Upregulation of Striatal Metabotropic Glutamate Receptor Subtype 1 (mGluR1) in Rats with Excessive Glutamate Release Induced by N-Acetylcysteine

2022 ◽  
Author(s):  
Tomoteru Yamasaki ◽  
Maki Okada ◽  
Atsuto Hiraishi ◽  
Wakana Mori ◽  
Yiding Zhang ◽  
...  
Keyword(s):  
Glutamate Receptor ◽  
Metabotropic Glutamate Receptor ◽  
Glutamate Release ◽  
Receptor Subtype ◽  
Metabotropic Glutamate

scholarly journals Acute Ketamine Infusion in Rat Does Not Affect In Vivo [11C]ABP688 Binding to Metabotropic Glutamate Receptor Subtype 5

2018 ◽  
Vol 17 ◽  
pp. 153601211878863 ◽  
Author(s):  
Lauren Kosten ◽  
Jeroen Verhaeghe ◽  
Leonie wyffels ◽  
Sigrid Stroobants ◽  
Steven Staelens
Keyword(s):  
Nmda Receptor ◽  
Glutamate Receptor ◽  
Metabotropic Glutamate Receptor ◽  
Glutamate Release ◽  
Acute Effect ◽  
Receptor Subtype ◽  
Ketamine Infusion ◽  
Metabotropic Glutamate ◽  
Pet Tracer

Detecting changes in metabotropic glutamate receptor 5 (mGluR5) availability through molecular imaging with the positron emission tomography (PET) tracer [11C]ABP688 is valuable for studying dysfunctional glutamate transmission associated with neuropsychiatric disorders. Using an infusion protocol in rats, we visualized the acute effect of subanesthetic doses of ketamine on mGluR5 in rat brain. Ketamine is an N-methyl-D-aspartate (NMDA) receptor antagonist known to increase glutamate release. Imaging was performed with a high-affinity PET ligand [11C]ABP688, a negative allosteric modulator of mGluR5. Binding did not change significantly from baseline to ketamine in any region, thereby confirming previous literature with other NMDA receptor antagonists in rodents. Hence, in rats, we could not reproduce the findings in a human setup showing significant decreases in the [11C]ABP688 binding after a ketamine bolus followed by ketamine infusion. Species differences may have contributed to the different findings in the present study of rats. In conclusion, we could not confirm in rats that endogenous glutamate increases by ketamine infusion are reflected in [11C]ABP688 binding decreases as was previously shown for humans.

Alcohol Addiction- Metabotropic Glutamate Receptor Subtype 5 and its Ligands: How They All Come Together?

2018 ◽  
Vol 19 (8) ◽  
pp. 907-915 ◽  
Author(s):  
Jaya Kumar ◽  
Zalina Ismail ◽  
Nurul Hazwani Hatta ◽  
Najwa Baharuddin ◽  
Hermizi Hapidin ◽  
...  
Keyword(s):  
Glutamate Receptor ◽  
Metabotropic Glutamate Receptor ◽  
Alcohol Addiction ◽  
Receptor Subtype ◽  
Metabotropic Glutamate
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