physiologically based pharmacokinetic modelling Recently Published Documents

Physiologically Based ◽

Drug Drug Interaction ◽

Modelling Approach

Correction to: Physiologically based pharmacokinetic modelling to predict the clinical effect of CYP3A inhibitors/inducers on esaxerenone pharmacokinetics in healthy subjects and subjects with hepatic impairment

European Journal of Clinical Pharmacology ◽

10.1007/s00228-021-03211-z ◽

2021 ◽

Author(s):

Akiko Watanabe ◽

Tomoko Ishizuka ◽

Makiko Yamada ◽

Yoshiyuki Igawa ◽

Takako Shimizu ◽

...

Keyword(s):

Hepatic Impairment ◽

Healthy Subjects ◽

Clinical Effect ◽

Physiologically based pharmacokinetic modelling to investigate the impact of the cytokine storm on CYP3A drug pharmacokinetics in COVID‐19 patients

Clinical Pharmacology & Therapeutics ◽

10.1002/cpt.2402 ◽

2021 ◽

Author(s):

Felix Stader ◽

Manuel Battegay ◽

Parham Sendi ◽

Catia Marzolini

Keyword(s):

Cytokine Storm ◽

Physiologically Based ◽

The Impact ◽

Drug Pharmacokinetics

Physiologically-Based Pharmacokinetic Modelling of Entrectinib Parent and Active Metabolite to Support Regulatory Decision-Making

European Journal of Drug Metabolism and Pharmacokinetics ◽

10.1007/s13318-021-00714-z ◽

2021 ◽

Author(s):

Nassim Djebli ◽

Vincent Buchheit ◽

Neil Parrott ◽

Elena Guerini ◽

Yumi Cleary ◽

...

Keyword(s):

Decision Making ◽

Active Metabolite ◽

Regulatory Decision ◽

Physiologically Based Pharmacokinetic Modelling of Inhaled Nemiralisib: Mechanistic Components for Pulmonary Absorption, Systemic Distribution, and Oral Absorption

Clinical Pharmacokinetics ◽

10.1007/s40262-021-01066-2 ◽

2021 ◽

Author(s):

Neil A. Miller ◽

Rebecca H. Graves ◽

Chris D. Edwards ◽

Augustin Amour ◽

Ed Taylor ◽

...

Keyword(s):

Oral Absorption ◽

Pulmonary Absorption ◽

Systemic Distribution ◽

Physiologically based pharmacokinetic modelling of acetaminophen in preterm neonates ‐ the impact of metabolising enzyme ontogeny and reduced cardiac output

Biopharmaceutics & Drug Disposition ◽

10.1002/bdd.2301 ◽

2021 ◽

Author(s):

Olusola Olafuyi ◽

Mohammad Abbasi ◽

Karel Allegaert

Keyword(s):

Cardiac Output ◽

Preterm Neonates ◽

Physiologically Based ◽

The Impact

Crosstalk of physiological pH and chemical pKa under the umbrella of physiologically based pharmacokinetic modelling of drug absorption, distribution, metabolism, excretion and toxicity

Expert Opinion on Drug Metabolism & Toxicology ◽

10.1080/17425255.2021.1951223 ◽

2021 ◽

Author(s):

Lu Gaohua ◽

Xiusheng Miao ◽

Liu Dou

Keyword(s):

Drug Absorption ◽

Physiologically based pharmacokinetic modelling of treprostinil after intravenous injection and extended‐release oral tablet administration in healthy volunteers: An extrapolation to other patient populations including patients with hepatic impairment

British Journal of Clinical Pharmacology ◽

10.1111/bcp.14966 ◽

2021 ◽

Author(s):

Xuemei Wu ◽

Xiaohan Zhang ◽

Ruichao Xu ◽

Imam Hussain Shaik ◽

Raman Venkataramanan

Keyword(s):

Healthy Volunteers ◽

Intravenous Injection ◽

Hepatic Impairment ◽

Extended Release ◽

Oral Tablet ◽

Personalise vitamin D 3 using physiologically based pharmacokinetic modelling

CPT Pharmacometrics & Systems Pharmacology ◽

10.1002/psp4.12640 ◽

2021 ◽

Author(s):

Zhonghui Huang ◽

Tao You

Keyword(s):

Vitamin D ◽

Physiologically Based ◽

Vitamin D 3

Physiologically based pharmacokinetic modelling to support the clinical management of drug‐drug interactions with bictegravir

Clinical Pharmacology & Therapeutics ◽

10.1002/cpt.2221 ◽

2021 ◽

Author(s):

Felix Stader ◽

Manuel Battegay ◽

Catia Marzolini

Keyword(s):

Drug Interactions ◽

Clinical Management ◽