scholarly journals Stem Cell Therapies for the Resolution of Radiation Injury to the Brain

2017 ◽  
Vol 3 (4) ◽  
pp. 342-347 ◽  
Author(s):  
Sarah M. Smith ◽  
Charles L. Limoli
Keyword(s):  
Stem Cell ◽  
Radiation Injury ◽  
Stem Cell Therapies ◽  
Cell Therapies ◽  
The Brain

Stem cell therapies for malignant glioma

2005 ◽  
Vol 19 (3) ◽  
pp. 1-11 ◽  
Author(s):  
Moneeb Ehtesham ◽  
Charles B. Stevenson ◽  
Reid C. Thompson
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Malignant Glioma ◽  
Treatment Strategies ◽  
Therapeutic Benefit ◽  
Therapeutic Modality ◽  
Clinical Implementation ◽  
Stem Cell Therapies ◽  
Cell Therapies ◽  
The Brain

The prognosis for patients with malignant glioma, which is the most common primary intracranial neoplasm, remains dismal despite significant progress in neurooncological therapies and technology. This is largely due to the inability of current treatment strategies to address the highly invasive nature of this disease. Malignant glial cells often disseminate throughout the brain, making it exceedingly difficult to target and treat all intracranial neoplastic foci, with the result that tumor recurrence is inevitable despite aggressive surgery and adjuvant radiotherapy and/or chemotherapy. The use of neural stem cells (NSCs) as delivery vehicles for tumor-toxic molecules represents the first experimental strategy aimed specifically at targeting disseminated tumor pockets. Investigators have demonstrated that NSCs possess robust tropism for infiltrating tumor cells, and that they can be used to deliver therapeutic agents directly to tumor satellites, with significant therapeutic benefit. With the aim of developing these findings into a clinically viable technology that would not be hindered by ethical and tissue rejection–related concerns, the use of adult tissue–derived stem cells has recently been explored. These technologies represent important progress in the development of a treatment strategy that can specifically target disseminated neoplastic pockets within the brain. Despite encouraging results in preclinical models, however, there are significant impediments that must be overcome prior to clinical implementation of this strategy. Key among these are an inadequate understanding of the specific tropic mechanisms that govern NSC migration toward invasive tumor, and the need to refine the processes used to generate tumor-tropic stem cells from adult tissues so that this can be accomplished in a clinically practicable fashion. Despite these limitations, the use of stem cell therapies for brain tumors holds significant promise and may emerge as an important therapeutic modality for patients with malignant glioma.

Sternal bone marrow is a suitable autologous cell source for cardiac stem cell therapies

2014 ◽  
Vol 62 (S 01) ◽  
Author(s):  
M. Arar ◽  
A. Rotärmel ◽  
A.-K. Knoefel ◽  
H. Baraki ◽  
I. Kutschka ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Cardiac Stem Cell ◽  
Stem Cell Therapies ◽  
Cell Therapies ◽  
Autologous Cell ◽  
Cell Source

Endometrial Regeneration in Asherman's Syndrome: Clinical and Translational evidence of Stem Cell Therapies

2019 ◽  
Vol 14 (6) ◽  
pp. 454-459
Author(s):  
Xuejing Hou ◽  
Ying Liu ◽  
Isabelle Streuli ◽  
Patrick Dällenbach ◽  
Jean Dubuisson ◽  
...  
Keyword(s):  
Stem Cell ◽  
Molecular Mechanisms ◽  
Uterine Cavity ◽  
Stem Cell Therapies ◽  
Intrauterine Adhesions ◽  
Asherman’S Syndrome ◽  
Cell Therapies ◽  
Fibrotic Process ◽  
Physical Barriers

Asherman’s Syndrome or Intrauterine adhesions is an acquired uterine condition where fibrous scarring forms within the uterine cavity, resulting in reduced menstrual flow, pelvic pain and infertility. Until recently, the molecular mechanisms leading to the formation of fibrosis were poorly understood, and the treatment of Asherman’s syndrome has largely focused on hysteroscopic resection of adhesions, hormonal therapy, and physical barriers. Numerous studies have begun exploring the molecular mechanisms behind the fibrotic process underlying Asherman’s Syndrome as well as the role of stem cells in the regeneration of the endometrium as a treatment modality. The present review offers a summary of available stem cell-based regeneration studies, as well as highlighting current gaps in research.

Stem Cell Therapies

2016 ◽  
Vol 5 (2) ◽  
pp. 145-151
Author(s):  
Ana Muñoz ◽  
Víctor Galvez ◽  
María Camarasa
Keyword(s):  
Stem Cell ◽  
Stem Cell Therapies ◽  
Cell Therapies

Public Opinion and Expectations of Stem Cell Therapies in Orthopaedics*

2021 ◽  
Author(s):  
Richard N. Puzzitiello ◽  
Jeremy Dubin ◽  
Mariano E. Menendez ◽  
Michael A. Moverman ◽  
Nicholas R. Pagani ◽  
...  
Keyword(s):  
Stem Cell ◽  
Public Opinion ◽  
Stem Cell Therapies ◽  
Cell Therapies

Equine Models for the Investigation of Mesenchymal Stem Cell Therapies in Orthopaedic Disease

2017 ◽  
Vol 25 (1) ◽  
pp. 41-49 ◽  
Author(s):  
Aimée C. Colbath ◽  
David D. Frisbie ◽  
Steven W. Dow ◽  
John D. Kisiday ◽  
C. Wayne McIlwraith ◽  
...  
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Stem Cell Therapies ◽  
Cell Therapies

scholarly journals Stem cell therapies for systemic sclerosis

2014 ◽  
Vol 168 (3) ◽  
pp. 328-337 ◽  
Author(s):  
Paola Cipriani ◽  
Piero Ruscitti ◽  
Roberto Giacomelli
Keyword(s):  
Stem Cell ◽  
Systemic Sclerosis ◽  
Stem Cell Therapies ◽  
Cell Therapies

Urine Is a Highly Cytotoxic Agent: Does It Influence Stem Cell Therapies in Urology?

2012 ◽  
Vol 44 (5) ◽  
pp. 1439-1441 ◽  
Author(s):  
J. Adamowicz ◽  
T. Kloskowski ◽  
J. Tworkiewicz ◽  
M. Pokrywczyńska ◽  
T. Drewa
Keyword(s):  
Stem Cell ◽  
Cytotoxic Agent ◽  
Stem Cell Therapies ◽  
Cell Therapies
Sign in / Sign up

Export Citation Format

Share Document