scholarly journals Early alterations in retinal microvasculature on swept-source optical coherence tomography angiography in acute central serous chorioretinopathy

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Dominika Podkowinski ◽  
Bernhard Foessl ◽  
Luis de Sisternes ◽  
Sophie Beka ◽  
Anna-Sophie Mursch-Edlmayr ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Central Serous Chorioretinopathy ◽  
Subretinal Fluid ◽  
Retinal Blood Flow ◽  
Optical Coherence ◽  
Swept Source ◽  
Retinal Microvasculature ◽  
Significant Difference ◽  
Capillary Plexus ◽  
Acute Central Serous Chorioretinopathy

AbstractThe purpose of the study was to evaluate the retinal blood flow in patients with acute central serous chorioretinopathy (CSC) over an observational period of 1 month using swept-source optical coherence tomography (SS-OCTA), focusing especially on changes in the area of subretinal fluid (A-SRF). We correlated these findings with conventional indocyanine green angiography (ICGA). ICGA and SS-OCTA images were collected and analyzed of 12 eyes of 12 patients. The A-SRF was annotated and a qualitative analysis of choriocapillaris, the vessel density (VD) and perfusion density (PD) of the retinal superficial capillary plexus (SCP) and the deep capillary plexus (DCP) was performed in A-SRF and the unaffected remaining area (RA). The VD and PD in the DCP were statistically significantly lower in A-SRF than in the RA at baseline. (VD: p = 0.014; PD: p = 0.036). After 1 month, there was a statistically significant difference in the VD and PD of the DCP (VD: p = 0.015; PD: p = 0.014), and for the PD of the SCP between the A-SRF and the RA (p = 0.015), with lower values in the A-SRF. We found low perfused areas in choriocapillaris corresponding to hypofluorescent areas on ICGA. In conclusion there is a difference in VD and VD of the DCP in the area of SRF in acute CSC. These alterations may lead to a chronic change in the microvasculature and potentially to morphological changes.

scholarly journals Changes in the Retinal Microvasculature Measured Using Optical Coherence Tomography Angiography According to Age

2020 ◽  
Vol 9 (3) ◽  
pp. 883 ◽  
Author(s):  
Seung Hun Park ◽  
Heeyoon Cho ◽  
Sun Jin Hwang ◽  
Beomseo Jeon ◽  
Mincheol Seong ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Foveal Avascular Zone ◽  
Vascular Density ◽  
Inner Plexiform Layer ◽  
Optical Coherence ◽  
Cross Sectional ◽  
Swept Source ◽  
Age Related ◽  
Retinal Microvasculature ◽  
Significant Difference

In this cross-sectional study, we examined age-related changes in the retinal vessels of 100 healthy participants, aged from 5 to 80 years, and divided into four groups (G1, under 20 years of age; G2, from 20 to 39 years of age; G3, from 40 to 59 years of age; G4, age 60 years or older). All subjects underwent swept-source optical coherence tomography (SS-OCT) and OCT angiography (OCTA). The vascular density (VD) of the superficial (SCP) and deep capillary plexus (DCP), and choriocapillaris (CCP) were measured using OCTA. The vascular density of each capillary layer, foveal avascular zone (FAZ) area, ganglion cell-inner plexiform layer (GC-IPL) thickness, retinal thickness (RT), and choroidal thickness (CT) were compared between age groups. Most OCT variables were correlated with OCTA variables. The FAZ area; VD of the SCP, DCP, and CCP; GC-IPL thickness; RT; and CT showed significant difference (p < 0.001) between G1 + G2 and G3 + G4, except for central GC-IPL thickness (p = 0.14) and central RT (p = 0.25). Density of the retinal capillary vasculature reduced and FAZ area increased after age 40, which represents the onset of middle age.

scholarly journals A pilot study of scleral thickness in central serous chorioretinopathy using anterior segment optical coherence tomography

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yun Ji Lee ◽  
Yeon Jeong Lee ◽  
Jae Yeon Lee ◽  
Suhwan Lee
Keyword(s):  
Optical Coherence Tomography ◽  
Central Serous Chorioretinopathy ◽  
Anterior Segment ◽  
Venous Drainage ◽  
Enhanced Depth Imaging ◽  
Control Group ◽  
Study Group ◽  
Optical Coherence ◽  
Swept Source ◽  
Significant Difference

