Latent tuberculosis infection in transplant candidates: a systematic review and meta-analysis on TST and IGRA

Infection ◽  
2019 ◽  
Vol 47 (3) ◽  
pp. 353-361 ◽  
Author(s):  
Mohammad Javad Nasiri ◽  
Ali Pormohammad ◽  
Hossein Goudarzi ◽  
Masoud Mardani ◽  
Samin Zamani ◽  
...  
Keyword(s):  
Systematic Review ◽  
Latent Tuberculosis Infection ◽  
Meta Analysis ◽  
Latent Tuberculosis ◽  
Tuberculosis Infection ◽  
Transplant Candidates

scholarly journals Systematic review of latent tuberculosis infection research to inform programmatic management in Ireland

2021 ◽  
Author(s):  
James O’Connell ◽  
Eoghan de Barra ◽  
Samuel McConkey
Keyword(s):  
Systematic Review ◽  
Latent Tuberculosis Infection ◽  
Meta Analysis ◽  
Latent Tuberculosis ◽  
Risk Groups ◽  
Tuberculosis Infection ◽  
World Health ◽  
People Living With Hiv ◽  
Knowledge Gaps ◽  
Ltbi Screening

AbstractThe World Health Organisation (WHO) End Tuberculosis (TB) Strategy and the WHO Framework Towards Tuberculosis Elimination in Low Incidence Countries state that latent tuberculosis infection (LTBI) screening and treatment in selected high-risk groups is a priority action to eliminate TB. The European Centre for Disease Prevention and Control (ECDC) advises that this should be done through high-quality programmatic management, which they describe as having six key components. The research aim was to systematically review the literature to identify what is known about the epidemiology of LTBI and the uptake and completion of LTBI screening and treatment in Ireland to inform the programmatic management of LTBI nationally. A systematic literature review was performed according to a review protocol and reported in adherence with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) statement. Twenty-eight studies were eligible for inclusion and described LTBI screening or treatment performed in one of five contexts, pre-biologic or other immunosuppression screening, people living with HIV, TB case contacts, other vulnerable populations, or healthcare workers. The risk of bias across studies with regard to prevalence of LTBI was generally high. One study reported a complete cascade of LTBI care from screening initiation to treatment completion. This systematic review has described what published research there is on the epidemiology and cascade of LTBI care in Ireland and identified knowledge gaps. A strategy for addressing these knowledge gaps has been proposed.

scholarly journals Active and latent tuberculosis among refugees and asylum seekers: a systematic review and meta-analysis

2019 ◽  
Author(s):  
Raquel Proenca ◽  
Fernanda Mattos Souza ◽  
Mayara Lisboa Bastos ◽  
Rosangela Caetano ◽  
Jose Ueleres Braga ◽  
...  
Keyword(s):  
Systematic Review ◽  
Asylum Seekers ◽  
Latent Tuberculosis Infection ◽  
Meta Analysis ◽  
Country Of Origin ◽  
Forced Migration ◽  
Latent Tuberculosis ◽  
Tuberculosis Infection ◽  
Refugees And Asylum Seekers ◽  
Tuberculosis Prevalence

Abstract Background: In 2017, there were 68.5 million refugees, asylum seekers and persons displaced by wars and conflicts worldwide. Tuberculosis prevalence in the country of origin and adverse conditions endured during their journey may increase their risk for tuberculosis. Objective: We summarized the prevalence of active and latent tuberculosis infection among refugees and asylum seekers through a literature systematic review and meta-analysis by country of origin. Methods: Articles published in Medline, EMBASE, Web of Science and LILACS from 2000 to August 2017 were searched for, without language restriction. Two independent authors performed the study selection, data extraction and quality assessment. Random effect models were used to estimate pooled measures of active and latent tuberculosis prevalence. Sub-group analysis was performed according to country of origin and host continent. Results: Sixty-seven out of 767 identified papers were included, of which 16 entered the meta-analysis. Pooled prevalence of active and latent tuberculosis was 1% [95% confidence interval (CI)=1-2%] and 37% (95% CI=23-52%), respectively, both with high level of heterogeneity (I 2 =98.2% and 99.8%). Prevalence varied more according to countries of origin than host continent. Ninety-one per cent of studies reported routine screening of recently arrived immigrants in the host country; two-thirds confirmed tuberculosis bacteriologically. Many studies failed to provide relevant information. Conclusion: Tuberculosis is a major health problem among refugees and asylum seekers and should be given special attention in any host continent. To protect this vulnerable population, ensuring access to healthcare for early detection for prevention and treatment of the disease is essential. Key words: Forced migration. Mycobacterium Tuberculosis. Latent tuberculosis infection. Prevalence. Global health.

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