Better and greener: sustainable pharmaceutical manufacturing technologies for highly bioavailable solid dosage forms

2022 ◽  
Author(s):  
Serena Bertoni ◽  
Dritan Hasa ◽  
Beatrice Albertini ◽  
Beatrice Perissutti ◽  
Mario Grassi ◽  
...  
Keyword(s):  
Dosage Forms ◽  
Pharmaceutical Manufacturing ◽  
Solid Dosage Forms ◽  
Solid Dosage ◽  
Manufacturing Technologies

Advances in solid dosage form manufacturing technology

2007 ◽  
Vol 365 (1861) ◽  
pp. 2935-2949 ◽  
Author(s):  
Gavin P Andrews
Keyword(s):  
Dosage Form ◽  
Powder Processing ◽  
Dosage Forms ◽  
Oral Dosage ◽  
Pharmaceutical Companies ◽  
Solid Dosage Forms ◽  
Solid Dosage Form ◽  
Solid Dosage ◽  
Manufacturing Technologies ◽  
Hot Melt

Currently, the pharmaceutical and healthcare industries are moving through a period of unparalleled change. Major multinational pharmaceutical companies are restructuring, consolidating, merging and more importantly critically assessing their competitiveness to ensure constant growth in an ever-more demanding market where the cost of developing novel products is continuously increasing. The pharmaceutical manufacturing processes currently in existence for the production of solid oral dosage forms are associated with significant disadvantages and in many instances provide many processing problems. Therefore, it is well accepted that there is an increasing need for alternative processes to dramatically improve powder processing, and more importantly to ensure that acceptable, reproducible solid dosage forms can be manufactured. Consequently, pharmaceutical companies are beginning to invest in innovative processes capable of producing solid dosage forms that better meet the needs of the patient while providing efficient manufacturing operations. This article discusses two emerging solid dosage form manufacturing technologies, namely hot-melt extrusion and fluidized hot-melt granulation.

Extrusion-based 3D printing of oral solid dosage forms: Material requirements and equipment dependencies

2021 ◽  
Vol 598 ◽  
pp. 120361 ◽  
Author(s):  
S. Henry ◽  
A. Samaro ◽  
F.H. Marchesini ◽  
B. Shaqour ◽  
J. Macedo ◽  
...  
Keyword(s):  
3D Printing ◽  
Dosage Forms ◽  
Solid Dosage Forms ◽  
Solid Dosage ◽  
Material Requirements
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