Comparison of 99mTc Pertechnetate Thyroid Uptake Rates by Gamma Probe and Gamma Camera Methods for Differentiating Graves’ Disease and Thyroiditis

2022 ◽  
Author(s):  
Meihua Jin ◽  
Jonghwa Ahn ◽  
Seong-gil Jo ◽  
Jangwon Park ◽  
Min Ji Jeon ◽  
...  
Keyword(s):  
Gamma Camera ◽  
Gamma Probe ◽  
Graves Disease ◽  
99Mtc Pertechnetate ◽  
Uptake Rates ◽  
Thyroid Uptake

Comparison of Tc-99m Pertechnetate Thyroid Uptake Rates by Gamma Probe and Gamma Camera Methods for Differentiating Graves’ Disease and Thyroiditis

2021 ◽  
Author(s):  
Meihua Jin ◽  
Jonghwa Ahn ◽  
Seong-gil Jo ◽  
Jangwon Park ◽  
Min Ji Jeon ◽  
...  
Keyword(s):  
Diagnostic Accuracy ◽  
Uptake Rate ◽  
Gamma Camera ◽  
Gamma Probe ◽  
Probe Method ◽  
Graves Disease ◽  
Reference Ranges ◽  
Cutoff Value ◽  
Uptake Rates ◽  
Thyroid Uptake

Abstract Although technetium-99m (99mTc) pertechnetate thyroid uptake rate can be measured by gamma camera with scintigraphy as well as by gamma probe, the normal reference range known as quite different between them. This study was performed to compare their diagnostic accuracy for evaluating patients with hyperthyroidism. We retrospectively reviewed consecutive 371 patients (euthyroid 89, Graves 167, and thyroiditis 115) who had simultaneously measured data of thyroid uptake rates by both gamma probe and camera methods in our hospital from November 2019 to June 2020. The reference ranges in euthyroid patients were 2.0-4.7% and 0.3–1.9% for probe and camera methods, respectively. For differentiating Graves’ disease and thyroiditis, the area under the curve of the camera method was significantly greater than that of the probe method (0.988 vs 0.975, p = 0.030) on receiver operating characteristic curve analysis. With a cutoff value of 0.7%, the sensitivity and specificity for the camera method were 93.4% and 94.8%, respectively. With a cutoff value of 3.0%, those for the probe method were 92.2% and 91.3%, respectively. In conclusion, 99mTc pertechnetate thyroid uptake rate measured by the camera method with scintigraphy had higher diagnostic accuracy than the probe method for evaluating patients with hyperthyroidism.

Diagnostic Value of 20 Minute 99mTc Pertechnetate Thyroid Uptake

1971 ◽  
Vol 10 (04) ◽  
pp. 305-315
Author(s):  
T. M. D. Gimlette ◽  
R. Höschl
Keyword(s):  
Gamma Camera ◽  
Processing System ◽  
Nuclear Data ◽  
Close Correlation ◽  
Diagnostic Value ◽  
Computer Assisted ◽  
Computer Technique ◽  
99Mtc Pertechnetate ◽  
Thyroid Uptake ◽  
Stimulation Tests

SummaryFour hour thyroid uptake of orally administered radioiodine was compared with 20 minute uptake of intravenously given 99mTc pertechnetate in 170 patients.Pertechnetate uptake was estimated by counting dots on a rectilinear scan, with appropriate background subtraction. In 22 patients the dot counting method was compared with computer assisted processing of a gamma camera image, using Nuclear Data 50/50 MED Digital Image Processing System. There was good correlation between the two methods, the computer technique is faster and easier, but does not provide, at the same time, a very satisfactory thyroid scan.Optimum interval for measurement of pertechnetate thyroid uptake with the rectilinear scanner is 20—30 minutes after the intravenous dose. When the computer assisted gamma camera can be employed the 10 minute interval would probably be more suitable for differentiation between euthyroid and hyperthyroid patients.For diagnostic accuracy the radioiodine and pertechnetate methods were identical (87% correct), there was quite close correlation between them and both were suitable for T3 suppression and TSH stimulation tests. The pertechnetate method is quicker to complete and provides a scan of the thyroid, but it requires an intravenous injection and is more demanding in personnel and equipment.

