Identifying key prescribing cascades in older people (iKASCADE): a transnational initiative on drug safety through a sex and gender lens—rationale and design

Abstract Background Integrating a sex and gender lens is increasingly recognized as important in health research studies. Past failures to adequately consider sex in drug development, for example, led to medications that were metabolized differently, proved harmful, or ineffective, for females. Including both males and females in study populations is important but not sufficient; health, access to healthcare, and treatment provided are also influenced by gender, the socially mediated roles, responsibilities, and behaviors of boys, girls, women and men. Despite understanding the relevance of sex and gender to health research, integrating this lens into study designs can still be challenging. Identified here, are nine opportunities to address sex and gender and thereby strengthen research proposals. Methods Ontario investigators were invited to submit a draft of their health research proposal to the Sex and Gender Research Support Service (SGRSS) at Women’s College Hospital in Toronto, Ontario. The service works to build capacity on the integration of sex, gender, and other identity factors, in health research. Using the SAGER Guidelines and the METRICS for the Study of Sex and Gender in Human Participants as guides, proposals were reviewed to enhance their sex and gender considerations. Content analysis of the feedback provided these investigators was subsequently completed. Results Nearly 100 hundred study proposals were reviewed and investigators provided with suggestions on how to enhance their proposal. Analyzing the feedback provided across the reviewed studies revealed commonly overlooked opportunities to elevate consideration of sex and gender. These were organized into nine suggestions to mirror the sections of a research proposal. Conclusion Health researchers are often challenged on how to integrate a sex and gender lens into their work. Reviews completed across a range of health research studies show there are several commonly overlooked opportunities to do better in this regard. Nine ways to improve the integration of a sex and gender lens in health research proposals have been identified.

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Equity in military and Veteran research: Why it is essential to integrate an intersectional sex and gender lens

Journal of Military Veteran and Family Health ◽

10.3138/jmvfh-2021-0016 ◽

2021 ◽

pp. e20210016

Author(s):

Maya Eichler

Keyword(s):

Health Research ◽

Family Health ◽

Veteran Health ◽

Sex And Gender ◽

Gender Diverse ◽

Military Members ◽

Long Time ◽

And Gender ◽

The Military ◽

Gender Lens

Lay Summary For a long time, it has been assumed that to study military members and Veterans means to study men. Further com-pounding the problem, military and Veteran health research has historically neglected sex and gender issues. This has resulted in systemic biases and gaps in military and Veteran health research that perpetuate existing inequities. How-ever, as this Perspectives piece argues, equity should be a key objective of military and Veteran research. Equity means that the diverse needs of all in the military and Veteran population are considered and addressed. Equity helps ensure fairness and justice in the military and Veteran sector. One of the best ways to advance the goal of equity in research and beyond is to apply an intersectional sex and gender lens. This means, for example, to make visible women’s specific experiences and health outcomes, as well as those of sub-groups of women, men, or gender-diverse military members and Veterans. The author provides tools and considerations for the application of an intersectional sex and gender lens in military, Veteran, and family health research.

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The Opioid Epidemic: Overcoming Challenges by Using a Sex and Gender Lens

Clinical Therapeutics ◽

10.1016/j.clinthera.2018.01.007 ◽

2018 ◽

Vol 40 (2) ◽

pp. 188-189 ◽

Cited By ~ 2

Author(s):

Alyson J. McGregor

Keyword(s):

Opioid Epidemic ◽

Sex And Gender ◽

And Gender ◽

Gender Lens

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Viewing the COVID-19 Pandemic Through a Sex and Gender Lens

Journal of Women s Health ◽

10.1089/jwh.2020.8847 ◽

2020 ◽

Author(s):

Danielle A. D'Annibale ◽

Jennifer L. Purks ◽

Janvi Huria ◽

Akshara Ramasamy ◽

Suhani Akhouri ◽

...

Keyword(s):

Sex And Gender ◽

And Gender ◽

Gender Lens

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Sustainability Through a Gender Lens: The Extent to Which Research on UN Sustainable Development Goals (SDGs) Includes Sex and Gender Consideration

SSRN Electronic Journal ◽

10.2139/ssrn.3689205 ◽

2020 ◽

Author(s):

Rachel Herbert ◽

Holly Falk-Krzesinski ◽

Andrew Plume

Keyword(s):

Sustainable Development ◽

Sustainable Development Goals ◽

Sex And Gender ◽

Development Goals ◽

And Gender ◽

Gender Lens

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Sex and Gender in Family Business Succession Research: A Review and Forward Agenda From a Social Construction Perspective

Family Business Review ◽

10.1177/0894486517715390 ◽

2017 ◽

Vol 30 (3) ◽

pp. 219-241 ◽

Cited By ~ 30

Author(s):

Teresa Nelson ◽

Christina Constantinidis

Keyword(s):

Family Business ◽

Sex And Gender ◽

Expectation States ◽

Socially Constructed ◽

Expectation States Theory ◽

Points Of View ◽

And Gender ◽

Business Succession ◽

Family Business Succession ◽

Gender Lens

This article focuses on how family business succession research has engaged and may be further enriched by application of a gender lens as socially constructed. We analyze the succession literature developing a gender terms vocabulary and five themes of historical engagement. Finding a lack of theoretical grounding, we apply the construct of gender, through expectation states theory, revising the Sharma and Irving model of successor commitment to examine how a socially constructed view of gender shifts and opens up points of view. We then present a forward looking agenda to motivate future scholarship.

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Roundtable Discussion on COVID-19 Through a Sex and Gender Lens

Gender and the Genome ◽

10.1177/2470289720957015 ◽

2020 ◽

Vol 4 ◽

pp. 247028972095701

Author(s):

Marianne J. Legato ◽

Wendy L. Bennett ◽

Sabra Klein ◽

Jeanne S. Sheffield ◽

Rosemary Morgan ◽

...

Keyword(s):

Well Being ◽

Sex And Gender ◽

Care Providers ◽

Roundtable Discussion ◽

Global Pandemic ◽

Johns Hopkins University ◽

The Social ◽

And Gender ◽

The Impact ◽

Gender Lens

Although the full and lasting impact of the coronavirus disease 2019 (COVID-19) outbreak is yet to be determined, there is evidence that sex and gender play a significant role in determining patient outcomes across the globe. This roundtable discussion is a transcript of a seminar held by several representatives from Johns Hopkins University on the impact of the global pandemic on women’s health and well-being. They reported on the various pathophysiological aspects of the disease, as well as the social and financial consequences of this global pandemic. Looking at COVID-19 through a sex and gender lens highlights the vulnerabilities and inequalities of people of different genders, races, and socioeconomic conditions, and how care providers can better respond to those differences.

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