AbstractThe aim of this study is to compare the scleral thickness of central serous chorioretinopathy (CSC) eyes with controls using anterior segment optical coherence tomography (AS OCT). This prospective case control study included 15 patients (15 eyes) with CSC and 15 age and gender matched healthy subjects. All subjects underwent spectral domain OCT with enhanced depth imaging and swept source AS OCT of temporal sclera. We investigated difference in scleral thickness between the two groups and relationship between choroidal and scleral thickness. Among the 15 eyes in the study group, 1 eye had acute CSC, 4 had recurrent CSC, 7 had inactive CSC, and 3 had chronic CSC. There was no significant difference in terms of age, gender, axial length and spherical equivalent between the two groups. The choroidal and scleral thickness of the study group were significantly greater than those of the control group (P < 0.001, P = 0.034). Choroidal thickness was positively correlated with scleral thickness (P = 0.031). A thick sclera along with a thick choroid were demonstrated in CSC eyes using AS OCT. Scleral characteristics might be involved in the pathogenesis of CSC by affecting outflow resistance of venous drainage in choroidal circulation.

Wide-field swept-source optical coherence tomography angiography in the assessment of retinal microvasculature and choroidal thickness in patients with myopia

2021 ◽  
pp. bjophthalmol-2021-319540
Author(s):  
Jade Y. Moon ◽  
Itika Garg ◽  
Ying Cui ◽  
Raviv Katz ◽  
Ying Zhu ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Choroidal Thickness ◽  
Optical Coherence Tomography Angiography ◽  
Foveal Avascular Zone ◽  
Systemic Hypertension ◽  
Wide Field ◽  
Optical Coherence ◽  
Swept Source ◽  
Retinal Microvasculature ◽  
Capillary Plexus

Background/aimsPathological myopia (PM) is a leading cause of blindness worldwide. We aimed to evaluate microvascular and chorioretinal changes in different stages of myopia with wide-field (WF) swept-source (SS) optical coherence tomography angiography (OCTA).MethodsThis prospective cross-sectional observational study included 186 eyes of 122 patients who had undergone imaging between November 2018 and October 2020. Vessel density (VD) and vessel skeletonised density (VSD) of superficial capillary plexus, deep capillary plexus and whole retina, as well as foveal avascular zone parameters, retinal thickness (RT) and choroidal thickness (CT), were calculated.ResultsThis study evaluated 75 eyes of 48 patients with high myopia (HM), 43 eyes of 31 patients with mild to moderate myopia and 68 eyes of 53 age-matched controls. Controlling for age and the presence of systemic hypertension, we found that HM was associated with decrease in VD and VSD in all layers on 12×12 mm² scans. Furthermore, HM was associated with a VD and VSD decrease in every Early Treatment Diabetic Retinopathy Study grid, with a larger decrease temporally (βVD=−0.39, βVSD=−10.25, p<0.01). HM was associated with decreased RT and CT. Reduction in RT was outside the macular region, while reduction in CT was in the macular region.ConclusionUsing WF SS-OCTA, we identified reduction in microvasculature and structural changes associated with myopia. Decrease in VD and VSD was greater in the temporal quadrant, and reductions in RT and CT were uneven across the retina. Further work may help identify risk factors for the progression of PM and associated vision-threatening complications.

scholarly journals Optical coherence tomography angiography findings in cystoid macular degeneration associated with central serous chorioretinopathy

2019 ◽  
Vol 103 (11) ◽  
pp. 1615-1618 ◽  
Author(s):  
Niroj Kumar Sahoo ◽  
Sai Bhakti Mishra ◽  
Claudio Iovino ◽  
Sumit Randhir Singh ◽  
Marion R Munk ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Macular Degeneration ◽  
Central Serous Chorioretinopathy ◽  
Optical Coherence Tomography Angiography ◽  
Subretinal Fluid ◽  
Patient Characteristics ◽  
Optical Coherence ◽  
Significant Difference ◽  
The Difference ◽  
Neurosensory Retinal Detachment

AimTo describe the optical coherence tomography (OCT) characteristics and to identify and analyse the incidence of choroidal neovascular (CNV) network seen on optical coherence tomography angiography (OCTA) in eyes with cystoid macular degeneration (CMD) associated with central serous chorioretinopathy (CSCR).MethodsThis was a retrospective, observational study of 29 eyes of 25 patients who were previously diagnosed as CSCR with CMD. Baseline patient characteristics, best-corrected visual acuity (BCVA), evidence of CNV network and its pattern on OCTA, distribution of CMD changes and OCT parameters, such as height of the neurosensory retinal detachment (NSD), presence of double layer sign, central macular thickness, were analysed. The eyes were classified into two groups depending on the presence or absence of CNV network on OCTA. BCVA, OCT parameters and CMD distribution were compared in the two groups at baseline using independent t-test.ResultA total of 13 (44.8 %) eyes had a CNV network, while only 9 out of the 13 eyes had pattern-I CNV. Among the eyes with CNV network (13 eyes), mean height of NSD was of 65.2±22.7 µ, whereas, among the eyes without CNV (16 eyes), it was 134.6±77.4 µ. The difference was statistically significant (p=0.013). There was no statistically significant difference between eye having a CNV and eyes without CNV in terms of other parameters.ConclusionA CNV network is seen in a large subset of patients with CMD in CSCR. A shallower subretinal fluid may point towards the presence of an underlying CNV network.

