scholarly journals Efficacy of Pitolisant 20 mg in Reducing Excessive Daytime Sleepiness and Fatigue in Patients with Obstructive Sleep Apnoea Syndrome: An Individual Patient Data Meta-analysis

2021 ◽  
Author(s):  
Philippe Lehert
Keyword(s):  
Obstructive Sleep Apnoea ◽  
Excessive Daytime Sleepiness ◽  
Daytime Sleepiness ◽  
Individual Patient Data ◽  
Meta Analysis ◽  
Sleep Apnoea ◽  
Patient Data ◽  
Obstructive Sleep Apnoea Syndrome ◽  
Sleep Apnoea Syndrome ◽  
Obstructive Sleep

Daytime sleepiness in patients with obstructive sleep apnoea syndrome and its correlation to insulin resistance

2016 ◽  
Author(s):  
Dimosthenis Lykouras ◽  
Kleanthis Theodoropoulos ◽  
Olga Lagiou ◽  
Michail Lykouras ◽  
Fotios Sampsonas ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Obstructive Sleep Apnoea ◽  
Daytime Sleepiness ◽  
Sleep Apnoea ◽  
Obstructive Sleep Apnoea Syndrome ◽  
Sleep Apnoea Syndrome ◽  
Obstructive Sleep

Exercise capacity in obstructive sleep apnoea patients: An individual patient data and aggregate meta-analysis

2019 ◽  
Author(s):  
Mathieu Berger ◽  
Christopher E. Kline ◽  
Felipe X. Cepeda ◽  
Camila F. Rizzi ◽  
Céline Chapelle ◽  
...  
Keyword(s):  
Exercise Capacity ◽  
Obstructive Sleep Apnoea ◽  
Individual Patient Data ◽  
Meta Analysis ◽  
Sleep Apnoea ◽  
Patient Data ◽  
Obstructive Sleep

scholarly journals Contribution of obstructive sleep apnoea to arterial stiffness: a meta-analysis using individual patient data

Thorax ◽  
2018 ◽  
Vol 73 (12) ◽  
pp. 1146-1151 ◽  
Author(s):  
Marie Joyeux-Faure ◽  
Renaud Tamisier ◽  
Jean-Christian Borel ◽  
Sandrine Millasseau ◽  
Louis-Marie Galerneau ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Arterial Stiffness ◽  
Systolic Blood Pressure ◽  
Obstructive Sleep Apnoea ◽  
Individual Patient Data ◽  
Meta Analysis ◽  
Univariate Analysis ◽  
Sleep Apnoea ◽  
Patient Data ◽  
Obstructive Sleep

BackgroundArterial stiffness, measured by pulse wave velocity (PWV), is a strong independent predictor of late cardiovascular events and mortality. It is recognised that obstructive sleep apnoea (OSA) is associated with cardiovascular comorbidities and mortality. Although previous meta-analyses concluded that PWV is elevated in OSA, we feel that an individual patient data analysis from nine relatively homogeneous studies could help answer: to what extent does OSA drive arterial stiffness?MethodsIndividual data from well-characterised patients referred for suspicion of OSA, included in nine studies in which carotid–femoral PWV was measured using a Complior device, were merged for an individual patient data meta-analysis.Results893 subjects were included (age: 56±11 (mean±SD), 72% men, 84% with confirmed OSA). Body Mass Index varied from 15 to 81 kg/m2 (30±7 kg/m2). PWV ranged from 5.3 to 20.5 m/s (10.4±2.3 m/s). In univariate analysis, log(PWV) was strongly related to age, gender, systolic blood pressure, presence of type 2 diabetes (all p<0.01) as well as to dyslipidaemia (p=0.03) and an Epworth Sleepiness Scale score ≥9 (p=0.04), whereas it was not related to obesity (p=0.54), a severe Apnoea–Hypopnoea Index (p=0.14), mean nocturnal saturation (p=0.33) or sleep time with oxygen saturation below 90% (p=0.47). In multivariable analysis, PWV was independently associated with age, systolic blood pressure and diabetes (all p<0.01), whereas severe OSA was not significantly associated with PWV.ConclusionOur individual patient meta-analysis showed that elevated arterial stiffness in patients with OSA is driven by conventional cardiovascular risk factors rather than apnoea parameters.

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