Feasibility of a novel photoproduction of 225Ac and 227Th with natural thorium target

We propose an innovative way to produce both 225Ac and 227Th, two precious radioisotopes enabling promising targeted alpha therapy, in a natural thorium target bombarded with a 30–90 MeV electron beam. Bremsstrahlung photons in the target are analyzed by MCNP and in-situ photonuclear transmutation of 232Th is evaluated by using the TENDL nuclear data. In the photo-transmutation analysis, 13 nuclides including 229Th and 231Pa are modelled. Special procedures with chemical separations are also proposed to produce pure 225Ac and 227Th in separate streams. In addition, performance of the new approach is compared with conventional methods in terms of the 225Ac and 227Th yields. After a Th target is bombarded with a 500 kW electron beam for a year, yearly 225Ac yield is ~ 8.47 GBq (semi-permanently) and yearly 227Th yield is ~ 48.9 GBq over 50 years, and their yields are at least doubled in a 2-year irradiation. This work will help increase global supply of the two precious isotopes and would invariably help advance TAT-related researches and developments.

Overview of JET results for optimising ITER operation

The JET 2019-2020 scientific and technological programme exploited the results of years of concerted scientific and engineering work, including the ITER-like wall (ILW: Be wall and W divertor) installed in 2010, improved diagnostic capabilities now fully available, a major Neutral Beam Injection (NBI) upgrade providing record power in 2019-2020, and tested the technical & procedural preparation for safe operation with tritium. Research along three complementary axes yielded a wealth of new results. Firstly, the JET plasma programme delivered scenarios suitable for high fusion power and alpha particle physics in the coming D-T campaign (DTE2), with record sustained neutron rates, as well as plasmas for clarifying the impact of isotope mass on plasma core, edge and plasma-wall interactions, and for ITER pre-fusion power operation. The efficacy of the newly installed Shattered Pellet Injector for mitigating disruption forces and runaway electrons was demonstrated. Secondly, research on the consequences of long-term exposure to JET-ILW plasma was completed, with emphasis on wall damage and fuel retention, and with analyses of wall materials and dust particles that will help validate assumptions and codes for design & operation of ITER and DEMO. Thirdly, the nuclear technology programme aiming to deliver maximum technological return from operations in D, T and D-T benefited from the highest D-D neutron yield in years, securing results for validating radiation transport and activation codes, and nuclear data for ITER.

Systematic Distortion Factor and Unrecognized Source of Uncertainties in Nuclear Data Measurements and Evaluations

Each experiment provides new information about the value of some physical quantity. However, not only measured values but also the uncertainties assigned to them are an important part of the results. The metrological guides provide recommendations for the presentation of the uncertainties of the measurement results: statistics and systematic components of the uncertainties should be explained, estimated, and presented separately as the results of the measurements. The experimental set-ups, the models of experiments for the derivation of physical values from primary measured quantities, are the product of human activity, making it a rather subjective field. The Systematic Distortion Factor (SDF) may exist in any experiment. It leads to the bias of the measured value from an unknown “true” value. The SDF appears as a real physical effect if it is not removed with additional measurements or analysis. For a set of measured data with the best evaluated true value, their differences beyond their uncertainties can be explained by the presence of Unrecognized Source of Uncertainties (USU) in these data. We can link the presence of USU in the data with the presence of SDF in the results of measurements. The paper demonstrates the existence of SDF in Prompt Fission Neutron Spectra (PFNS) measurements, measurements of fission cross sections, and measurements of Maxwellian spectrum averaged neutron capture cross sections for astrophysical applications. The paper discusses introducing and accounting for the USU in the data evaluation in cases when SDF cannot be eliminated. As an example, the model case of 238U(n,f)/235U(n,f) cross section ratio evaluation is demonstrated.

Insights from a comprehensive study of Trypanosoma cruzi: A new mitochondrial clade restricted to North and Central America and genetic structure of TcI in the region

