A case of concurrent pancreatic intraepithelial neoplasia and type 1 autoimmune pancreatitis with marked pancreatic duct dilatation

2016 ◽  
Vol 9 (4) ◽  
pp. 266-271 ◽  
Author(s):  
Yuichi Takano ◽  
Masatsugu Nagahama ◽  
Eiichi Yamamura ◽  
Naotaka Maruoka ◽  
Kazuaki Yokomizo ◽  
...  
Keyword(s):  
Pancreatic Duct ◽  
Autoimmune Pancreatitis ◽  
Intraepithelial Neoplasia ◽  
Pancreatic Intraepithelial Neoplasia ◽  
Duct Dilatation ◽  
Type 1 Autoimmune Pancreatitis ◽  
Pancreatic Duct Dilatation

scholarly journals Type 1 autoimmune pancreatitis with main pancreatic duct dilatation and pancreatic cysts: A case report

Suizo ◽  
2015 ◽  
Vol 30 (2) ◽  
pp. 219-226 ◽  
Author(s):  
Yasunari FUKUDA ◽  
Tadafumi ASAOKA ◽  
Atsushi MIYAMOTO ◽  
Kiyoshi MORI ◽  
Yoshinori KODAMA ◽  
...  
Keyword(s):  
Case Report ◽  
Pancreatic Duct ◽  
Autoimmune Pancreatitis ◽  
Main Pancreatic Duct ◽  
Pancreatic Cysts ◽  
Duct Dilatation ◽  
Main Pancreatic Duct Dilatation ◽  
Type 1 Autoimmune Pancreatitis ◽  
Pancreatic Duct Dilatation

A case of high‐grade pancreatic intraepithelial neoplasia concomitant with type 1 autoimmune pancreatitis: The process underlying both conditions

2019 ◽  
Vol 69 (3) ◽  
pp. 165-171
Author(s):  
Tomoko Sugiyama ◽  
Takuma Tajiri ◽  
Shinichiro Hiraiwa ◽  
Tomohisa Machida ◽  
Hiroyuki Ito ◽  
...  
Keyword(s):  
Autoimmune Pancreatitis ◽  
Intraepithelial Neoplasia ◽  
High Grade ◽  
Pancreatic Intraepithelial Neoplasia ◽  
Type 1 Autoimmune Pancreatitis

Histological features of pancreatic duct lesions correlate with the degree of lobular injuries in type 1 autoimmune pancreatitis (AIP)

Pancreatology ◽  
2016 ◽  
Vol 16 (4) ◽  
pp. S56-S57
Author(s):  
Kenji Notohara ◽  
Takahiro Nakazawa ◽  
Tsuyoshi Uehara ◽  
Shigeyuki Kawa
Keyword(s):  
Pancreatic Duct ◽  
Autoimmune Pancreatitis ◽  
Histological Features ◽  
Type 1 Autoimmune Pancreatitis

Intraductal Tubulopapillary Epithelial Proliferation Associated with Type 1 Autoimmune Pancreatitis

2018 ◽  
Vol 27 (1) ◽  
pp. 83-87 ◽  
Author(s):  
Shinya Fujie ◽  
Hiroyuki Matsubayashi ◽  
Hirotoshi Ishiwatari ◽  
Hiromasa Hazama ◽  
Takaaki Ito ◽  
...  
Keyword(s):  
Pancreatic Duct ◽  
Autoimmune Pancreatitis ◽  
Fibrous Tissue ◽  
Ductal Adenocarcinoma ◽  
Epithelial Proliferation ◽  
Pancreatic Body ◽  
Gastric Type ◽  
Serum Igg4 ◽  
Type 1 Autoimmune Pancreatitis

A 70-year-old man was referred to our hospital with exacerbation of diabetes. His blood tests showed elevated levels of serum IgG4 and HbA1c. Computed tomography of the pancreatic body demonstrated a weakly enhanced mass, 2 cm in size, with indistinct borders. Magnetic resonance cholangiopancreatography revealed a narrowing of the main pancreatic duct (MPD) at the pancreatic body, a markedly dilated upstream duct, and a slightly dilated downstream duct. Endoscopic ultrasonography demonstrated an iso-hypoechoic heterogeneous mass, protruding and spreading in the pancreatic duct. The histology of a fine needle aspiration sample demonstrated fibrous tissue containing abundant IgG4-positive plasma cells and atypical epithelial cells. The imaging findings and histology were not typical for either pancreatic ductal adenocarcinoma or type 1 autoimmune pancreatitis (AIP), but these were not completely excluded, and a distal pancreatectomy was performed. Histological examination showed an intraductal tubulopapillary epithelial proliferation, which contained cytoplasmic mucin (MUC5AC and MUC6), and severe IgG4-positive lymphoplasmacytic infiltration in the interstitium around the MPD. Next-generation sequencing using DNA extracted from the tumor revealed no mutation of K-ras, GNAS, or TP53. The entire lesion was ultimately diagnosed as AIP with an intraductal tubular and papillary epithelial hyperplasia producing gastric-type mucin. Some recent reports have described AIP development in the background of intraductal papillary mucinous neoplasms, and some have hypothesized a paraneoplastic occurrence of IgG4-related disease. The current case indicates issues in the clinical diagnosis of rare variants of AIP, and raises questions about the relationship between AIP and pancreatic epithelial lesions.

scholarly journals Type 1 Autoimmune Pancreatitis Extending along the Main Pancreatic Duct: IgG4-related Pancreatic Periductitis

2021 ◽  
Author(s):  
Junya Sato ◽  
Hiroyuki Matsubayashi ◽  
Hirotoshi Ishiwatari ◽  
Tatsunori Satoh ◽  
Junichi Kaneko ◽  
...  
Keyword(s):  
Pancreatic Duct ◽  
Autoimmune Pancreatitis ◽  
Main Pancreatic Duct ◽  
Type 1 Autoimmune Pancreatitis

A case of pancreatic intraepithelial neoplasia detected by pancreatic duct dilation

2021 ◽  
Vol 99 (1) ◽  
pp. 146-148
Author(s):  
Hironori Tanei ◽  
Reina Tanaka ◽  
Takayoshi Tsuchiya ◽  
Kentaro Ishii ◽  
Ryosuke Tonozuka ◽  
...  
Keyword(s):  
Pancreatic Duct ◽  
Intraepithelial Neoplasia ◽  
Pancreatic Intraepithelial Neoplasia

Serum and histological IgG4-negative type 1 autoimmune pancreatitis

2018 ◽  
Vol 12 (3) ◽  
pp. 232-238 ◽  
Author(s):  
Yuichi Takano ◽  
Takahiro Kobayashi ◽  
Fumitaka Niiya ◽  
Eiichi Yamamura ◽  
Naotaka Maruoka ◽  
...  
Keyword(s):  
Autoimmune Pancreatitis ◽  
Negative Type ◽  
Type 1 Autoimmune Pancreatitis

scholarly journals Type 1 autoimmune pancreatitis

2011 ◽  
Vol 6 (1) ◽  
pp. 82 ◽  
Author(s):  
Yoh Zen ◽  
Dimitrios P Bogdanos ◽  
Shigeyuki Kawa
Keyword(s):  
Autoimmune Pancreatitis ◽  
Type 1 Autoimmune Pancreatitis
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