scholarly journals Germ cell tumour compressing the right atrium

2012 ◽  
Vol 22 (2) ◽  
pp. 86-87 ◽  
Author(s):  
Sait Demirkol ◽  
Oben Baysan ◽  
Turgay Celik ◽  
Bulent Karaman ◽  
Seyfettin Gumus
Keyword(s):  
Germ Cell ◽  
Right Atrium ◽  
Germ Cell Tumour ◽  
Cell Tumour ◽  
The Right

scholarly journals Giant adrenal germ cell tumour in a 59-year-old woman

2016 ◽  
Vol 10 (5-6) ◽  
pp. 201
Author(s):  
Lei Chen ◽  
Lu Fang ◽  
Zhiqi Liu ◽  
Dexin Yu ◽  
Daming Wang ◽  
...  
Keyword(s):  
Pleural Effusion ◽  
Lymph Nodes ◽  
Germ Cell ◽  
Germ Cell Tumour ◽  
Malignant Tumour ◽  
Large Mass ◽  
Needle Aspiration ◽  
Cell Tumour ◽  
Supraclavicular Lymph Nodes ◽  
The Right

Adrenal germ cell tumour is very rare. We report a case of a 59-year-old woman who presented with right flank discomfort. The laboratory examinations were normal and the chest computed tomography (CT) showed right pleural effusion. The abdominal CT scan revealed a large mass on the right adrenal gland. The patient underwent an adrenalectomy. Histopathologic examination and immunohistochemical findings were consistent with mixed germ cell tumour. Three months later following the operation, the patient was admitted to our hospital again with chest tightness and shortness of breath. The chest CT showed right pleural effusion recurrence and enlargement of mediastinal lymph nodes and right hilar lymph nodes. The patient had right supraclavicular lymphadenectasis on physical examination. Fine needle aspiration cytology from the supraclavicular lymph nodes showed groups of malignant tumour cells. The patient died within 6 months postoperatively. In this case, the lymph node pathway played an important role in the metastatic procedure.

A suprasellar germ cell tumour presenting with cranial diabetes insipidus

2019 ◽  
Author(s):  
Suhaniya Samarasinghe ◽  
Rebecca Scott ◽  
Michael J Seckl ◽  
Mike Gonzalez ◽  
Richard Harvey ◽  
...  
Keyword(s):  
Germ Cell ◽  
Diabetes Insipidus ◽  
Germ Cell Tumour ◽  
Cell Tumour ◽  
Cranial Diabetes Insipidus

scholarly journals Cardiac metastasis of a rapid-moving mixed germ cell tumour visualized by transoesophageal echocardiography

2021 ◽  
Vol 5 (2) ◽  
Author(s):  
Toshimitsu Kato ◽  
Noriaki Takama ◽  
Tomonari Harada ◽  
Tomonobu Abe
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumour ◽  
Transoesophageal Echocardiography ◽  
Cell Tumour ◽  
Cardiac Metastasis

scholarly journals COVD-01. VINBLASTINE MONOTHERAPY INDUCTION FOR LOCALISED CNS GERMINOMA DURING THE COVID-19 PANDEMIC

2020 ◽  
Vol 22 (Supplement_3) ◽  
pp. iii282-iii282
Author(s):  
Rafael Moleron ◽  
Sara Stoneham ◽  
Thankamma Ajithkumar ◽  
Justin Cross ◽  
James Nicholson ◽  
...  
Keyword(s):  
Germ Cell ◽  
Treatment Options ◽  
Single Agent ◽  
Germ Cell Tumour ◽  
Research Priorities ◽  
Tumour Volume ◽  
Cell Tumour ◽  
Low Grade ◽  
Testicular Seminoma

Abstract INTRODUCTION Patients with localised CNS-germinoma have excellent survival. More recently, intensive inpatient chemotherapy (carboPEI=carboplatin/etoposide/ifosfamide in Europe) has been effectively employed to reduce radiotherapy fields and/or dose. Current research priorities focus on reducing treatment burden and long-term sequelae. Of note, outpatient-based single-agent carboplatin chemotherapy is associated with excellent outcomes in metastatic testicular seminoma (an identical pathology) [Alifrangis,EJC,2020]. Recently, successful vinblastine monotherapy was reported in localised CNS-germinoma [Murray,Neurooncol-Adv,2020]. METHODS Due to the COVID-19 pandemic, adapted UK guidelines for germ-cell-tumour management were distributed, including potential non-standard treatment options that would reduce hospital visits/admissions. A 30-year-old patient presented with a 32mmx30mmx35mm diameter solid+multi-cystic localised pineal CNS lesion, consistent radiologically with a germ-cell-tumour with prominent teratoma component. Investigation revealed negative AFP/HCG markers and biopsy-proven pure germinoma. After appropriate consent, the patient commenced 12-week induction with weekly vinblastine monotherapy (low-grade-glioma dosing [Lassaletta,JCO,2016]), with wk6&12 MRI re-assessment prior to definitive radiotherapy. RESULTS Vinblastine was well-tolerated. After initial 4mg/m2 test-dosing (wk1), standard 6mg/m2 was delivered for wk2, but resulted in asymptomatic neutropenia (nadir 0.3x10^9/l) and missed dosing at wk3. Subsequent doses were 4mg/m2, with no further neutropenia. As expected, MRI showed moderate 40% tumour volume reduction by wk12. Surgical resection of the residual presumed teratoma component was undertaken prior to radiotherapy. CONCLUSION Patients with CNS-germinoma have excellent outcomes and reduction of treatment-effects remains a priority. The exquisite chemosensitivity of germinoma, excellent results from monotherapy for metastatic testicular disease, and early promise of vinblastine monotherapy lend itself to further exploration for CNS-germinoma.

scholarly journals Germ cell tumour chemotherapy

1989 ◽  
Vol 59 (2) ◽  
pp. 156-159 ◽  
Author(s):  
A Horwich
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumour ◽  
Cell Tumour

Testicular germ cell tumour presenting as thyrotoxicosis

2004 ◽  
Vol 41 (6) ◽  
pp. 503-504
Author(s):  
A Elfatih ◽  
M. Griffiths ◽  
R Gama
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumour ◽  
Cell Tumour ◽  
Testicular Germ Cell Tumour ◽  
Testicular Germ Cell

Paraganglion cells stain positively for OCT4: a potential pitfall in assessing retroperitoneal lymph node dissection specimens for germ cell tumour metastasis

2012 ◽  
Vol 62 (2) ◽  
pp. 360-363 ◽  
Author(s):  
Jessica A Clevenger ◽  
Jennifer B Kum ◽  
Riley E Alexander ◽  
David J Grignon ◽  
Liang Cheng ◽  
...  
Keyword(s):  
Lymph Node ◽  
Germ Cell ◽  
Lymph Node Dissection ◽  
Germ Cell Tumour ◽  
Cell Tumour ◽  
Retroperitoneal Lymph Node Dissection ◽  
Node Dissection ◽  
Retroperitoneal Lymph Node ◽  
Potential Pitfall ◽  
Tumour Metastasis

102 Germ cell tumour trials: recent advantages and future directions

2009 ◽  
Vol 7 (2) ◽  
pp. 27
Author(s):  
G. Calaminus
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumour ◽  
Cell Tumour ◽  
Future Directions

Intracranial germ cell tumour

2021 ◽  
Author(s):  
Jonathan Dillon
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumour ◽  
Cell Tumour ◽  
Intracranial Germ Cell Tumour
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