scholarly journals Longitudinal Analysis of the Choriocapillaris Using Optical Coherence Tomography Angiography Reveals Subretinal Fluid as a Substantial Confounder in Patients with Acute Central Serous Chorioretinopathy

2019 ◽  
Vol 8 (4) ◽  
pp. 599-610 ◽  
Author(s):  
Michael Reich ◽  
Daniel Böhringer ◽  
Bertan Cakir ◽  
Felicitas Bucher ◽  
Moritz Daniel ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Longitudinal Analysis ◽  
Central Serous Chorioretinopathy ◽  
Optical Coherence Tomography Angiography ◽  
Subretinal Fluid ◽  
Optical Coherence ◽  
Acute Central Serous Chorioretinopathy

scholarly journals Early alterations in retinal microvasculature on swept-source optical coherence tomography angiography in acute central serous chorioretinopathy

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Dominika Podkowinski ◽  
Bernhard Foessl ◽  
Luis de Sisternes ◽  
Sophie Beka ◽  
Anna-Sophie Mursch-Edlmayr ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Central Serous Chorioretinopathy ◽  
Subretinal Fluid ◽  
Retinal Blood Flow ◽  
Optical Coherence ◽  
Swept Source ◽  
Retinal Microvasculature ◽  
Significant Difference ◽  
Capillary Plexus ◽  
Acute Central Serous Chorioretinopathy

AbstractThe purpose of the study was to evaluate the retinal blood flow in patients with acute central serous chorioretinopathy (CSC) over an observational period of 1 month using swept-source optical coherence tomography (SS-OCTA), focusing especially on changes in the area of subretinal fluid (A-SRF). We correlated these findings with conventional indocyanine green angiography (ICGA). ICGA and SS-OCTA images were collected and analyzed of 12 eyes of 12 patients. The A-SRF was annotated and a qualitative analysis of choriocapillaris, the vessel density (VD) and perfusion density (PD) of the retinal superficial capillary plexus (SCP) and the deep capillary plexus (DCP) was performed in A-SRF and the unaffected remaining area (RA). The VD and PD in the DCP were statistically significantly lower in A-SRF than in the RA at baseline. (VD: p = 0.014; PD: p = 0.036). After 1 month, there was a statistically significant difference in the VD and PD of the DCP (VD: p = 0.015; PD: p = 0.014), and for the PD of the SCP between the A-SRF and the RA (p = 0.015), with lower values in the A-SRF. We found low perfused areas in choriocapillaris corresponding to hypofluorescent areas on ICGA. In conclusion there is a difference in VD and VD of the DCP in the area of SRF in acute CSC. These alterations may lead to a chronic change in the microvasculature and potentially to morphological changes.

scholarly journals Optical coherence tomography angiography findings in cystoid macular degeneration associated with central serous chorioretinopathy

2019 ◽  
Vol 103 (11) ◽  
pp. 1615-1618 ◽  
Author(s):  
Niroj Kumar Sahoo ◽  
Sai Bhakti Mishra ◽  
Claudio Iovino ◽  
Sumit Randhir Singh ◽  
Marion R Munk ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Macular Degeneration ◽  
Central Serous Chorioretinopathy ◽  
Optical Coherence Tomography Angiography ◽  
Subretinal Fluid ◽  
Patient Characteristics ◽  
Optical Coherence ◽  
Significant Difference ◽  
The Difference ◽  
Neurosensory Retinal Detachment

