Dose-response analysis of the effects of persistent organic pollutants (POPs) on gene expression in human hepatocytes

2015 ◽  
Vol 11 (3) ◽  
pp. 323-334 ◽  
Author(s):  
Mi-Kyung Song ◽  
Jae-Chun Ryu
Keyword(s):  
Gene Expression ◽  
Organic Pollutants ◽  
Persistent Organic Pollutants ◽  
Dose Response ◽  
Human Hepatocytes ◽  
Response Analysis

scholarly journals Nonmonotonic Pathway Gene Expression Analysis Reveals Oncogenic Role of p27/Kip1 at Intermediate Dose

2017 ◽  
Vol 16 ◽  
pp. 117693511774013 ◽  
Author(s):  
Hien H Nguyen ◽  
Susan C Tilton ◽  
Christopher J Kemp ◽  
Mingzhou Song
Keyword(s):  
Gene Expression ◽  
Pathway Analysis ◽  
Dose Response ◽  
Response Analysis ◽  
Response Curves ◽  
Cancer Pathways ◽  
Pathway Gene ◽  
Mechanistic Basis ◽  
Functional Pathway ◽  
Squamous Cell Papilloma

The mechanistic basis by which the level of p27Kip1 expression influences tumor aggressiveness and patient mortality remains unclear. To elucidate the competing tumor-suppressing and oncogenic effects of p27Kip1 on gene expression in tumors, we analyzed the transcriptomes of squamous cell papilloma derived from Cdkn1b nullizygous, heterozygous, and wild-type mice. We developed a novel functional pathway analysis method capable of testing directional and nonmonotonic dose response. This analysis can reveal potential causal relationships that might have been missed by other nondirectional pathway analysis methods. Applying this method to capture dose-response curves in papilloma gene expression data, we show that several known cancer pathways are dominated by low-high-low gene expression responses to increasing p27 gene doses. The oncogene cyclin D1, whose expression is elevated at an intermediate p27 dose, is the most responsive gene shared by these cancer pathways. Therefore, intermediate levels of p27 may promote cellular processes favoring tumorigenesis—strikingly consistent with the dominance of heterozygous mutations in CDKN1B seen in human cancers. Our findings shed new light on regulatory mechanisms for both pro- and anti-tumorigenic roles of p27Kip1. Functional pathway dose-response analysis provides a unique opportunity to uncover nonmonotonic patterns in biological systems.

scholarly journals Fish Oil Contaminated with Persistent Organic Pollutants Induces Colonic Aberrant Crypt Foci Formation and Reduces Antioxidant Enzyme Gene Expression in Rats

2017 ◽  
Vol 147 (8) ◽  
pp. 1524-1530 ◽  
Author(s):  
Mee Young Hong ◽  
Eunha Hoh ◽  
Brian Kang ◽  
Rebecca DeHamer ◽  
Jin Young Kim ◽  
...  
Keyword(s):  
Gene Expression ◽  
Fish Oil ◽  
Antioxidant Enzyme ◽  
Organic Pollutants ◽  
Persistent Organic Pollutants ◽  
Aberrant Crypt Foci ◽  
Enzyme Gene

scholarly journals Analysis of the toxicogenomic effects of exposure to persistent organic pollutants (POPs) in Slovakian girls: Correlations between gene expression and disease risk

2012 ◽  
Vol 39 (1) ◽  
pp. 188-199 ◽  
Author(s):  
Partha Sarathi Mitra ◽  
Somiranjan Ghosh ◽  
Shizhu Zang ◽  
Dean Sonneborn ◽  
Irva Hertz-Picciotto ◽  
...  
Keyword(s):  
Gene Expression ◽  
Organic Pollutants ◽  
Persistent Organic Pollutants ◽  
Disease Risk

scholarly journals Automated Dose-Response Analysis of the Relative Hepatic Gene Expression Potency of TCDF in C57BL/6 Mice

2009 ◽  
Vol 112 (1) ◽  
pp. 221-228 ◽  
Author(s):  
Lyle D. Burgoon ◽  
Qi Ding ◽  
Alhaji N'jai ◽  
Ed Dere ◽  
Ashley R. Burg ◽  
...  
Keyword(s):  
Gene Expression ◽  
Dose Response ◽  
Response Analysis ◽  
Hepatic Gene Expression

Physiological Response to Persistent Organic Pollutants in Fish from Mountain Lakes:  Analysis of Cyp1A Gene Expression in Natural Populations ofSalmo trutta

2007 ◽  
Vol 41 (14) ◽  
pp. 5154-5160 ◽  
Author(s):  
Laia Quirós ◽  
Sergio Jarque ◽  
Reinhard Lackner ◽  
Pilar Fernández ◽  
Joan O. Grimalt ◽  
...  
Keyword(s):  
Gene Expression ◽  
Organic Pollutants ◽  
Persistent Organic Pollutants ◽  
Physiological Response ◽  
Natural Populations ◽  
Mountain Lakes
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