scholarly journals Histological and Physiological Studies of the Effect of Bone Marrow-Derived Mesenchymal Stem Cells on Bleomycin Induced Lung Fibrosis in Adult Albino Rats

2020 ◽  
Author(s):  
Dina Mohamed Zakaria ◽  
Noha Mahmoud Zahran ◽  
Samia Abdel Aziz Arafa ◽  
Radwa Ali Mehanna ◽  
Rehab Ahmed Abdel-Moneim
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Lung Fibrosis ◽  
Albino Rats ◽  
Physiological Studies

The Anti-fibrotic and Anti-inflammatory Potential of Bone Marrow–Derived Mesenchymal Stem Cells and Nintedanib in Bleomycin-Induced Lung Fibrosis in Rats

Inflammation ◽  
2019 ◽  
Vol 43 (1) ◽  
pp. 123-134 ◽  
Author(s):  
E. S. Gad ◽  
A. A. A. Salama ◽  
M. F. El-Shafie ◽  
H. M. M. Arafa ◽  
R. M. Abdelsalam ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Lung Fibrosis ◽  
Anti Inflammatory

scholarly journals Bone marrow-derived mesenchymal stem cells combined with gonadotropin therapy restore postnatal oogenesis of chemo-ablated ovaries in rats via enhancing very small embryonic-like stem cells

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Nesrine Ebrahim ◽  
Hajir A. Al Saihati ◽  
Amani Shaman ◽  
Arigue A. Dessouky ◽  
Ayman Samir Farid ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Histopathological Examination ◽  
Primordial Germ Cells ◽  
Average Density ◽  
Albino Rats ◽  
Epithelial Surface ◽  
Group V ◽  
Transcript Levels

Abstract Background Very small embryonic-like stem cells (VSELs) are a rare population within the ovarian epithelial surface. They contribute to postnatal oogenesis as they have the ability to generate immature oocytes and resist the chemotherapy. These cells express markers of pluripotent embryonic and primordial germ cells. Objective We aimed to explore the capability of VSELs in restoring the postnatal oogenesis of chemo-ablated rat ovaries treated with bone marrow-derived mesenchymal stem cells (BM-MSCs) combined with pregnant mare serum gonadotropin (PMSG). Methods Female albino rats were randomly assigned across five groups: I (control), II (chemo-ablation), III (chemo-ablation + PMSG), IV (chemo-ablation + MSCs), and V (chemo-ablation + PMSG + MSCs). Postnatal oogenesis was assessed through measurement of OCT4, OCT4A, Scp3, Mvh, Nobox, Dazl4, Nanog, Sca-1, FSHr, STRA8, Bax, miR143, and miR376a transcript levels using qRT-PCR. Expression of selected key proteins were established as further confirmation of transcript expression changes. Histopathological examination and ovarian hormonal assessment were determined. Results Group V displayed significant upregulation of all measured genes when compared with group II, III or IV. Protein expression confirmed the changes in transcript levels as group V displayed the highest average density in all targeted proteins. These results were confirmed histologically by the presence of cuboidal germinal epithelium, numerous primordial, unilaminar, and mature Graafian follicles in group V. Conclusion VSELs can restore the postnatal oogenesis in chemo-ablated ovaries treated by BM-MSCs combined with PMSG.

The possible curative role of bone marrow-derived mesenchymal stem cells in bleomycin-induced skin changes in adult male albino rats

2021 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
Amal Abd-Elhafez ◽  
Maram Elkelany ◽  
Amany Mousa ◽  
Thorya El-deeb ◽  
Amira Kassab
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Adult Male ◽  
Albino Rats ◽  
Skin Changes

Characterization and differentiation potential of bone marrow-derived mesenchymal stem cells of male albino rats

2014 ◽  
Vol 37 (4) ◽  
pp. 667-676
Author(s):  
Soheir K. Ahmed ◽  
Somaya A. Mohammed ◽  
Gehan Khalaf ◽  
Heba Fikry
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Albino Rats ◽  
Differentiation Potential
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