AimTo describe the optical coherence tomography (OCT) characteristics and to identify and analyse the incidence of choroidal neovascular (CNV) network seen on optical coherence tomography angiography (OCTA) in eyes with cystoid macular degeneration (CMD) associated with central serous chorioretinopathy (CSCR).MethodsThis was a retrospective, observational study of 29 eyes of 25 patients who were previously diagnosed as CSCR with CMD. Baseline patient characteristics, best-corrected visual acuity (BCVA), evidence of CNV network and its pattern on OCTA, distribution of CMD changes and OCT parameters, such as height of the neurosensory retinal detachment (NSD), presence of double layer sign, central macular thickness, were analysed. The eyes were classified into two groups depending on the presence or absence of CNV network on OCTA. BCVA, OCT parameters and CMD distribution were compared in the two groups at baseline using independent t-test.ResultA total of 13 (44.8 %) eyes had a CNV network, while only 9 out of the 13 eyes had pattern-I CNV. Among the eyes with CNV network (13 eyes), mean height of NSD was of 65.2±22.7 µ, whereas, among the eyes without CNV (16 eyes), it was 134.6±77.4 µ. The difference was statistically significant (p=0.013). There was no statistically significant difference between eye having a CNV and eyes without CNV in terms of other parameters.ConclusionA CNV network is seen in a large subset of patients with CMD in CSCR. A shallower subretinal fluid may point towards the presence of an underlying CNV network.

scholarly journals Changes in Retinal and Choroidal Vascularity in Eyes with Acute Central Serous Chorioretinopathy Using Optical Coherence Tomography Angiography

2019 ◽  
Author(s):  
Jingli Guo ◽  
Xinyi Ding ◽  
Yongjin Zhang ◽  
Gezhi Xu ◽  
Haixiang Wu
Keyword(s):  
Optical Coherence Tomography ◽  
Central Serous Chorioretinopathy ◽  
Optical Coherence Tomography Angiography ◽  
Case Series ◽  
Foveal Avascular Zone ◽  
Pigment Epithelial Detachment ◽  
Optical Coherence ◽  
Pigment Epithelial ◽  
Acute Central Serous Chorioretinopathy ◽  
The Mean

Abstract Background To compare the vascular changes of superficial capillary layer (SCP) and deep capillary layer (DCP) in retina and choriocapillary layer in eyes with acute central serous chorioretinopathy (CSCR) by optical coherence tomography angiography (OCTA) between at baseline and 3 months. Methods Prospective case series; Twelve patients (12 eyes) with acute CSCR at the baseline and 3 months were included. All patients underwent comprehensive ophthalmic examinations. Subfoveal choroidal thickness (SFCT) and central macular thickness (CMT) were evaluated by swept domain optical coherence tomography (SD-OCT). The foveal avascular zone (FAZ), the microvascular morphology and density of SCP and DCP, and the choroicapillary morphology were assessed by OCTA and Image J software. Results The mean CMT (p=0.018), the mean SFCT (p=0.013), the mean microvascular density of DCP (p<0.001) and choroicapillary layer (p<0.001) at baseline were different from the ones at 3 months. The density of DCP was increased and the areas of choriocapillaris flow signal void was shrinked at 3months in the process of self-resolve. Two eyes exhibited flat pigment epithelial detachment by OCT and OCTA demonstrated the formation of vascular in choroicapillary layer at 3 months. The en-face OCT can illstrate the area of ellipsoid zone (EZ) disruption. Conclusions OCTA enables the visualization of microvascular features of the DCP and choroidcapillary in eyes with acute CSCR in the process of self-resovle to help elucidate the pathophysiology. Flat pigment epithelial detachment presented by OCT in acute CSCR eyes can be revealed vascular structure in choroicapillary layer by OCTA. OCTA imaging seems to be a useful tool in the identification of acute CSCR.

scholarly journals Changes in Retinal and Choroidal Vascularity in Eyes with Acute Central Serous Chorioretinopathy Using Optical Coherence Tomography Angiography

2019 ◽  
Author(s):  
Jingli Guo ◽  
Xinyi Ding ◽  
Yongjin Zhang ◽  
Gezhi Xu ◽  
Haixiang Wu
Keyword(s):  
Optical Coherence Tomography ◽  
Central Serous Chorioretinopathy ◽  
Optical Coherence Tomography Angiography ◽  
Case Series ◽  
Foveal Avascular Zone ◽  
Optical Coherence ◽  
Signal Void ◽  
Acute Central Serous Chorioretinopathy ◽  
The Mean ◽  
Prospective Case Series

