Effect of gluten free diet on gastrointestinal and behavioral indices for children with autism spectrum disorders: a randomized clinical trial

2016 ◽  
Vol 12 (4) ◽  
pp. 436-442 ◽  
Author(s):  
Faezeh Ghalichi ◽  
Jamal Ghaemmaghami ◽  
Ayyoub Malek ◽  
Alireza Ostadrahimi
Author(s):  
I. A. Bavykina

Introduction. Autism spectrum disorders are a widespread pathology, but the etiological factors of their occurrence have not yet been established. The aim of the study was to compare the levels of I-FABP in children with autism spectrum disorders, depending on the adherence to a gluten-free diet. Materials and methods. The study included 36 patients with autism committed to a gluten-free diet for more than six months and 49 patients with autism spectrum disorders who did not have dietary restrictions. There are no statistically significant age differences between the groups. The patients were evaluated and compared with the level of intestinal protein binding fatty acids. Results. Children using diet therapy were found to have significantly lower intestinal permeability. In particular, the average level of I-FABP in children with autism spectrum disorders followed a gluten-free diet is 156.20 ± 102.16 pg/ml, with non-compliance with diet therapy. The average value of the index is diagnosed at the level of 528.26 ± 255.95 pg/ml because the protein binding fatty acids are a marker of small intestine permeability. Children with autism spectrum disorders without adherence to a gluten-free diet show intestinal permeability higher than that of their peers with autism, who long exclude gluten from the diet. Conclusions. Further research is needed to assess the significance of the intestinal fatty acid-binding protein in the etiology and clinical presentation of various diseases, particularly in autism spectrum disorders. Before using diet therapy, all patients with autism need to consult a gastroenterologist to objectively assess the need for its compliance and dynamic monitoring of its effectiveness in case of use.


2020 ◽  
pp. 321-328

Background. Gluten-free and casein-free diet is frequently used in the support of therapy of children with autism spectrum disorders. In addition, many parents restrict the consumption of simple sugars for their children. Objective. The aim of this paper was to understand factors influencing purchase decision in case of family with children with autism spectrum disorders on gluten-free and/or casein-free and/or sugar-free diet and the difficulties associated with this type of nutrition. Material and methods. The study covered a group of 40 families with children with autism spectrum disorders (32 boys and 8 girls) aged 3 to 10 years. Data were collected with questionnaire included questions concerning overall characteristics of caregivers, availability of foods used in the special diet, factors affecting decision on the purchase of products, difficulties in maintaining the child nutrition method. Results. The factors having strongest impact on parents’ decisions on the purchase of products were product composition, presence of a certificate confirming the absence of gluten and/or milk and taste values. Exclusion diet constituted a considerable obstruction for traveling, social gatherings and resulted in conflicts with family and the environment. The limited range of healthy gluten-free, casein-free and sugar-free foods, low taste quality and unsatisfactory quality impeded purchase and preparation of varied meals. Conclusions. The surveyed parents were aware consumers, paying attention primarily to product composition and safety. The respondents were looking for healthy, organic and nutritionally valuable products with low sugar content. Further development of the gluten/casein/ sugar free products market may considerably improve certain aspects of family’s life with children with autism spectrum disorders.


2012 ◽  
Vol 49 (10) ◽  
pp. 942-954 ◽  
Author(s):  
Marcus L. Thomeer ◽  
Christopher Lopata ◽  
Martin A. Volker ◽  
Jennifer A. Toomey ◽  
Gloria K. Lee ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document