(s):  
Case Report ◽  
Hashimoto’S Thyroiditis ◽  
Hashimoto's Thyroiditis

scholarly journals Efficient Plasma Cell Differentiation and Trafficking Require Cxcr4 Desensitization

Cell Reports ◽  
2016 ◽  
Vol 17 (1) ◽  
pp. 193-205 ◽  
Author(s):  
Vincent Biajoux ◽  
Jessica Natt ◽  
Christelle Freitas ◽  
Nagham Alouche ◽  
Antoine Sacquin ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Plasma Cell ◽  
Plasma Cell Differentiation

Genomic deletion of the whole IgH 3′ regulatory region (hs3a, hs1,2, hs3b, and hs4) dramatically affects class switch recombination and Ig secretion to all isotypes

Blood ◽  
2010 ◽  
Vol 116 (11) ◽  
pp. 1895-1898 ◽  
Author(s):  
Christelle Vincent-Fabert ◽  
Remi Fiancette ◽  
Eric Pinaud ◽  
Véronique Truffinet ◽  
Nadine Cogné ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
B Cells ◽  
Plasma Cell ◽  
Regulatory Region ◽  
Class Switch Recombination ◽  
B Cell Differentiation ◽  
Plasma Cell Differentiation ◽  
Heavy Chains ◽  
Class Switch ◽  
Transcriptional Changes

Abstract The immunoglobulin heavy chain locus (IgH) undergoes multiple changes along B-cell differentiation. In progenitor B cells, V(D)J assembly allows expression of μ heavy chains. In mature B cells, class switch recombination may replace the expressed constant (C)μ gene with a downstream CH gene. Finally, plasma cell differentiation strongly boosts IgH transcription. How the multiple IgH transcriptional enhancers tune these changes is unclear. Here we demonstrate that deletion of the whole IgH 3′ regulatory region (3′RR) allows normal maturation until the stage of IgM/IgD expressing lymphocytes, but nearly abrogates class switch recombination to all CH genes. Although plasma cell numbers are unaffected, we reveal the role of the 3′RR into the transcriptional burst normally associated with plasma cell differentiation. Our study shows that transcriptional changes and recombinations occurring after antigen-encounter appear mainly controlled by the 3′RR working as a single functional unit.

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