Synthesis and biological evaluation of some novel urea and thiourea derivatives of isoxazolo[4,5-d]pyridazine and structurally related thiazolo[4,5-d]pyridazine as antimicrobial agents

2013 ◽  
Vol 36 (11) ◽  
pp. 1354-1368 ◽  
Author(s):  
Hassan M. Faidallah ◽  
Sherif A. F. Rostom ◽  
Salem A. Basaif ◽  
Mohammed S. T. Makki ◽  
Khalid A. Khan
Keyword(s):  
Antimicrobial Agents ◽  
Biological Evaluation ◽  
Thiourea Derivatives ◽  
Synthesis And Biological Evaluation ◽  
Derivatives Of

scholarly journals Synthesis and biological evaluation of novel urea and thiourea derivatives of valacyclovir

2014 ◽  
Vol 79 (3) ◽  
pp. 283-289 ◽  
Author(s):  
Ramana Katla ◽  
Rasheed Syed ◽  
Madhava Golla ◽  
Adam Shaik ◽  
Raju Chamarthi
Keyword(s):  
Antioxidant Activity ◽  
Antiviral Activity ◽  
Elemental Analysis ◽  
Antioxidant Activities ◽  
Biological Evaluation ◽  
Thiourea Derivatives ◽  
Mass Spectral ◽  
High Yields ◽  
Synthesis And Biological Evaluation ◽  
Derivatives Of

A series of novel urea and thiourea derivatives of valacyclovir were efficiently synthesized in high yields and evaluated their antiviral activity. 2-((6-Amino-4-oxo-4,5-dihydro-1H-imidazo[4,5-c]pyridin-1-yl)methoxy)ethyl-2-amino-3-ethylbutanoate (valacyclovir) 1 is reacted with various aromatic isocyanates/thiocyanates 2 in the presence of N, N- dimethyl piperazine as a base in THF: pyridine (4:1) to obtain valacyclovir urea/thiourea derivatives 3(a-j). The structures of the title compounds 3(a-j) were confirmed by IR, NMR (1H, 13C), mass spectral and elemental analysis. The newly synthesized compounds were screened for their antiviral activity against Tobacco mosaic virus (TMV) and antioxidant activity was evaluated by DPPH, SOD and GST methods. The title compounds exhibited potent antiviral and good antioxidant activities.

Design, synthesis and biological evaluation of novel triazole, urea and thiourea derivatives of quinoline against Mycobacterium tuberculosis

2009 ◽  
Vol 17 (13) ◽  
pp. 4681-4692 ◽  
Author(s):  
Ram Shankar Upadhayaya ◽  
Girish M. Kulkarni ◽  
Nageswara Rao Vasireddy ◽  
Jaya Kishore Vandavasi ◽  
Shailesh S. Dixit ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Thiourea Derivatives ◽  
Synthesis And Biological Evaluation ◽  
Derivatives Of
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