Physiologically Based Pharmacokinetic Modelling to Describe the Pharmacokinetics of Risperidone and 9-Hydroxyrisperidone According to Cytochrome P450 2D6 Phenotypes

Clinical Pharmacokinetics ◽

10.1007/s40262-019-00793-x ◽

2019 ◽

Vol 59 (1) ◽

pp. 51-65 ◽

Author(s):

Lisa Alina Kneller ◽

Francisco Abad-Santos ◽

Georg Hempel

Keyword(s):

Cytochrome P450 ◽

Cytochrome P450 2D6 ◽

Pharmacokinetic Modelling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based Pharmacokinetic Modelling ◽

Physiologically Based ◽

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14 Physiologically based pharmacokinetic modelling of risperidone and 9-hydroxyrisperidone to determine cytochrome P450 2D6 phenotypes in schizophrenia patients

10.1055/s-0040-1710122 ◽

2020 ◽

Author(s):

LA Kneller ◽

G Hempel

Keyword(s):

Cytochrome P450 ◽

Cytochrome P450 2D6 ◽

Pharmacokinetic Modelling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based Pharmacokinetic Modelling ◽

Physiologically Based ◽

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Modelled plasma concentrations of pemafibrate with co-administered typical cytochrome P450 inhibitors clopidogrel, fluconazole or clarithromycin predicted by physiologically based pharmacokinetic modelling in virtual populations

Xenobiotica ◽

10.1080/00498254.2020.1793030 ◽

2020 ◽

Vol 50 (12) ◽

pp. 1413-1422

Author(s):

Shin-ichiro Ogawa ◽

Makiko Shimizu ◽

Hiroshi Yamazaki

Keyword(s):

Cytochrome P450 ◽

Plasma Concentrations ◽

Pharmacokinetic Modelling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based Pharmacokinetic Modelling ◽

Physiologically Based ◽

P450 Inhibitors

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Application of unbound liver-to-plasma concentration ratio to quantitative projection of cytochrome P450-mediated drug–drug interactions using physiologically based pharmacokinetic modelling approach

Xenobiotica ◽

10.1080/00498254.2018.1547461 ◽

2019 ◽

Vol 49 (11) ◽

pp. 1251-1259 ◽

Author(s):

Shinji Iwasaki ◽

Yohei Kosugi ◽

Andy Z.X. Zhu ◽

Sayaka Nakagawa ◽

Noriyasu Sano ◽

...

Keyword(s):

Cytochrome P450 ◽

Plasma Concentration ◽

Drug Interactions ◽

Concentration Ratio ◽

Pharmacokinetic Modelling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based Pharmacokinetic Modelling ◽

Physiologically Based ◽

Plasma Concentration Ratio ◽

Modelling Approach

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Physiologically Based Pharmacokinetic Modelling of Cytochrome P450 2C9-Related Tolbutamide Drug Interactions with Sulfaphenazole and Tasisulam

European Journal of Drug Metabolism and Pharmacokinetics ◽

10.1007/s13318-017-0447-5 ◽

2017 ◽

Vol 43 (3) ◽

pp. 355-367 ◽

Author(s):

Everett J. Perkins ◽

Maria Posada ◽

P. Kellie Turner ◽

Jill Chappell ◽

Wee Teck Ng ◽

...

Keyword(s):

Cytochrome P450 ◽

Drug Interactions ◽

Pharmacokinetic Modelling ◽

Cytochrome P450 2C9 ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based Pharmacokinetic Modelling ◽

Physiologically Based

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Differences in Cytochrome P450-Mediated Pharmacokinetics Between Chinese and Caucasian Populations Predicted by Mechanistic Physiologically Based Pharmacokinetic Modelling

Clinical Pharmacokinetics ◽

10.1007/s40262-013-0089-y ◽

2013 ◽

Vol 52 (12) ◽

pp. 1085-1100 ◽

Author(s):

Zoe E. Barter ◽

Geoffrey T. Tucker ◽

Karen Rowland-Yeo

Keyword(s):

Cytochrome P450 ◽

Pharmacokinetic Modelling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based Pharmacokinetic Modelling ◽

Physiologically Based

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Physiologically based pharmacokinetic modelling to support the clinical management of drug‐drug interactions with bictegravir

Clinical Pharmacology & Therapeutics ◽

10.1002/cpt.2221 ◽

2021 ◽

Author(s):

Felix Stader ◽

Manuel Battegay ◽

Catia Marzolini

Keyword(s):

Drug Interactions ◽

Clinical Management ◽

Pharmacokinetic Modelling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based Pharmacokinetic Modelling ◽

Physiologically Based

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Prediction of olanzapine exposure in individual patients using physiologically based pharmacokinetic modelling and simulation

British Journal of Clinical Pharmacology ◽

10.1111/bcp.13480 ◽

2018 ◽

Vol 84 (3) ◽

pp. 462-476 ◽

Author(s):

Thomas M. Polasek ◽

Geoffrey T. Tucker ◽

Michael J. Sorich ◽

Michael D. Wiese ◽

Titus Mohan ◽

...

Keyword(s):

Modelling And Simulation ◽

Pharmacokinetic Modelling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based Pharmacokinetic Modelling ◽

Physiologically Based

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Physiologically based pharmacokinetic modelling: a sub-compartmentalized model of tissue distribution

Journal of Pharmacokinetics and Pharmacodynamics ◽

10.1007/s10928-007-9071-3 ◽

2007 ◽

Vol 34 (6) ◽

pp. 789-806 ◽

Author(s):

Max von Kleist ◽

Wilhelm Huisinga

Keyword(s):

Tissue Distribution ◽

Pharmacokinetic Modelling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based Pharmacokinetic Modelling ◽

Physiologically Based

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Physiologically‐based pharmacokinetic modelling to predict oprozomib CYP3A drug–drug interaction potential in patients with advanced malignancies

British Journal of Clinical Pharmacology ◽

10.1111/bcp.13817 ◽

2018 ◽

Vol 85 (3) ◽

pp. 530-539 ◽

Author(s):

Ying Ou ◽

Yang Xu ◽

Lia Gore ◽

R. Donald Harvey ◽

Alain Mita ◽

...

Keyword(s):

Drug Interaction ◽

Interaction Potential ◽

Pharmacokinetic Modelling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based Pharmacokinetic Modelling ◽

Advanced Malignancies ◽

Physiologically Based ◽

Drug Drug Interaction

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Development of a Korean‐specific virtual population for physiologically based pharmacokinetic modelling and simulation

Biopharmaceutics & Drug Disposition ◽

10.1002/bdd.2178 ◽

2019 ◽

Vol 40 (3-4) ◽

pp. 135-150 ◽

Author(s):

Yun Kim ◽

Oliver Hatley ◽

Su‐jin Rhee ◽

Sojeong Yi ◽

Hyun A. Lee ◽

...

Keyword(s):

Modelling And Simulation ◽

Pharmacokinetic Modelling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based Pharmacokinetic Modelling ◽

Virtual Population ◽

Physiologically Based

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