On the characteristics of endemic goiter in the Gorky region

At the 22nd All-Union Congress of Surgeons, V.S. Levit, in his keynote speech, highlighting the distribution of endemic goiter in the Soviet Union, noted that goiter occurs in the Nizhny Novgorod Territory in the region of Murom and Kovrov. Before the Great October Revolution, the issues of endemic goiter in the Nizhny Novgorod province were not studied

Some questions of the clinic of endemic goiter in the Leninogorsk region of the Tatar ASSR

The clinic and the course of endemic goiter have features in various foci of endemic (A. T. Lidsky, O. V. Nikolaev, I. I. Rusetsky, I. B. Khavin, etc.).

Frequency of endemic goiter and indicators of pituitary-thyroid profile in Arctic children

Objective. Analysis of the frequency of endemic goiter and indicators of the pituitary-thyroid profile in children aged 10-18 years living in the Arctic regions of Yakutia. Materials and methods. The study was conducted among children and adolescents of the Arctic regions of Yakutia (Bulunsky, Anabarsky, Allaikhovsky, Nizhnekolymsky, Verkhnekolymsky district) during field medical expeditions in 20182020. A total of 392 children aged 1018 years were examined. Results. In 30 % of the examined children, an increase in the thyroid gland was observed, which was accompanied by elevated levels of free thyroxine. In 3 % of children, an increase in the level of thyroid-stimulating hormone was detected against the background of reduced or normal levels of free thyroxine. Conclusions. As for the prevalence of cases of endemic goiter, the Arctic regions of Yakutia are the areas of severe goiter endemia. The results obtained justify the need for additional scientific studies to assess the degree of iodine availability (by the concentration of iodine in the urine) in different population groups and real implementation of the strategy of mass preventive measures.

Not that simple goiter

The year 2020 marks the centenary of the publication of a classic study by American physicians D. Marine and O. Kimball on the effectiveness of endemic goiter prevention in children in Akron, Ohio. Although goiter has been known from immemorial times, there is still a problem with determining the normal size of the thyroid gland, without which the diagnosis of goiter remains extremely subjective. For example, in Sweden over the past 20 years, not a single case of endemic goiter has been registered, which is not surprising: the country eliminated this pathology decades ago, and the median urinary iodine concentration indicates the optimal iodine intake. Cases of sporadic goiter in children in Sweden are also rare — no more than 6–8 per year. But in Belarus, with the same population (about 10 million), about 2900 cases of goiter in children, both endemic and sporadic, are recorded annually despite the fact that, due to the extensive use of iodized salt since the beginning of the 2000s, there is no iodine deficiency. The incidence of goiter in children, however, having decreased many times over the past 20 years, remains 3 times higher than in Russia, where iodine prophylaxis, if carried out on a limited scale. From the experience of Belarus, Sweden and Russia, we see that the main thing when assessing data on the incidence of goiter and other thyroid diseases associated with iodine deficiency should be not absolute numbers, but the trend of these indicators over the past years. This information should be more actively used by endocrinologists in Russia to assess the effectiveness of preventive measures both at the regional and federal levels.

The development of a rye-wheat bread recipe using apple iodine pectin extract

Currently, a promising direction in baking is the introduction of microelements such as iodine into the recipe of bread and bakery products. The presence of iodine in the formation of the thyroid hormone determines its biological role. This trace element is the only one known that is involved in the construction of hormones. The development of endemic goiter is caused by a lack of iodine in the body. The influence of apple iodine-pectin extract on physical and chemical quality indicators (moisture, acidity and porosity) of rye-wheat bread was studied. During the manufacturing process of a prototype rye-wheat bread, a standard recipe was used with the replacement of part of the water with apple iodine pectin extract obtained using sodium bicarbonate and adding iodine. The addition of this additive to the rye-wheat bread recipe improves organoleptic quality indicators. In terms of physical and chemical characteristics, bread with the addition of apple iodine-pectin extract meets the requirements of regulatory documents and standards. In order to justify the introduction of apple iodine-pectin extract into the rye-wheat bread recipe, the content of phosphorus and iron in bread samples was analysed using a spectrophotometer. A sample bread containing iodcasein from a local manufacturer was used as a benchmark for the purpose of this review. The iodine content was determined by titration of iodine released during the interaction of potassium iodate and potassium iodide. Analysis of the chemical composition showed that the introduction of apple iodine-pectin extract into the formulation contributes to an increase in the content of minerals, macro- and microelements in bread. On comparison of the samples, the test sample containing apple iodine pectin extract proved to stay fresh for longer than a control sample for 12-24 hours.