Efficacy of oral administration of sodium thiosulfate in a large, swine model of oral cyanide toxicity

2021 ◽  
Author(s):  
Patrick C. Ng ◽  
Tara B. Hendry-Hofer ◽  
Matthew Brenner ◽  
Sari B. Mahon ◽  
Gerry R. Boss ◽  
...  
Keyword(s):  
Oral Administration ◽  
Sodium Thiosulfate ◽  
Swine Model ◽  
Cyanide Toxicity

Efficacy of Oral Administration of Sodium Thiosulfate and Glycine in a Large, Swine Model of Oral Cyanide Toxicity

2019 ◽  
Vol 74 (3) ◽  
pp. 423-429 ◽  
Author(s):  
Patrick C. Ng ◽  
Tara B. Hendry-Hofer ◽  
Alyssa E. Witeof ◽  
Sari B. Mahon ◽  
Matthew Brenner ◽  
...  
Keyword(s):  
Oral Administration ◽  
Sodium Thiosulfate ◽  
Swine Model ◽  
Cyanide Toxicity

432 Intravenous Hydroxocobalamin versus Intraosseous Hydroxocobalamin in the Treatment of Acute, Severe Cyanide Toxicity in a Validated Swine Model

2011 ◽  
Vol 58 (4) ◽  
pp. S324
Author(s):  
V.S. Bebarta ◽  
J. Lairet ◽  
R. Pitotti ◽  
P. Dixon ◽  
S. Valtier ◽  
...  
Keyword(s):  
Swine Model ◽  
Cyanide Toxicity

scholarly journals Acute Electrocardiographic ST Segment Elevation May Predict Hypotension in a Swine Model of Severe Cyanide Toxicity

2012 ◽  
Vol 8 (3) ◽  
pp. 285-290 ◽  
Author(s):  
Tylan A. Muncy ◽  
Vikhyat S. Bebarta ◽  
Shawn M. Varney ◽  
Rebecca Pitotti ◽  
Susan Boudreau
Keyword(s):  
Swine Model ◽  
St Segment Elevation ◽  
Cyanide Toxicity ◽  
St Segment

scholarly journals Intraosseous Versus Intravenous Infusion of Hydroxocobalamin for the Treatment Of Acute Severe Cyanide Toxicity in a Swine Model

2014 ◽  
Vol 21 (11) ◽  
pp. 1203-1211 ◽  
Author(s):  
Vikhyat S. Bebarta ◽  
Rebecca L. Pitotti ◽  
Susan Boudreau ◽  
David A. Tanen
Keyword(s):  
Intravenous Infusion ◽  
Swine Model ◽  
Cyanide Toxicity

scholarly journals Sodium Thiosulfate Improves Hypertension in Rats with Adenine-Induced Chronic Kidney Disease

Antioxidants ◽  
2022 ◽  
Vol 11 (1) ◽  
pp. 147
Author(s):  
Chien-Ning Hsu ◽  
Chih-Yao Hou ◽  
Guo-Ping Chang-Chien ◽  
Sufan Lin ◽  
Hung-Wei Yang ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Oral Administration ◽  
Sodium Thiosulfate ◽  
Renin Angiotensin System ◽  
Protective Effects ◽  
Sprague Dawley ◽  
Angiotensin System ◽  
Targeting Therapy ◽  
Sprague Dawley Rats

Hypertension is highly prevalent in chronic kidney disease (CKD). Hydrogen sulfide (H2S) is an endogenously produced gasotransmitter with vasodilator properties. We, hence, investigated whether oral administration of sodium thiosulfate (STS), a clinically applicable H2S-based therapy, can exert a protective effect against hypertension in an adenine-induced CKD rat model. Eight-week-old male Sprague–Dawley rats were fed with 0.5% adenine chow for 3 weeks to induce CKD. After 1 week, the rats were divided into two groups: one without and one with STS (2 g/kg body weight/day) in drinking water for 2 weeks. Treatment with STS lowered systolic and diastolic blood pressure by 7 and 9 mm Hg, respectively. Renal H2S-generating enzyme expression was inhibited by CKD, while STS therapy increased plasma levels of H2S and thiosulfate. Additionally, restoration of nitric oxide bioavailability and rebalance of the renin–angiotensin system may contribute to the protective effects of STS. Our data suggest that the oral administration of STS improves hypertension in an adenine-induced CKD model, which brings us closer to the clinical translation of H2S-targeting therapy in CKD-induced hypertension.

Prevention of Fetal and Maternal Cyanide Toxicity from Nitroprusside with Coinfusion of Sodium Thiosulfate in Gravid Ewes

1997 ◽  
Vol 84 (5) ◽  
pp. 1121-1126 ◽  
Author(s):  
Steven C. Curry ◽  
Michael W. Carlton ◽  
Robert A. Raschke
Keyword(s):  
Sodium Thiosulfate ◽  
Cyanide Toxicity

Utility of Sodium Thiosulfate in Acute Cyanide Toxicity

2013 ◽  
Vol 61 (1) ◽  
pp. 124-125 ◽  
Author(s):  
Mae De La Calzada-Jeanlouie ◽  
Jaron Coombs ◽  
Nadia Shaukat ◽  
Dean Olsen
Keyword(s):  
Sodium Thiosulfate ◽  
Cyanide Toxicity

scholarly journals Intramuscular sodium tetrathionate as an antidote in a clinically relevant swine model of acute cyanide toxicity

2019 ◽  
Vol 58 (1) ◽  
pp. 29-35 ◽  
Author(s):  
Tara B. Hendry-Hofer ◽  
Alyssa E. Witeof ◽  
Patrick C. Ng ◽  
Sari B. Mahon ◽  
Matthew Brenner ◽  
...  
Keyword(s):  
Swine Model ◽  
Cyanide Toxicity

scholarly journals Intramuscular dimethyl trisulfide: efficacy in a large swine model of acute severe cyanide toxicity

2018 ◽  
Vol 57 (4) ◽  
pp. 265-270 ◽  
Author(s):  
Tara B. Hendry-Hofer ◽  
Alyssa E. Witeof ◽  
Dennean S. Lippner ◽  
Patrick C. Ng ◽  
Sari B. Mahon ◽  
...  
Keyword(s):  
Swine Model ◽  
Dimethyl Trisulfide ◽  
Cyanide Toxicity
Sign in / Sign up

Export Citation Format

Share Document