Head and neck Langerhans cell histiocytosis: two case reports and review of the literature

2019 ◽  
Vol 12 (3) ◽  
pp. 278-283
Author(s):  
Ilson Sepúlveda ◽  
Ignacio Mendoza ◽  
Romina Novoa ◽  
Geraldine Ayres ◽  
Nadia Inostroza ◽  
...  
Keyword(s):  
Head And Neck ◽  
Langerhans Cell Histiocytosis ◽  
Case Reports ◽  
Langerhans Cell ◽  
Review Of The Literature

LANGERHANS CELL HISTIOCYTOSIS: TWO CASE REPORTS IN ADULTS AND REVIEW OF THE LITERATURE

2010 ◽  
Vol 65 (5) ◽  
pp. 345-349 ◽  
Author(s):  
L. Decoster ◽  
K. De Braekeleer ◽  
C. Bourgain ◽  
D. Schallier
Keyword(s):  
Langerhans Cell Histiocytosis ◽  
Case Reports ◽  
Langerhans Cell ◽  
Review Of The Literature

scholarly journals Unusual sites of bone involvement in Langerhans cell histiocytosis: a systematic review of the literature

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Nahid Reisi ◽  
Pouran Raeissi ◽  
Touraj Harati Khalilabad ◽  
Alireza Moafi
Keyword(s):  
Systematic Review ◽  
Dendritic Cells ◽  
Rare Disease ◽  
Langerhans Cell Histiocytosis ◽  
Case Reports ◽  
Langerhans Cell ◽  
The Other ◽  
Bone Involvement ◽  
Intracranial Extension ◽  
Pathologic Fractures

Abstract Background Langerhans cell histiocytosis (LCH) is a rare disease that originates from the uncontrolled proliferation and accumulation of bone marrow-derived immature myeloid dendritic cells. Dendritic cells are a type of histiocyte that play an important role in the human immune system and are found in the bone, skin, stomach, eyes, intestines, and lungs. Objective This systematic review aimed to collect and report published case reports of rare bone disease caused by LCH to avoid misdiagnoses or delays in diagnosis. Methods We systematically searched Scopus, PubMed, Embase, and Web of Sciences from August 1, 2000 to December 31, 2019. Studies reporting cases of LCH with rare bone involvement were included. Results We identified 60 articles including 64 cases. Of the identified cases, 31 (48.4%) involved children, and 33 (51.6%) involved adults. Additionally, 46.9% (30 individuals) were from Asian countries. The mean age of the children was 7.6 ± 4.3 years and that of the adults was 36 ± 12 years. The findings indicated that unifocal bone involvements were the most prevalent form of the disease (68.7%), and, overall, the skull and chest wall were the most commonly affected bones in both adults and children. The spine and long bones were the second most commonly affected bones in children, and the spine and jaw were the second most commonly affected bones in adults. Pain and swelling were the most frequent presenting signs among the investigated cases, and loss of consciousness, myelopathy, nerve palsy, visual loss, torticollis and clicking sounds were rare signs. Osteolytic lesions were the most frequent radiologic feature (62.5%), and intracranial hemorrhage, fluid–fluid level, dura and intracranial extension and pathologic fractures were rare radiological features. Total excision, curettage and observation in the unifocal group of patients and systemic chemotherapy in the other groups (i.e., multifocal and multisystem) were the most frequent management approaches. The recovery rates of the unifocal and multifocal groups were 77.3% and 81.8%, respectively, while that of the multisystem group was 55.5%. The rates of recurrence and mortality in the multisystem group were 11% and were higher than those in the other groups. Conclusions LCH is a rare disease that can affect any organ in the human body. However, bone is the most commonly involved organ, and rare bone involvements may be the first or only symptom of the disease due to the rarity of such lesions; a lack of familiarity with them may result in misdiagnosis or delayed diagnosis.

Liver Transplantation for Langerhans Cell Histiocytosis: A U.S. Population‐Based Analysis and Systematic Review of the Literature

2021 ◽  
Author(s):  
Ioannis A. Ziogas ◽  
Christos D. Kakos ◽  
W. Kelly Wu ◽  
Martin I. Montenovo ◽  
Lea K. Matsuoka ◽  
...  
Keyword(s):  
Systematic Review ◽  
Liver Transplantation ◽  
Langerhans Cell Histiocytosis ◽  
Population Based ◽  
Langerhans Cell ◽  
Review Of The Literature

scholarly journals Unifocal Granuloma of Femur due to Langerhans' Cell Histiocytosis: A Case Report and Review of the Literature

2010 ◽  
Vol 2010 ◽  
pp. 1-3 ◽  
Author(s):  
Harpreet Singh ◽  
Satnam Kaur ◽  
P. Yuvarajan ◽  
Nishant Jain ◽  
Lalit Maini
Keyword(s):  
Case Report ◽  
Clinical Data ◽  
Case History ◽  
Langerhans Cell Histiocytosis ◽  
Eosinophilic Granuloma ◽  
Pediatric Population ◽  
Langerhans Cell ◽  
Long Bones ◽  
Review Of The Literature ◽  
Osteolytic Lesions

The radiological diagnosis of osteolytic lesions of the long bones in pediatric population constitutes a challenge when the case history and clinical data are uncharacteristic. We believe that the description of few clinically and histologically proven cases to verify the existence of radiological signs useful for diagnosis may be of interest. Here, we describe a case of Langerhans' cell histiocytosis (LCH) presenting as unifocal eosinophilic granuloma of femur along with a brief review of the literature.

scholarly journals Vemurafenib in Langerhans cell histiocytosis: report of a pediatric patient and review of the literature

Oncotarget ◽  
2018 ◽  
Vol 9 (31) ◽  
pp. 22236-22240 ◽  
Author(s):  
Anne Heisig ◽  
Jan Sörensen ◽  
Stefanie-Yvonne Zimmermann ◽  
Stefan Schöning ◽  
Dirk Schwabe ◽  
...  
Keyword(s):  
Pediatric Patient ◽  
Langerhans Cell Histiocytosis ◽  
Langerhans Cell ◽  
Review Of The Literature

Langerhans Cell Histiocytosis of the Thyroid: A Report of Two Cases and Review of the Literature

Thyroid ◽  
2001 ◽  
Vol 11 (7) ◽  
pp. 697-705 ◽  
Author(s):  
Robert J. Behrens ◽  
Angelique W. Levi ◽  
William H. Westra ◽  
Deepa Dutta ◽  
David S. Cooper
Keyword(s):  
Langerhans Cell Histiocytosis ◽  
Langerhans Cell ◽  
Review Of The Literature

scholarly journals An unusual case of intracerebral Non-Langerhans cell histiocytosis with review of the literature

2007 ◽  
Vol 2 (Suppl 1) ◽  
pp. S24
Author(s):  
K Mueller ◽  
M Trippel ◽  
A Berlis ◽  
W Janzarik ◽  
B Volk
Keyword(s):  
Langerhans Cell Histiocytosis ◽  
Unusual Case ◽  
Langerhans Cell ◽  
Review Of The Literature
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