Extrusion-based 3D printing of oral solid dosage forms: Material requirements and equipment dependencies

2021 ◽  
Vol 598 ◽  
pp. 120361 ◽  
Author(s):  
S. Henry ◽  
A. Samaro ◽  
F.H. Marchesini ◽  
B. Shaqour ◽  
J. Macedo ◽  
...  
Pharmaceutics ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 156
Author(s):  
Alperen Abaci ◽  
Christina Gedeon ◽  
Anna Kuna ◽  
Murat Guvendiren

Additive manufacturing (AM), also known as three-dimensional (3D) printing, enables fabrication of custom-designed and personalized 3D constructs with high complexity in shape and composition. AM has a strong potential to fabricate oral tablets with enhanced customization and complexity as compared to tablets manufactured using conventional approaches. Despite these advantages, AM has not yet become the mainstream manufacturing approach for fabrication of oral solid dosage forms mainly due to limitations of AM technologies and lack of diverse printable drug formulations. In this review, AM of oral tablets are summarized with respect to AM technology. A detailed review of AM methods and materials used for the AM of oral tablets is presented. This article also reviews the challenges in AM of pharmaceutical formulations and potential strategies to overcome these challenges.


2021 ◽  
Vol 22 ◽  
Author(s):  
Prasanna Kumar Desu ◽  
Balaji Maddiboyina ◽  
Vanitha K. ◽  
GSN Koteswara Rao ◽  
Anusha R. ◽  
...  

Three Dimensional (3D) Printing is a promising method for quick prototyping and manufacturing of any material. It is similar to photocopy or printing, where the new materials are formed on layers (3D) like its mother component. Following its growth and advancement in the 1980s, its application in pharmaceuticals is still limited. It has become one of the most innovative and influential tools serving as a technology of precise manufacturing of developed dosage forms from the last decade. The potential of 3D printing to produce drugs for precise measurement customized to specific patients' needs has shown the possibility of developing personalized medicines to novel dosage forms. The breakthrough allows the clear perception of the dosage structures on different shapes, sizes, and surfaces challenging to deliver using Designed conditions. There are different difficulties related to the correct utilization of 3D imprinting in the pharmaceutical Part, which ought to be defeated to abuse the extent of this technology. Recent advancements in the field of 3D printing technology used in the pharmaceutical industry mainly focused on different techniques for the fabrication of different dosage forms. The Food and Drug Administration's (FDA) recent approval of the first 3D prescription highlights possibilities for 3D printing innovation in the pharmaceutical drug supply field. This analysis assesses 3D printing advancement possibilities, particularly in the area of custom prescriptions. This technology can be regarded as the future of demand-produced, low-cost solid dosage forms, and helps minimize side effects due to overdose.


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