scholarly journals Correlation of retinal changes with choroidal changes in acute and recurrent central serous chorioretinopathy assessed by swept-source optical coherence tomography

2020 ◽  
Vol 12 ◽  
pp. 251584141989982
Author(s):  
Durgasri Jaisankar ◽  
Meenakshi Kumar ◽  
Pukhraj Rishi ◽  
Sumeer Singh ◽  
Rajiv Raman
Keyword(s):  
Optical Coherence Tomography ◽  
Layer Thickness ◽  
Central Serous Chorioretinopathy ◽  
Choroidal Thickness ◽  
Retinal Layer ◽  
Optical Coherence ◽  
Swept Source ◽  
Acute Group ◽  
Significant Difference

Purpose: To evaluate affected choroidal regions and corresponding retinal changes in acute and recurrent central serous chorioretinopathy using swept-source optical coherence tomography. Methods: The foveal and subfoveal choroidal thicknesses were measured with swept-source optical coherence tomography. The retina was divided into five zones on the swept-source optical coherence tomography image based on baseline choroidal thickness being <100, 100–199, 200–299, 300–399 and ⩾400 μm. The retinal and choroidal thicknesses in the same five regions were evaluated during follow-up. The measurements were then compared between baseline (when central serous chorioretinopathy was active) and follow-up (after complete resolution of disease). Results: At baseline, in the acute group, the mean outer retinal layer thickness was significantly higher in areas with thicker choroid and lower in areas with thinner choroid. No such change was noticed in the recurrent group. In the acute group, the overall retinal thickness from baseline to follow-up decreased from 269.84 to 251.9 µm, ganglion cell layer thickness decreased from 107.14 to 101.28 µm, retinal nerve fibre layer thickness decreased from 56.96 to 49.33 µm, and no significant difference was noted in choroidal thickness. In the recurrent group, choroidal thickness significantly increased from 254.58 to 262.55 µm and ganglion cell layer decreased from 103.43 to 94.01 µm. No significant difference was noted in overall retina and retinal nerve fibre layer. Reduction in choroidal and retinal layer thicknesses was better in eyes which underwent laser treatment than the observation group. Conclusion: Swept-source optical coherence tomography might serve as an important non-invasive tool for both evaluating the extent of pathology and to predict the recurrence rate.

Intra- and Interdevice Deviation of Optical Coherence Tomography Angiography

2019 ◽  
Vol 236 (04) ◽  
pp. 551-554 ◽  
Author(s):  
Stefan Trachsler ◽  
Arthur Baston ◽  
Marcel Menke
Keyword(s):  
Optical Coherence Tomography ◽  
Healthy Subjects ◽  
Optical Coherence Tomography Angiography ◽  
Foveal Avascular Zone ◽  
Optical Coherence ◽  
Swept Source ◽  
Significant Difference ◽  
Capillary Plexus ◽  
Swept Source Oct ◽  
Scan Modes

Abstract Purpose To compare 4 optical coherence tomography-angiography (OCT-A) devices for foveal avascular zone (FAZ) measurements in healthy subjects. Methods The central retinas of 24 eyes of 12 healthy subjects were scanned with 4 different OCT-A devices (Optovue RTVue-XR, Zeiss Cirrus 5000-HD-OCT, a prototype Spectralis OCT2, Heidelberg Engineering, and Topcon DRI-OCT Triton Swept-source OCT). For the Topcon, Zeiss, and Optovue devices, 3-mm and 6-mm scans were performed. The Heidelberg device only provided 4-mm scans. En-face OCT-A images of the superficial and deep capillary plexus of the macular area were generated. The FAZ areas were measured and compared. Results Twenty-four healthy eyes were included. OCT-A devices showed significant differences in FAZ measurements. The Zeiss OCT-A device measured the smallest values for foveal avascular area (mean 218.7 mm2), followed by the Optovue device (229.6 mm2), the Topcon device (239.3 mm2), and the Heidelberg device (250.4 mm2). Differences were statistically significant for following devices: Heidelberg versus Optovue (p < 0.001), Heidelberg versus Zeiss (p < 0.001), Topcon versus Zeiss (p < 0.001), and Optovue versus Zeiss (p = 0.046). For the Optovue device, FAZ measurements were significantly different between 3 mm (mean 220 mm2) and 6 mm (mean 239.3 mm2, p = 0.007) scans. All other devices showed no significant difference within scan modes. Conclusion Current OCT-A devices provide images that allow such measurements, but values showed significant differences between devices and, for the Optovue instrument, even within scan modes. The data for OCTA measurements cannot be transferred interchangeably between the devices. Therefore, a patient should always be measured with the same device.

