Establishment and characterization of a novel cell line, NCC-DDLPS2-C1, derived from a patient with dedifferentiated liposarcoma

Human Cell ◽  
2021 ◽  
Author(s):  
Rei Noguchi ◽  
Yuki Yoshimatsu ◽  
Takuya Ono ◽  
Akane Sei ◽  
Kaoru Hirabayashi ◽  
...  
Keyword(s):  
Cell Line ◽  
Dedifferentiated Liposarcoma

Establishment and characterization of NCC-DDLPS3-C1: a novel patient-derived cell line of dedifferentiated liposarcoma

Human Cell ◽  
2021 ◽  
Vol 34 (3) ◽  
pp. 1008-1018
Author(s):  
Ryuto Tsuchiya ◽  
Yuki Yoshimatsu ◽  
Rei Noguchi ◽  
Takuya Ono ◽  
Akane Sei ◽  
...  
Keyword(s):  
Cell Line ◽  
Dedifferentiated Liposarcoma

Establishment and characterization of NCC-DDLPS1-C1: a novel patient-derived cell line of dedifferentiated liposarcoma

Human Cell ◽  
2020 ◽  
Vol 34 (1) ◽  
pp. 260-270
Author(s):  
Ryuto Tsuchiya ◽  
Yuki Yoshimatsu ◽  
Rei Noguchi ◽  
Akane Sei ◽  
Fumitaka Takeshita ◽  
...  
Keyword(s):  
Cell Line ◽  
Dedifferentiated Liposarcoma

scholarly journals Establishment and Characterization of NCC-DDLPS4-C1: A Novel Patient-Derived Cell Line of Dedifferentiated Liposarcoma

2021 ◽  
Vol 11 (11) ◽  
pp. 1075
Author(s):  
Ryuto Tsuchiya ◽  
Yuki Yoshimatsu ◽  
Rei Noguchi ◽  
Yooksil Sin ◽  
Takuya Ono ◽  
...  
Keyword(s):  
Cell Line ◽  
Cell Lines ◽  
Large Scale ◽  
Dedifferentiated Liposarcoma ◽  
Basic Study ◽  
Therapeutic Drugs ◽  
Candidate Drug ◽  
Deacetylase Inhibitor ◽  
Cell Banks

Dedifferentiated liposarcoma (DDLPS) is a highly malignant sarcoma characterized by the co-amplification of MDM2 and CDK4. Although systemic chemotherapy is recommended for unresectable or metastatic cases, DDLPS is insensitive to conventional chemotherapy, leading to an unfavorable prognosis. Therefore, novel treatment methods are urgently required. Patient-derived cell lines are essential in preclinical studies. Recently, large-scale screening studies using a number of cell lines have been actively conducted for the development of new therapeutic drugs. However, the DDLPS cell line cannot be obtained from public cell banks owing to its rarity, hindering screening studies. As such, novel DDLPS cell lines need to be established. Accordingly, this study aimed to establish a novel DDLPS cell line from surgical specimens. The cell line was named NCC-DDLPS4-C1. NCC-DDLPS4-C1 cells retained copy number alterations corresponding to the original tumors. Further, the cells demonstrated constant growth, spheroid formation, and equivalent invasiveness to MG63 osteosarcoma cells. We also conducted drug screening and integrated the results with those of the previously reported DDLPS cell lines. Consequently, we identified the histone deacetylase inhibitor romidepsin as a novel candidate drug. In conclusion, the NCC-DDLPS4-C1 cell line is a useful tool for the basic study of DDLPS.

Establishment and characterization of a novel dedifferentiated liposarcoma cell line, NDDLS-1

2011 ◽  
Vol 61 (8) ◽  
pp. 461-468 ◽  
Author(s):  
Takashi Ariizumi ◽  
Akira Ogose ◽  
Hiroyuki Kawashima ◽  
Tetsuo Hotta ◽  
Guidong Li ◽  
...  
Keyword(s):  
Cell Line ◽  
Dedifferentiated Liposarcoma

Characterization of oxytocin receptor in a human granulosa cell line

1998 ◽  
Vol 5 (1) ◽  
pp. 106A-106A
Author(s):  
J COPLAND ◽  
M ZLATMK ◽  
K IVES ◽  
M SOLOFF
Keyword(s):  
Cell Line ◽  
Granulosa Cell ◽  
Oxytocin Receptor ◽  
Human Granulosa Cell

Establishment and Characterization of a Human Glioblastoma Cell Line Which Expresses Somatostatin and its Functional Receptor

1999 ◽  
Vol 11 (3) ◽  
pp. 215-222
Author(s):  
Nobuo HIROTA ◽  
Kiyoshi MATSUMOTO ◽  
Shigeki SUNAGA ◽  
Masataka IIDA ◽  
Hiroshi SAKAGAMI ◽  
...  
Keyword(s):  
Cell Line ◽  
Glioblastoma Cell Line ◽  
Glioblastoma Cell ◽  
Human Glioblastoma ◽  
Human Glioblastoma Cell Line ◽  
Human Glioblastoma Cell ◽  
Functional Receptor

Characterization of a bovine intestinal myofibroblast cell line and stimulation using phytoglycogen-based nanoparticles bound to inosine monophosphate

2021 ◽  
Vol 57 (1) ◽  
pp. 86-94
Author(s):  
K. Jenik ◽  
T. N. Alkie ◽  
E. Moore ◽  
J. D. Dejong ◽  
L. E. J. Lee ◽  
...  
Keyword(s):  
Cell Line ◽  
Inosine Monophosphate
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