Considering the characteristics of high-speed railway settlement requirement, i.e. high precision and strict control after construction, the subgrade settlement of the Wuhan-Guangzhou high-speed rail on the red clay area is calculated by ES method, e-lgp method, triaxial stress method, secant modulus method and field test method. In this essay, the accuracy of various calculation methods has been compared and corrected with the values from loading test. In this process, correction coefficients for various calculation methods have been obtained.