The Neuropeptide Spexin Promotes the Osteoblast Differentiation of MC3T3-E1 Cells via the MEK/ERK Pathway and Bone Regeneration in a Mouse Calvarial Defect Model

2021 ◽  
Author(s):  
Freshet Assefa ◽  
Ju Ang Kim ◽  
Jiwon Lim ◽  
Sang-Hyeon Nam ◽  
Hong-In Shin ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Osteoblast Differentiation ◽  
Erk Pathway ◽  
Calvarial Defect ◽  
Defect Model

scholarly journals Bacterial cellulose-hydroxyapatite composites with osteogenic growth peptide (OGP) or pentapeptide OGP on bone regeneration in critical-size calvarial defect model

2015 ◽  
Vol 103 (10) ◽  
pp. 3397-3406 ◽  
Author(s):  
Suzane C. Pigossi ◽  
Guilherme J. P. L. de Oliveira ◽  
Livia S. Finoti ◽  
Rafael Nepomuceno ◽  
Luis Carlos Spolidorio ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Bacterial Cellulose ◽  
Critical Size ◽  
Calvarial Defect ◽  
Defect Model

Melatonin decorated 3D-printed beta-tricalcium phosphate scaffolds promoting bone regeneration in a rat calvarial defect model

2019 ◽  
Vol 7 (20) ◽  
pp. 3250-3259 ◽  
Author(s):  
Yali Miao ◽  
Yunhua Chen ◽  
Xiao Liu ◽  
Jingjing Diao ◽  
Naru Zhao ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Tricalcium Phosphate ◽  
Calvarial Defect ◽  
Defect Model ◽  
Beta Tricalcium Phosphate ◽  
3D Printed ◽  
Rat Calvarial Defect

3D-printed β-TCP scaffolds decorated with melatonin via dopamine mussel-inspired chemistry enhance the osteogenesis and in vivo bone regeneration.

Ultraviolet-Crosslinkable and Injectable Chitosan/Hydroxyapatite Hybrid Hydrogel for Critical Size Calvarial Defect Repair In Vivo

2015 ◽  
Vol 6 (4) ◽  
Author(s):  
Baoqiang Li ◽  
Lei Wang ◽  
Yu Hao ◽  
Daqing Wei ◽  
Ying Li ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Critical Size ◽  
Rabbit Model ◽  
Single Step ◽  
Calvarial Defect ◽  
Defect Model ◽  
Calvarial Bone ◽  
Hybrid Hydrogel ◽  
Defect Site

To promote bone regeneration in vivo using critical-size calvarial defect model, hybrid hydrogel was prepared by mixing chitosan with hydroxyapatite (HA) and ultraviolet (UV) irradiation in situ. The hydrosoluble, UV-crosslinkable and injectable N-methacryloyl chitosan (N-MAC) was synthesized via single-step N-acylation reaction. The chemical structure was confirmed by 1H-NMR and FTIR spectroscopy. N-MAC hydrogel presented a microporous structure with pore sizes ranging from 10 to 60 μm. Approximately 80% cell viability of N-MAC hydrogel against encapsulated 3T3 cell indicated that N-MAC is an emerging candidate for mimicking native extracellular matrix (ECM). N-MAC hydrogel hybridized with HA was used to accelerate regeneration of calvarial bone using rabbit model. The effects of hybrid hydrogels to promote bone regeneration were evaluated using critical size calvarial bone defect model. The healing effects of injectable hydrogels with/without HA for bone regeneration were investigated by analyzing X-ray image after 4 or 6 weeks. The results showed that the regenerated new bone for N-MAC 100 was significantly greater than N-MAC without HA and untreated controls. The higher HA content in N-MAC/HA hybrid hydrogel benefited the acceleration of bone regeneration. About 50% closure of defect site after 6 weeks postimplantation demonstrated potent osteoinductivity of N-MAC 100 UV-crosslinkable and injectable N-MAC/HA hybrid hydrogel would allow serving as a promising biomaterial for bone regeneration using the critical-size calvarial defect.

scholarly journals Determination of the optimal diabetes duration for bone regeneration experiments in an alloxan-induced diabetic rabbit calvarial defect model

2018 ◽  
Vol 48 (6) ◽  
pp. 383
Author(s):  
Sang-Hun Jeong ◽  
Bo Hyun Jung ◽  
Ki-Yeon Yoo ◽  
Heung-Sik Um ◽  
Beom-Seok Chang ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Diabetes Duration ◽  
Calvarial Defect ◽  
Defect Model ◽  
Diabetic Rabbit

Porous 3D Printed Scaffolds For Guided Bone Regeneration In a Rat Calvarial Defect Model

2020 ◽  
Vol 20 ◽  
pp. 100706 ◽  
Author(s):  
Hoang Phuc Dang ◽  
Cedryck Vaquette ◽  
Tara Shabab ◽  
Román A. Pérez ◽  
Ying Yang ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Guided Bone Regeneration ◽  
Calvarial Defect ◽  
Defect Model ◽  
3D Printed ◽  
Rat Calvarial Defect
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