More than 100 years since the first description of Chagas Disease and with over 29,000 new cases annually due to vector transmission (in 2010), American Trypanosomiasis remains a Neglected Tropical Disease (NTD). This study presents the most comprehensive Trypanosoma cruzi sampling in terms of geographic locations and triatomine species analyzed to date and includes both nuclear and mitochondrial genomes. This addresses the gap of information from North and Central America. We incorporate new and previously published DNA sequence data from two mitochondrial genes, Cytochrome oxidase II (COII) and NADH dehydrogenase subunit 1 (ND1). These T. cruzi samples were collected over a broad geographic range including 111 parasite DNA samples extracted from triatomines newly collected across NA and CA, all of which were infected with T. cruzi in their natural environment. In addition, we present parasite reduced representation (Restriction site Associated DNA markers, RAD-tag) genomic nuclear data combined with the mitochondrial gene sequences for a subset of the triatomines (27 specimens) collected from Guatemala and El Salvador. Our mitochondrial phylogenetic reconstruction revealed two of the major mitochondrial lineages circulating across North and Central America, as well as the first ever mitochondrial data for TcBat from a triatomine collected in Central America. Our data also show that within mtTcIII, North and Central America represent an independent, distinct clade from South America, named here as mtTcIIINA-CA, geographically restricted to North and Central America. Lastly, the most frequent lineage detected across North and Central America, mtTcI, was also an independent, distinct clade from South America, noted as mtTcINA-CA. Furthermore, nuclear genome data based on Single Nucleotide Polymorphism (SNP) showed genetic structure of lineage TcI from specimens collected in Guatemala and El Salvador supporting the hypothesis that genetic diversity at a local scale has a geographical component. Our multiscale analysis contributes to the understanding of the independent and distinct evolution of T. cruzi lineages in North and Central America regions.

Activities in Divertor Reflector and Linear Plates Using WCLL and HCPB Breeding Blanket Concepts

In fusion devices, such as European Demonstration Fusion Power Reactor (EU DEMO), primary neutrons can cause material activation due to the interaction between the source particles and the targeting material. Subsequently, the reactor’s inner components become activated. For safety and safe performance purposes, it is necessary to evaluate neutron-induced activities. Activities results from divertor reflector and liner plates are presented in this work. The purpose of liner shielding plates is to protect the vacuum vessel and magnet coils from neutrons. As for reflector plates, the function is to shield the cooling components under plasma-facing components from alpha particles, thermal effects, and impurities. Plates are made of Eurofer with a 3 mm layer of tungsten, while the water is used for cooling purposes. The calculations were performed using two EU DEMO MCNP (Monte Carlo N-Particles) models with different breeding blanket configurations: helium-cooled pebble bed (HCPB) and water-cooled lithium lead (WCLL). The TENDL–2017 nuclear data library has been used for activation reactions cross-sections and nuclear reactions. Activation calculations were performed using the FISPACT-II code at the end of irradiation for cooling times of 0 s–1000 years. Radionuclide analysis of divertor liner and reflector plates is also presented in this paper. The main radionuclides, with at least 1% contribution to the total value of activation characteristics, were identified for the previously mentioned cooling times.

Treatments of Thermal Neutron Scattering Data and Their Effect on Neutronics Calculations

In the conventional method to generate thermal scattering cross section of moderator materials, only one of the coherent elastic scattering and incoherent elastic scattering is considered in neutronics calculations. For the inelastic scattering, fixed incident energy grid is used in the nuclear data processing codes. The multipoint linearization method is used to refine the incident energy grid for inelastic scattering. We select ZrHx (zirconium hydride) as an example to analyze the effects of the above described treatments on the reactivity of several critical benchmarks. The numerical results show that the incident energy grid has an obvious effect on the effective multiplication factor (keff) of the analyzed reactors; simultaneously considering the coherent and incoherent elastic scattering also affects keff by tens of pcm.

Complete Mitogenomes of Two Aragoa Species and Phylogeny of Plantagineae (Plantaginaceae, Lamiales) Using Mitochondrial Genes and the Nuclear Ribosomal RNA Repeat

Aragoa, comprising 19 high-altitude North Andean species, is one of three genera in the Plantagineae (Plantaginaceae, Lamiales), along with Littorella and Plantago. Based primarily on plastid data and nuclear ITS, Aragoa is sister to a clade of Littorella + Plantago, but Plantagineae relationships have yet to be assessed using multigene datasets from the nuclear and mitochondrial genomes. Here, complete mitogenomes were assembled for two species of Aragoa (A. abietina and A. cleefii). The mitogenomes of both species have a typical suite of genes for 34 proteins, 17 tRNAs, and three rRNAs. The A. abietina mitogenome assembled into a simple circular map, with no large repeats capable of producing alternative isoforms. The A. cleefii mitogenomic map was more complex, involving two circular maps bridged by a substoichiometric linear fragment. Phylogenetics of three mitochondrial genes or the nuclear rRNA repeat placed Aragoa as sister to Littorella + Plantago, consistent with previous studies. However, P. nubicola, the sole representative of subg. Bougueria, was nested within subg. Psyllium based on the mitochondrial and nuclear data, conflicting with plastid-based analyses. Phylogenetics of the nuclear rRNA repeat provided better resolution overall, whereas relationships from mitochondrial data were hindered by extensive substitution rate variation among lineages.