Significance of Fetal Aberrant Right Subclavian Artery and Comparison with Other Second Trimester Markers for Down Syndrome Screening

2016 ◽  
Vol 3 (4) ◽  
pp. 159-165 ◽  
Author(s):  
Seneesh Kumar Vikraman ◽  
Vipin Chandra ◽  
Bijoy Balakrishnan ◽  
Meenu Batra ◽  
P. S. Sreeja ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Subclavian Artery ◽  
Aberrant Right Subclavian Artery ◽  
Second Trimester ◽  
Down Syndrome Screening

Aberrant right subclavian artery: incidence and correlation with other markers of Down syndrome in second-trimester fetuses

2012 ◽  
Vol 39 (2) ◽  
pp. 191-195 ◽  
Author(s):  
D. Paladini ◽  
G. Sglavo ◽  
G. Pastore ◽  
A. Masucci ◽  
M. R. D'Armiento ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Subclavian Artery ◽  
Aberrant Right Subclavian Artery ◽  
Second Trimester

Isolated aberrant right subclavian artery at 14-16 weeks of gestation and Down syndrome

2017 ◽  
Vol 46 (1) ◽  
pp. 62-63
Author(s):  
Ron Beloosesky ◽  
Alon Shrim ◽  
Maya Steinberg ◽  
Nizar Khatib ◽  
Moshe Bronshtein
Keyword(s):  
Down Syndrome ◽  
Subclavian Artery ◽  
Aberrant Right Subclavian Artery

scholarly journals Hyperglycosylated Human Chorionic Gonadotropin (Invasive Trophoblast Antigen) Immunoassay: A New Basis for Gestational Down Syndrome Screening

1999 ◽  
Vol 45 (12) ◽  
pp. 2109-2119 ◽  
Author(s):  
Laurence A Cole ◽  
Shohreh Shahabi ◽  
Utku A Oz ◽  
Ray O Bahado-Singh ◽  
Maurice J Mahoney
Keyword(s):  
Down Syndrome ◽  
False Positive ◽  
False Positive Rate ◽  
Normal Karyotype ◽  
Screen Test ◽  
Β Subunit ◽  
Second Trimester ◽  
Marker Test ◽  
Positive Rate ◽  
Down Syndrome Screening

Abstract Background: Serum human chorionic gonadotropin (hCG) and hCG free β-subunit tests are used in combination with unconjugated estriol and α-fetoprotein in the triple screen test, and with the addition of inhibin-A in the quadruple marker test for detecting Down syndrome in the second trimester of pregnancy. These tests have a limited detection rate for Down syndrome: ∼40% for hCG or free β-subunit alone, ∼60% for the triple screen test, and ∼70% for the quadruple marker test, all at 5%, or a relatively high, false-positive rate. New tests are needed with higher detection and lower false rates. Hyperglycosylated hCG (also known as invasive trophoblast antigen or ITA) is a new test. It specifically detects a unique oligosaccharide variant of hCG associated with Down syndrome pregnancies. We evaluated this new Down syndrome-directed test in prenatal diagnosis. Methods: Hyperglycosylated hCG was measured in urine samples from women undergoing amniocentesis for advanced maternal age concerns at 14–22 weeks of gestation, 1448 with normal karyotype and 39 with Down syndrome fetuses. Results: The median hyperglycosylated hCG value was 9.5-fold higher in Down syndrome cases (9.5 multiples of the normal karyotype median). The single test detected 80% of Down syndrome cases at a 5% false-positive rate. Urine hyperglycosylated hCG was combined with urine β-core fragment (urine breakdown product of serum hCG free β-subunit), serum α-fetoprotein, and maternal age-related risk. This urine-serum combination detected 96% of Down syndrome cases at a 5% false-positive rate, 94% of cases at a 3% false-positive rate, and 71% of cases at a 1% false-positive rate. These detection rates exceed those of any previously reported combination of biochemical markers. Conclusions: Hyperglycosylated hCG is a new base marker for Down syndrome screening in the second trimester of pregnancy. The measurement of hyperglycosylated hCG can fundamentally improve the performance of Down syndrome screening protocols.

Combining first and second trimester markers for Down syndrome screening: Think twice

2008 ◽  
Vol 48 (5) ◽  
pp. 492-500 ◽  
Author(s):  
Robert COCCIOLONE ◽  
Kate BRAMELD ◽  
Peter O’LEARY ◽  
Eric HAAN ◽  
Peter MULLER ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Second Trimester ◽  
Down Syndrome Screening

scholarly journals 350: Observed:expected ratios: assessment of nasal bone length for second-trimester Down syndrome screening in a user-friendly fashion

2011 ◽  
Vol 204 (1) ◽  
pp. S143
Author(s):  
Jennifer McNamara ◽  
Harish Sehdev ◽  
Alison Cahill ◽  
Linda Odibo ◽  
George Macones ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Nasal Bone ◽  
Second Trimester ◽  
Bone Length ◽  
Nasal Bone Length ◽  
User Friendly ◽  
Down Syndrome Screening

OC101: Fetal aberrant right subclavian artery in normal fetuses and in Down syndrome

2007 ◽  
Vol 30 (4) ◽  
pp. 398-398 ◽  
Author(s):  
Y. Zalel ◽  
R. Achiron ◽  
S. Yagel ◽  
Z. Kivilevitch
Keyword(s):  
Down Syndrome ◽  
Subclavian Artery ◽  
Aberrant Right Subclavian Artery

Comparison of the efficiency of second-trimester nasal bone hypoplasia and increased nuchal fold in Down syndrome screening

2008 ◽  
Vol 199 (3) ◽  
pp. 281.e1-281.e5 ◽  
Author(s):  
Anthony O. Odibo ◽  
Harish M. Sehdev ◽  
Sabrina Gerkowicz ◽  
David M. Stamilio ◽  
George A. Macones
Keyword(s):  
Down Syndrome ◽  
Nasal Bone ◽  
Second Trimester ◽  
Down Syndrome Screening

Defining nasal bone (NB) hypoplasia in second-trimester down syndrome screening: Does the use of multiples of the median (MOM) improve screening efficiency?

2006 ◽  
Vol 195 (6) ◽  
pp. S168
Author(s):  
Anthony Odibo ◽  
Harish M. Sehdev ◽  
David Stamilio ◽  
Alison Cahill ◽  
Linda Dunn ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Nasal Bone ◽  
Second Trimester ◽  
Screening Efficiency ◽  
Down Syndrome Screening
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