The interesting picture: simultaneous occurrence of myeloma cast nephropathy, light chain deposition disease and light chain proximal tubulopathy in a patient with multiple myeloma

2020 ◽  
Vol 33 (4) ◽  
pp. 649-651
Author(s):  
Zi-Shan Lin ◽  
Xiao-Juan Yu ◽  
Su-Xia Wang ◽  
Fu-De Zhou ◽  
Ming-Hui Zhao
Keyword(s):  
Multiple Myeloma ◽  
Light Chain ◽  
Simultaneous Occurrence ◽  
Light Chain Deposition Disease ◽  
Cast Nephropathy ◽  
Deposition Disease ◽  
Myeloma Cast Nephropathy ◽  
Proximal Tubulopathy ◽  
Light Chain Proximal Tubulopathy ◽  
Light Chain Deposition

The concurrence of light-chain deposition disease, AL-amyloidosis, and cast nephropathy in a patient with multiple myeloma

2015 ◽  
Vol 87 (6) ◽  
pp. 98
Author(s):  
I. G. Rekhtina ◽  
E. V. Zakharova ◽  
E. S. Stolyarevich ◽  
M. N. Sinitsina ◽  
E. N. Denisova
Keyword(s):  
Multiple Myeloma ◽  
Light Chain ◽  
Al Amyloidosis ◽  
Light Chain Deposition Disease ◽  
Cast Nephropathy ◽  
Deposition Disease ◽  
Light Chain Deposition

Clinicopathological features and outcomes of coexistent light chain cast nephropathy and light chain deposition disease in patients with newly diagnosed multiple myeloma

2021 ◽  
pp. jclinpath-2021-207449
Author(s):  
Zi-Shan Lin ◽  
Xu Zhang ◽  
Dan-Yang Li ◽  
Xiao-Juan Yu ◽  
Ai-Bo Qin ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Overall Survival ◽  
Light Chain ◽  
Renal Outcome ◽  
Newly Diagnosed ◽  
Renal Survival ◽  
Light Chain Deposition Disease ◽  
Cast Nephropathy ◽  
Deposition Disease ◽  
Light Chain Deposition

AimsA varying proportion of patients with multiple myeloma suffer from more than one type of kidney disease simultaneously, of which the most common pattern is coexistent light chain cast nephropathy and light chain deposition disease (LCCN+LCDD). We investigated clinicopathological characteristics and outcomes of LCCN+LCDD in comparison with pure LCCN and pure LCDD.MethodsWe retrospectively analysed 45 newly diagnosed multiple myeloma patients with pure LCCN (n=26), LCCN +LCDD (n=9) and pure LCDD (n=10) between 2000 and 2019 at Peking University First Hospital.ResultsPathologically, patients with LCCN+LCDD were more likely to have λ light chain isotype and presented atypical features of LCDD including less nodular glomerulosclerosis and less deposit distribution than patients with pure LCDD. In clinical characteristics, patients with LCCN +LCDD and patients with pure LCCN shared similar features. The death-censored renal survival in patients with LCCN +LCDD was similar to patients with pure LCCN but worse than patients with pure LCDD, but the overall survival was much better than patients with LCCN alone and similar to patients with pure LCDD. For patients with pure LCCN, the independent predictor of death-censored renal survival was lactate dehydrogenase, and the independent predictors of overall survival were the mean number of casts and serum albumin.ConclusionsPatients with LCCN+LCDD had similar renal outcome compared with patients with pure LCCN but the overall survival is much better. Thus, for patients with LCCN, especially those with λ restriction, pathologists should carefully evaluate the kidney specimens to exclude the possibility of combined LCDD.

Clinical and prognostic differences among patients with light chain deposition disease, myeloma cast nephropathy and both

2015 ◽  
Vol 56 (12) ◽  
pp. 3357-3364 ◽  
Author(s):  
Ladan Zand ◽  
Samih H. Nasr ◽  
Morie A Gertz ◽  
Angela Dispenzieri ◽  
Martha Q. Lacy ◽  
...  
Keyword(s):  
Light Chain ◽  
Light Chain Deposition Disease ◽  
Cast Nephropathy ◽  
Deposition Disease ◽  
Myeloma Cast Nephropathy ◽  
Light Chain Deposition

Recovery from LCDD-associated Severe Liver Cholestasis: a Case Report and Literature Review

2016 ◽  
Vol 25 (1) ◽  
pp. 99-103 ◽  
Author(s):  
Benoit Brilland ◽  
Johnny Sayegh ◽  
Anne Croue ◽  
Frank Bridoux ◽  
Jean-François Subra ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Light Chain ◽  
Intrahepatic Cholestasis ◽  
Relevant Literature ◽  
Gamma Glutamyl Transferase ◽  
Light Chain Deposition Disease ◽  
Deposition Disease ◽  
Uncommon Presentation ◽  
Light Chain Deposition ◽  
Glutamyl Transferase

Light chain deposition disease (LCDD) is a rare multisystemic disorder associated with plasma cell proliferation. It mainly affects the kidney, but liver and heart involvement may occur, sometimes mimicking the picture of systemic amyloidosis. Liver disease in LCDD is usually asymptomatic and exceptionally manifests with severe cholestatic hepatitis. We report the case of a 66-year-old female with κ-LCDD and cast nephropathy in the setting of symptomatic multiple myeloma who, after a first cycle of bortezomib-dexamethasone chemotherapy, developed severe and rapidly worsening intrahepatic cholestasis secondary to liver κ-light chain deposition. Intrahepatic cholestasis was attributed to LCDD on the basis of the liver histology and exclusion of possible diagnoses. Chemotherapy was maintained and resulted in progressive resolution of cholestasis. We report here an uncommon presentation of LCDD, with prominent liver involvement that fully recovered with bortezomib-based chemotherapy, and briefly review the relevant literature. Abbreviations: AKI: Acute kidney injury; ALP: alkaline phosphatase; ALT: alanine aminotransferase; AST: aspartate aminotransferase; CMV: Cytomegalovirus; EBV: Epstein–Barr virus; GGT: gamma-glutamyl transferase; HSV: Herpes simplex virus; LC: light chain; LCDD: Light chain deposition disease; MIDD: Monoclonal immunoglobulin deposition disease; MM: Multiple myeloma.

scholarly journals Clinical characteristics and prognostic factors in multiple myeloma patients with light chain deposition disease

2017 ◽  
Vol 92 (8) ◽  
pp. 739-745 ◽  
Author(s):  
Meera Mohan ◽  
Amy Buros ◽  
Pankaj Mathur ◽  
Neriman Gokden ◽  
Manisha Singh ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Prognostic Factors ◽  
Light Chain ◽  
Clinical Characteristics ◽  
Light Chain Deposition Disease ◽  
Deposition Disease ◽  
Light Chain Deposition
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