Evaluation of the changes in choroidal thickness in patients with central serous chorioretinopathy as measured by optical coherence tomography

2021 ◽  
Vol 2 (1) ◽  
pp. 31-36
Author(s):  
Ragai Magdy Hatata ◽  
◽  
Sherin Hassan Sadek ◽  
Keyword(s):  
Optical Coherence Tomography ◽  
Central Serous Chorioretinopathy ◽  
Choroidal Thickness ◽  
Subretinal Fluid ◽  
Base Line ◽  
Optical Coherence ◽  
Significant Difference ◽  
And Control ◽  
Fellow Eyes

AIM: To study the changes in choroidal thickness in central serous chorioretinopathy (CSCR) over a 3mo follow-up using spectral domain optical coherence tomography (SD-OCT). METHODS: This prospective study included 60 eyes, both eyes of 20 patients (mean age: 33.65±5.24y) with classic acute unilateral central serous chorioretinopathy and normal fellow eye and 20 eyes as healthy controls. Fluorescein angiography and OCT were done. The subfoveal choroidal thickness (SFCT), central macular thickness (CMT), 1000 μm temporal and nasal to the centre of the fovea and the subretinal fluid were measured. RESULTS: There was a statistically significant difference in SFCT among the three groups at the three different locations. SFCT in eyes with CSCR (372.40±34.39 μm) was significantly greater than that in each of the unaffected fellow eyes (302.10±8.9 μm) and control eyes (279.80±14.49 μm) at the base line and after 3mo follow-up. The mean CMT in CSCR was 317±141.86 μm, with a statistically significant positive correlation between SFCT and CMT. CONCLUSION: The increase in the choroidal thickness at different locations as well as hyper-dilated and hyper-permeable vessels known as “pachychoroid” seems to play an important role in a broad spectrum of diseases that includes central serous chorioretinopathy.

scholarly journals Retinal Optical Coherence Tomography Angiography Findings of Acute Anterior Uveitis

2021 ◽  
Author(s):  
Gülay Yalçınkaya ◽  
Çiğdem Altan ◽  
Berna Başarır ◽  
İhsan Çakır
Keyword(s):  
Optical Coherence Tomography ◽  
Anterior Uveitis ◽  
Optical Coherence Tomography Angiography ◽  
Foveal Avascular Zone ◽  
Control Group ◽  
Optical Coherence ◽  
Foveal Thickness ◽  
Retinal Microvasculature ◽  
Significant Difference ◽  
Capillary Plexus

Abstract Purpose: To evaluate the changes in retinal microvasculature in eyes with anterior uveitis (AU) using optical coherence tomography angiography.Methods: Foveal avascular zone (FAZ) of superficial capillary plexus (SCP) and deep capillary plexus (DCP), vessel density (VD) of SCP, DCP, and choriocapillaris, and central macular thickness (CMT) and central foveal thickness (CFT) were calculated from 34 healthy and 41 uveitic eyes. The parameters were compared between the two groups.Results: The deep FAZ was significantly lower in the eyes with AU during the attack than after recovery and the control group (p=0.001 and p=0.003, respectively). The VD in deep capillary plexus (DCP) in eyes with AU during the attack was significantly higher than the control group (p=0.048). The VD in the foveal sector of DCP in eyes with AU during the attack and after recovery was significantly higher than the control group (p=0.001 and p=0.031, respectively). There was no significant difference regarding CMT, CFT, VDs of each segment and each sector, and superficial and deep FAZ between eyes with first uveitis attack and those with recurrent uveitis during the attack and after recovery (p>0.05). Conclusion: The results of this study show that there is a reduction in the FAZ and an increase in the VD of the DCP of the retina during active AU, and these findings are reversible. Acute AU may affect the macular microvasculature, which is usually temporary, especially in the DCP.

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