Abstract Background To compare the vascular changes of superficial capillary layer (SCP) and deep capillary layer (DCP) in retina and choriocapillary layer in eyes with acute central serous chorioretinopathy (CSC) by optical coherence tomography angiography (OCTA) between at baseline and 3 months. Methods Prospective case series; Twelve patients (12 eyes) with acute CSC at the baseline and 3 months were included. All patients underwent comprehensive ophthalmic examinations. Subfoveal choroidal thickness (SFCT) and central macular thickness (CMT) were evaluated by spectral domain optical coherence tomography (SD-OCT). The foveal avascular zone (FAZ), the microvascular morphology and density of SCP and DCP, and the choroicapillary morphology were assessed by OCTA or Image J software. All data in this study were presented as mean and standard deviations (SD) Results The mean±SD CMT (p=0.018), the mean±SD SFCT (p=0.013), the mean±SD microvascular density of DCP (p＜0.001) and choroicapillary layer (p＜0.001) at baseline were different from the ones at 3 months. The density of DCP was increased and choriocapillaris flow signal void was recovered at 3months in the process of self-resolve. Two eyes exhibited vascularized flat pigment epithelial detachment (FIPED) by OCTA. The en-face OCT can illstrate the area of the elongation of ellipsoid zone (EZ). Conclusions OCTA enables the visualization of microvascular features of the DCP and choroidcapillary in eyes with acute CSC in the process of self-resovle to help elucidate the pathophysiology. Vascularized FIPED could be obtained in acute CSC eyes by OCTA. OCTA imaging seems to be a useful tool in the identification of acute CSC.

scholarly journals Assessment of choriocapillary blood flow changes in response to half-dose photodynamic therapy in chronic central serous chorioretinopathy using optical coherence tomography angiography

2020 ◽  
Author(s):  
Juejun Liu ◽  
Changzheng Chen ◽  
Lu Li ◽  
Yishuang Xu ◽  
Zuohuizi Yi ◽  
...  
Keyword(s):  
Blood Flow ◽  
Optical Coherence Tomography ◽  
Photodynamic Therapy ◽  
Central Serous Chorioretinopathy ◽  
Optical Coherence Tomography Angiography ◽  
Optical Coherence ◽  
Chronic Central Serous Chorioretinopathy ◽  
Half Dose ◽  
Flow Changes

Abstract Background: Optical coherence tomography angiography (OCTA) is a newly developed imaging quantitative technique for analysis of choriocapillaris (CC) flow changes, thereby exploring the pathological mechanism of chronic central serous chorioretinopathy (CCSC) and the therapeutic effects of photodynamic therapy (PDT). In this study, we sought to quantify the blood flow changes in CC of CCSC patients receiving half-dose PDT using OCTA.Methods: A total of 28 affected eyes and 24 unaffected eyes of 26 CCSC patients receiving half-dose PDT, and 40 eyes of 20 healthy gender- and age-matched subjects were retrospectively enrolled in this study. The proportion of total areas of flow signal voids (FSV, %) in CC level of OCTA was assessed in both eyes of the CCSC patients at baseline and repeated in multiple sections at 1-week, 1-month, 3-month and 6-month intervals after PDT. In addition, the CC patterns in response to PDT at early stage and the subsequent morphologic changes were qualitatively documented using OCTA.Results: For affected eyes, FSV at 6-m follow-up was significantly lower than that at 1-m follow-up (p=0.036). When compared to normal control eyes, FSV in affected eyes was significantly higher at 1-m, 3-m and 6-m follow-up (p<0.05 for all), and FSV in unaffected eyes was significantly higher at baseline, 1-w, 1-m and 3-m follow-up (p<0.05 for all). Three CC patterns of early response to PDT were identified, including signs of recovery with more even flow signals, transient appearance of worse ischemia and secondary neovascularization within CC level.Conclusion: Abnormal CC flow attenuation remains in completely resolved eyes of CCSC patients treated with half-dose PDT.

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