A long-term survival case of Erdheim–Chester disease on maintenance hemodialysis

2022 ◽  
Author(s):  
Ryo Konishi ◽  
Takuya Morinishi ◽  
Koji Takaori ◽  
Yuta Iwamoto ◽  
Makiko Kondo ◽  
...  
Keyword(s):  
Maintenance Hemodialysis ◽  
Term Survival ◽  
Long Term Survival ◽  
Erdheim Chester Disease ◽  
Erdheim Chester ◽  
Chester Disease ◽  
Survival Case

scholarly journals Erdheim–Chester disease multisystemic manifestations and long term survival with corticosteroid therapy

2008 ◽  
Vol 1 (2) ◽  
pp. 126-130
Author(s):  
Kemal Can Tertemiz ◽  
Can Sevinc ◽  
Burcin Tuna ◽  
Vasfi Karatosun ◽  
Erkan Yilmaz ◽  
...  
Keyword(s):  
Corticosteroid Therapy ◽  
Term Survival ◽  
Long Term Survival ◽  
Erdheim Chester Disease ◽  
Erdheim Chester ◽  
Chester Disease

scholarly journals A Long-term Survival Case of Alpha-fetoprotein Producing Barrett Esophageal Adenocarcinoma

2009 ◽  
Vol 42 (4) ◽  
pp. 355-361 ◽  
Author(s):  
Yoshimasa Akashi ◽  
Yosuke Izumi ◽  
Tsuyoshi Kato ◽  
Akinori Miura
Keyword(s):  
Esophageal Adenocarcinoma ◽  
Alpha Fetoprotein ◽  
Term Survival ◽  
Long Term Survival ◽  
Survival Case

scholarly journals A LONG-TERM SURVIVAL CASE OF ADENOENDOCRINE CELL CARCINOMA OF THE PAPILLA OF VATER

2008 ◽  
Vol 69 (5) ◽  
pp. 1096-1100 ◽  
Author(s):  
Naomasa UESUGI ◽  
Takashi NAKAMURA ◽  
Satoshi SAITO ◽  
Norichika MATSUI ◽  
Katsura TANZAN ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Papilla Of Vater ◽  
Term Survival ◽  
Long Term Survival ◽  
Adenoendocrine Cell Carcinoma ◽  
Survival Case

scholarly journals A Long-term Survival Case of Pancreas Tail Cancer with Colonic Obstruction.

1996 ◽  
Vol 29 (3) ◽  
pp. 756-760
Author(s):  
Michiya Kobayashi ◽  
Kimio Matsuura ◽  
Keijiro Araki ◽  
Eisuke Kashiwai ◽  
Naoshige Tochika ◽  
...  
Keyword(s):  
Colonic Obstruction ◽  
Term Survival ◽  
Long Term Survival ◽  
Survival Case

scholarly journals Dual BRAF/MEK blockade restores CNS responses in BRAF-mutant Erdheim–Chester disease patients following BRAF inhibitor monotherapy

2020 ◽  
Vol 2 (1) ◽  
Author(s):  
Roei D Mazor ◽  
Ran Weissman ◽  
Judith Luckman ◽  
Liran Domachevsky ◽  
Eli L Diamond ◽  
...  
Keyword(s):  
Disease Progression ◽  
Therapeutic Strategy ◽  
Braf Inhibitor ◽  
Response To Therapy ◽  
Cns Disease ◽  
Erdheim Chester Disease ◽  
Braf Mutant ◽  
Erdheim Chester ◽  
Chester Disease

Abstract Background Erdheim–Chester disease (ECD), a rare inflammatory myeloid neoplasm, is known to be fundamentally reliant on the constitutive activation of the MAPK signaling pathway in the majority of patients. Consequently, inhibition of the V600E-mutant BRAF kinase has proven to be a safe and efficacious long-term therapeutic strategy for BRAF-mutant ECD patients. Nevertheless, in a subset of patients with CNS disease, the efficacy of long-term treatment may diminish, facilitating suboptimal responses or disease progression. Methods We retrospectively describe 3 BRAF-mutant ECD patients whose treatment with Vemurafenib was upgraded to Vemurafenib/Cobimetinib due to either disease progression, insufficient response, or unacceptable toxicity. CNS response to therapy was evaluated using magnetic resonance imaging (MRI) and extra-cranial disease was monitored using 18F-fludeoxyglucose positron emission tomography/computed tomography (PET/CT). Results Three patients with a mean age of 52.6 years were treated with Vemurafenib for a mean duration of 26.6 months (range: 6–52). Monotherapies were upgraded to Vemurafenib/Cobimetinib dual therapy. The combination therapy was administered for a mean duration of 21 months (range: 19–23). All patients exhibited clinical and neurological improvement. Regression of lesions on MRI was noted in 2 patients. Both patients characterized by a PET-avid disease responded to the biological treatment regimen with complete metabolic remissions. Conclusion Dual inhibition of BRAF and downstream MEK may be a safe and effective therapeutic strategy for BRAF-mutant ECD patients for whom BRAF inhibitor therapy proved insufficient and as such appropriate for the long-term management of CNS disease in ECD.

Metabolic and Hormonal Assessment of Patients on Maintenance Hemodialysis for 10 Years or More and Their Importance in Long-Term Survival

Nephron ◽  
1988 ◽  
Vol 49 (2) ◽  
pp. 107-113 ◽  
Author(s):  
Vincenzo Allegra ◽  
Francesco Amendolagine ◽  
Giacomo Mengozzi ◽  
Lucio Jesu ◽  
Alfonso Vasile
Keyword(s):  
Maintenance Hemodialysis ◽  
Term Survival ◽  
Long Term Survival

scholarly journals A Long-term Survival Case of Small Cell Lung Cancer in an HIV-infected Patient

2005 ◽  
Vol 35 (6) ◽  
pp. 349-352 ◽  
Author(s):  
Tetsuro Kato ◽  
Ryuji Ieki ◽  
Erika Saito ◽  
Tomohiro Ota ◽  
Kazumi Yuasa ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Infected Patient ◽  
Small Cell ◽  
Small Cell Lung ◽  
Term Survival ◽  
Long Term Survival ◽  
Survival Case
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