Nature of spontaneously arising single base substitutions in normal cells

2021 ◽  
Author(s):  
Shunichi Takeda ◽  
Yang Luan
Keyword(s):  
Normal Cells ◽  
Single Base ◽  
Base Substitutions

scholarly journals Inter- and intraspecific variation of chloroplast mini- and microsatellites DNA in the four closed related Acacia species

2015 ◽  
Vol 19 (1) ◽  
pp. 1
Author(s):  
AYPBC Widyatmoko ◽  
Susumu Shiraishi
Keyword(s):  
Intraspecific Variation ◽  
Sequence Information ◽  
Single Base ◽  
Coding Regions ◽  
Acacia Species ◽  
Base Substitutions ◽  
Microsatellites Dna

Mini- and microsatellites of four Acacia species, A. aulacocarpa, A. auriculiformis, A. crassicarpa and A.mangium were investigated on four non-coding regions of cpDNA, the intron of trnL, and the intergenicspacers of trnL - trnP, trnD - trnY, and trnP – trnW. Nine single base substitutions and six informative miniandmicrosatellites were detected in the the four cpDNA non-coding regions. Based on the substitutionsand mini- and microsatellites, ten cpDNA haplotypes (A - J) could be distinguished. Acacia auriculiformispossessed fi ve haplotypes, A. aulacocarpa, four haplotypes, and A. crassicarpa, three haplotypes. All samplesof A. mangium possessed the same haplotype. Mini- and microsatellites recognized in this study can beused for species identifi cation of the four Acacia species. The ten haplotypes could divided the four speciesinto 2 groups, A. aulacocarpa-A.crassicarpa group and A. auriculiformis-A. mangium group. By developing thePCR-based markers based on the sequence information, many experiments can be carried out for the Acaciaimprovement programs.

Discrimination of Single Base Substitutions in a DNA Strand Immobilized in a Biological Nanopore

ACS Nano ◽  
2009 ◽  
Vol 3 (9) ◽  
pp. 2533-2538 ◽  
Author(s):  
Robert F. Purnell ◽  
Jacob J. Schmidt
Keyword(s):  
Single Base ◽  
Base Substitutions ◽  
Dna Strand

scholarly journals Analysis of somatic mutations in kappa transgenes.

1990 ◽  
Vol 172 (1) ◽  
pp. 131-137 ◽  
Author(s):  
J Hackett ◽  
B J Rogerson ◽  
R L O'Brien ◽  
U Storb
Keyword(s):  
Nuclear Matrix ◽  
Somatic Mutations ◽  
Mutation Process ◽  
Single Base ◽  
Base Substitutions ◽  
Flanking Sequences ◽  
V Region

We have examined the nature and localization of somatic mutations in three kappa transgenes cloned from IgG-secreting hybridomas. All of the mutations identified were single base substitutions. Mutations were localized to the variable (V) region and its flanking sequences. In every case, the nuclear matrix association region, kappa enhancer, and C gene were spared. These data indicate that the rearranged kappa gene contains the necessary sequences for targeting of the mutation process, and suggest that the observed localization of mutations to the V region reflects the inherent specificity of this mutation process.

scholarly journals Development of high-level ceftazidime resistance via single-base substitutions of blaCTX-M-3 in hyper-mutable Escherichia coli

2006 ◽  
Vol 12 (8) ◽  
pp. 803-806 ◽  
Author(s):  
E. Karisik ◽  
M.J. Ellington ◽  
R. Pike ◽  
D.M. Livermore ◽  
N. Woodford
Keyword(s):  
Escherichia Coli ◽  
Single Base ◽  
Base Substitutions ◽  
High Level

scholarly journals Introduction of Single Base Substitutions at Homologous Chromosomal Sequences by Adeno-associated Virus Vectors

2001 ◽  
Vol 3 (4) ◽  
pp. 526-530 ◽  
Author(s):  
Naoki Inoue ◽  
Rong Dong ◽  
Roli K. Hirata ◽  
David W. Russell
Keyword(s):  
Adeno Associated Virus ◽  
Single Base ◽  
Virus Vectors ◽  
Base Substitutions ◽  
Chromosomal Sequences

Detection of single base substitutions in total genomic DNA

Nature ◽  
1985 ◽  
Vol 313 (6002) ◽  
pp. 495-498 ◽  
Author(s):  
Richard M. Myers ◽  
Nadya Lumelsky ◽  
Leonard S. Lerman ◽  
Tom Maniatis
Keyword(s):  
Genomic Dna ◽  
Single Base ◽  
Base Substitutions

Detection of single base substitutions by ribonuclease cleavage at mismatches in RNA:DNA duplexes

Science ◽  
1985 ◽  
Vol 230 (4731) ◽  
pp. 1242-1246 ◽  
Author(s):  
R. Myers ◽  
Z Larin ◽  
T Maniatis
Keyword(s):  
Single Base ◽  
Base Substitutions
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