High pre-therapy [99mTc]pertechnetate thyroid uptake, thyroid size and thyrostatic drugs: predictive factors of failure in [131I]iodide therapy in Graves?? disease

2005 ◽  
Vol 26 (11) ◽  
pp. 957-963 ◽  
Author(s):  
Denise E. Zantut-Wittmann ◽  
Celso D. Ramos ◽  
Allan O. Santos ◽  
Marcelo M.O. Lima ◽  
Anita D. Panzan ◽  
...  
Keyword(s):  
Predictive Factors ◽  
Graves Disease ◽  
99Mtc Pertechnetate ◽  
Thyroid Uptake

Thyroid Uptake of Technegas during V/Q Scintigraphy in Graves Disease

2010 ◽  
Vol 123 (5) ◽  
pp. e3-e4
Author(s):  
Andrew E.H. Tan ◽  
Uei Pua
Keyword(s):  
Graves Disease ◽  
Thyroid Uptake

Predictive value of pyramidal lobe, percentage thyroid uptake and age for ablation outcome after 15 mCi fixed dose of radioiodine-131 in Graves′ disease

2015 ◽  
Vol 0 (0) ◽  
pp. 0
Author(s):  
Maseeh uz Zaman ◽  
Nosheen Fatima ◽  
Unaiza Zaman ◽  
Zafar Sajjad ◽  
Rabia Tahseen ◽  
...  
Keyword(s):  
Predictive Value ◽  
Fixed Dose ◽  
Graves Disease ◽  
Thyroid Uptake ◽  
Pyramidal Lobe

An Interactive Freehand ROI Tool for Thyroid Uptake Studies Using Gamma Camera

2016 ◽  
pp. 349-355
Author(s):  
Palla Sri Harsha ◽  
A. Shiva ◽  
Kumar T. Rajamani ◽  
Siva Subramanyam ◽  
Siva Sankar Sai
Keyword(s):  
Gamma Camera ◽  
Thyroid Uptake ◽  
Uptake Studies

Factitious thyrotoxicosis: how to find it

Diagnosis ◽  
2020 ◽  
Vol 7 (2) ◽  
pp. 141-145
Author(s):  
Pakaworn Vorasart ◽  
Chutintorn Sriphrapradang
Keyword(s):  
Radioactive Iodine ◽  
Graves Disease ◽  
Case Presentation ◽  
Thyroglobulin Antibodies ◽  
Definitive Therapy ◽  
Thyroid Uptake ◽  
Thyroid Hormone Levels ◽  
Difficult Challenge

AbstractBackgroundAlthough the most common cause of thyrotoxicosis is Graves’ disease, the determination of the cause of thyrotoxicosis is important for establishing appropriate management. Diagnosis of surreptitious ingestion of thyroid hormones or factitious thyrotoxicosis often presents a difficult challenge especially in a patient with previously diagnosed Graves’ disease. The objective of this report was to demonstrate various approaches to support the diagnosis of factitious thyrotoxicosis.Case presentationWe describe a patient with underlying Graves’ disease who underwent definitive therapy and needed long-term levothyroxine (LT4) replacement therapy. Later she developed thyrotoxicosis. Although factitious thyrotoxicosis was suspected because of very low thyroid uptake and low thyroglobulin (Tg) levels with the absence of thyroglobulin antibodies (TgAbs), she still refused any medication or substance use. After the administration of bile acid sequestrant, the thyroid hormone levels rapidly returned to normal within 1 month.ConclusionsThe diagnosis of factitious thyrotoxicosis is based upon the absence of goiter, suppressed serum Tg level, decreased radioactive iodine (RAI) uptake, and excellent response after cholestyramine treatment.

Somatostatin Receptor Expression in the Thyroid Demonstrated with 111In-Octreotide Scintigraphy

1995 ◽  
Vol 34 (03) ◽  
pp. 100-103 ◽  
Author(s):  
U. Schrell ◽  
M. Buchfelder ◽  
J. Hensen ◽  
J. Wendler ◽  
M. Gramatzki ◽  
...  
Keyword(s):  
Thyroid Gland ◽  
Thyroid Disease ◽  
Endemic Goiter ◽  
Somatostatin Receptor ◽  
Receptor Expression ◽  
Graves Disease ◽  
Tumor Localization ◽  
Thyroid Autonomy ◽  
Thyroid Uptake ◽  
Octreotide Scintigraphy

SummaryNeuroendocrine tumors with somatostatin receptor expression may be localized by 111ln-octreotide scintigraphy. This study examines those thyroid conditions where 111 ln-octreotide uptake could be observed also in the thyroid gland. 26 consecutive patients who underwent 111 ln-octreotide scintigraphy for tumor localization were additionally examined for thyroid disease by sonography and 99mTc-pertechnetate scintigraphy. 12 of these patients had no significant thyroid uptake and had an euthyroid normal-sized thyroid gland. 14 patiens with 111ln thyroid uptakes had endemic goiters, two of them with thyroid autonomy and one with Graves’ disease. Thus, 111 ln-octreotide thyroid uptake was predominantly seen in patients with endemic goiter with or without thyroid autonomy.

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