The Calibrated Phylogeny of the Drosophila fasciola Subgroup (D. repleta Group Wasserman) Indicates Neogene Diversification of Its Internal Branches

2017 ◽  
Vol 46 (5) ◽  
pp. 537-545 ◽  
Author(s):  
F F Franco ◽  
E C C Silva ◽  
D Y Barrios-Leal ◽  
F M Sene ◽  
M H Manfrin
Keyword(s):  
Repleta Group

scholarly journals Origin and Evolution of a New Gene Descended From alcohol dehydrogenase in Drosophila

Genetics ◽  
1997 ◽  
Vol 145 (2) ◽  
pp. 375-382
Author(s):  
David J Begun
Keyword(s):  
Molecular Evolution ◽  
Alcohol Dehydrogenase ◽  
Functional Divergence ◽  
Sequence Divergence ◽  
Origin And Evolution ◽  
Repleta Group ◽  
Adh Genes ◽  
New Gene ◽  
Terminal Amino ◽  
Adh Activity

Drosophila alcohol dehydrogenase (Adh) is highly conserved in size, organization, and amino acid sequence. Adh-ψ was hypothesized to be a pseudogene derived from an Adh duplication in the repleta group of Drosophila; however, several results from molecular analyses of this gene conflict with currently held notions of molecular evolution. Perhaps the most difficult observations to reconcile with the pseudogene hypothesis are that the hypothetical replacement sites of Adh-ψ evolve only slightly more quickly than replacement sites of closely related, functional Adh genes, and that the replacement sites of the pseudogenes evolve considerably more slowly than neighboring silent sites. The data have been presented as a paradox that challenges our understanding of the mechanisms underlying DNA sequence divergence. Here I show that Adh-ψ is actually a new, functional gene recently descended from an Adh duplication. This descendant recruited ∼60 new N-terminal amino acids, is considerably more basic than ADH, and is evolving at a faster rate than Adh. Furthermore, though the descendant is clearly functional, as inferred from molecular evolution and population genetic data, it retains no obvious ADH activity. This probably reflects functional divergence from its Adh ancestor.

scholarly journals Characterization of the structure and evolution of the Adh region of Drosophila hydei.

Genetics ◽  
1991 ◽  
Vol 127 (2) ◽  
pp. 355-366
Author(s):  
M Menotti-Raymond ◽  
W T Starmer ◽  
D T Sullivan
Keyword(s):  
Sequence Divergence ◽  
Drosophila Hydei ◽  
Repleta Group ◽  
Drosophila Mulleri ◽  
Duplication Events ◽  
Independent Duplication ◽  
The Difference ◽  
Upstream Exon ◽  
Complex Manner

Abstract Drosophila of the repleta group have a duplication of the gene which encodes alcohol dehydrogenase (ADH). We report the nucleotide sequence of an 8.4-kb region of genomic DNA of Drosophila hydei which includes the entire Adh region. Analysis of this sequence reveals similarity in organization to the Adh region of Drosophila mojavensis and Drosophila mulleri of the mulleri subgroup, with three genes ordered 5' to 3', Adh-psi, Adh-2, Adh-1. Deletion of a nucleotide in the second codon of each pseudogene suggests that the first Adh duplication occurred before the divergence of the hydei and mulleri subgroups. However, Adh-1 and Adh-2 of D. hydei are significantly more alike than Adh-1 and Adh-2 of D. mojavensis. Models to account for the difference in similarity between the coding genes were tested by orthologous and paralogous comparisons of the extent of sequence divergence. A model which proposes that independent duplication events generated Adh-1 and Adh-2 in the two lineages is supported by these data. The D. hydei pseudogene is transcribed and the transcript is processed in a complex manner. An intron of greater than 6.2 kb exists between the first "coding" exon and an upstream exon which is approximately 250 nucleotides in length.

THE EVOLUTIONARY HISTORY OF DROSOPHILA BUZZATII. III. CYTOGENETIC RELATIONSHIPS BETWEEN TWO SIBLING SPECIES OF THE BUZZATII CLUSTER

Genetics ◽  
1982 ◽  
Vol 101 (3-4) ◽  
pp. 503-518 ◽  
Author(s):  
A Ruiz ◽  
A Fontdevila ◽  
M Wasserman
Keyword(s):  
Salivary Gland ◽  
Sibling Species ◽  
Related Species ◽  
Evolutionary History ◽  
South American ◽  
Closely Related Species ◽  
Drosophila Buzzatii ◽  
Repleta Group ◽  
Chromosomal Data ◽  
History Of

ABSTRACT Drosophila buzzatii has been found sympatric in Argentina with a closely-related sibling species, D. serido. The biogeographical, reproductive and chromosomal data allow us to combine these species into an evolutionary unit, the buzzatii cluster. Salivary gland chromosomes also have been used to determine their phylogenetic relationships with other closely related species, showing that the buzzatii cluster species share two inversions—2d  2 and 2s  6—with the species of the martensis cluster. Both clusters arose from South American populations of the ancestor of the mulleri complex, and we propose to include D. buzzatii and D. serido in the mulleri complex of the repleta group.

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