Cancer Pain Model, Bone Cancer Pain Model

2012 ◽  
Keyword(s):  
Cancer Pain ◽  
Bone Cancer ◽  
Bone Cancer Pain ◽  
Pain Model

scholarly journals Enhanced GABA ergic synaptic transmission at VLPAG neurons and potent modulation by oxycodone in a bone cancer pain model

2015 ◽  
Vol 172 (8) ◽  
pp. 2148-2164 ◽  
Author(s):  
Keiko Takasu ◽  
Koichi Ogawa ◽  
Atsushi Nakamura ◽  
Tomoe Kanbara ◽  
Hiroko Ono ◽  
...  
Keyword(s):  
Synaptic Transmission ◽  
Cancer Pain ◽  
Bone Cancer ◽  
Bone Cancer Pain ◽  
Pain Model

Bone cancer pain model in mice: evaluation of pain behavior, bone destruction and morphine sensitivity

2004 ◽  
Vol 79 (2) ◽  
pp. 243-251 ◽  
Author(s):  
Hilde Vermeirsch ◽  
Rony M. Nuydens ◽  
Philip L. Salmon ◽  
Theo F. Meert
Keyword(s):  
Cancer Pain ◽  
Bone Destruction ◽  
Bone Cancer ◽  
Pain Behavior ◽  
Bone Cancer Pain ◽  
Pain Model

S186 INVOLVEMENT OF KAPPA AND DELTA OPIOID RECEPTORS IN THE ANTINOCICEPTIVE EFFECT OF CROTALPHINE IN A BONE CANCER PAIN MODEL

2011 ◽  
Vol 5 (1) ◽  
pp. 221
Author(s):  
V.P. Gutierrez ◽  
P. Brigatte ◽  
V.O. Zambelli ◽  
G. Picolo ◽  
J.S.D. Carvalho ◽  
...  
Keyword(s):  
Cancer Pain ◽  
Opioid Receptors ◽  
Antinociceptive Effect ◽  
Bone Cancer ◽  
Bone Cancer Pain ◽  
Pain Model ◽  
Delta Opioid Receptors

scholarly journals Effect of the Norepinephrine Transporter (NET) Inhibition on μ-Opioid Receptor (MOR)-Induced Anti-nociception in a Bone Cancer Pain Model

2014 ◽  
Vol 125 (3) ◽  
pp. 264-273 ◽  
Author(s):  
Hiroko Ono ◽  
Atsushi Nakamura ◽  
Tomoe Kanbara ◽  
Kazuhisa Minami ◽  
Shunji Shinohara ◽  
...  
Keyword(s):  
Cancer Pain ◽  
Opioid Receptor ◽  
Bone Cancer ◽  
Norepinephrine Transporter ◽  
Bone Cancer Pain ◽  
Pain Model ◽  
Μ Opioid Receptor

Cancer Pain Model, Bone Cancer Pain Model

2006 ◽  
pp. 287-289
Author(s):  
Darryl T. Hamamoto ◽  
Donald A. Simone
Keyword(s):  
Cancer Pain ◽  
Bone Cancer ◽  
Bone Cancer Pain ◽  
Pain Model

scholarly journals Differential activation of the μ-opioid receptor by oxycodone and morphine in pain-related brain regions in a bone cancer pain model

2012 ◽  
Vol 168 (2) ◽  
pp. 375-388 ◽  
Author(s):  
Atsushi Nakamura ◽  
Minoru Hasegawa ◽  
Kazuhisa Minami ◽  
Tomoe Kanbara ◽  
Takako Tomii ◽  
...  
Keyword(s):  
Cancer Pain ◽  
Opioid Receptor ◽  
Bone Cancer ◽  
Brain Regions ◽  
Bone Cancer Pain ◽  
Pain Model ◽  
Differential Activation ◽  
Μ Opioid Receptor

scholarly journals Evaluation of Bone Cancer Pain Induced by Different Doses of Walker 256 Mammary Gland Carcinoma Cells

2016 ◽  
Vol 7;19 (7;9) ◽  
pp. E1063-E1077
Author(s):  
Xu
Keyword(s):  
Cancer Pain ◽  
Bone Cancer ◽  
Carcinoma Cells ◽  
Bone Cancer Pain ◽  
Spontaneous Pain ◽  
Pain Model ◽  
Sd Rats ◽  
Walker 256 ◽  
The Right ◽  
Different Doses

Background: Cancer pain is a complex medical syndrome. Understanding its underlying mechanisms relies on the use of animal models which can mimic the human condition. A crucial component of this model is the quantity of tumor cells; however, the exact relationship between the doses of tumor cells on bone cancer pain is yet unknown. Objective: We explored the relationship of different doses of Walker 256 carcinoma cells using a bone cancer pain model in rats, and evaluated its success and stability. Study Design: Experimental animal study using a comparative design. Setting: Experimental Animal Center and Tumor Institute of Traditional Chinese Medicine. Methods: We constructed the bone cancer pain model by implanting Walker 256 carcinoma cells into the right tibia of Sprague-Dawley (SD) rats (150 – 170 g). Spontaneous pain, mechanical threshold, and paw withdrawal latency (PWL) were measured and x-ray, bone mineral density (BMD), histological, interleukin-1 beta (IL-1β) mRNA, carboxyterminal telopeptide of type I collagen (ICTP), and bone alkaline phosphatase (BAP) were analyzed for bone pain model evaluation. Results: The results showed that: (1) the 3 doses (3×105 , 3.5×105 , 4×105 ) of Walker 256 carcinoma cells can induce bone cancer pain from day 7 to day 21 after implantation into the right tibia of SD rats; (2) compared to the control group, 3×105 , 3.5×105 , and 4×105 Walker 256 carcinoma cells produced different pain manifestations, where the 3.5×105 dose of Walker 256 carcinoma cells resulted in the greatest bone cancer pain response; (3) the 3.5×105 dose induced the lowest mortality rate in rats; (4) Walker 256 carcinoma cells (3×105 , 3.5×105 , and 4×105 ) resulted in a significant decrease in the general condition and body weight of rats, where the 3.5×105 and 4×105 doses of carcinoma cells produced a greater effect than 3×105 dose of carcinoma cells; (5) progressive spontaneous pain, PWL, and mechanical threshold were exacerbated by 3.5×105 and 4×105 doses of carcinoma cells; (6) implantation of 3.5×105 and 4×105 doses of carcinoma cells induced progressive bone destruction and decrease in BMD; (7) ICTP and BAP were significantly increased following the implantation of 3.5×105 and 4×105 doses of carcinoma cells; (8) IL-1βmRNA was significantly up-regulated in the spinal cord of rats implanted with 3.5×105 and 4×105 doses of carcinoma cells. Limitations: One limitation of this study was the small sample size; therefore, additional research is needed to provide better validation. Another limitation is the unavailability of small animal Micro computed tomography (CT), which is a more advanced and precise technique in determining bone marrow density than the x-ray imaging system we used. In addition, ethology experiments during late-stage tumor progression can be more objective. Conclusion: This study provides evidence that implantation of 3.5×105 and 4×105 dose of Walker 256 carcinoma cells produced the greatest effects in relation to the bone cancer pain model in SD rats, and 3.5×105 dose induced the lowest mortality rate. Key words: Bone cancer pain model, Walker 256 carcinoma cells, different doses

Spinal PKC activation — Induced neuronal HMGB1 translocation contributes to hyperalgesia in a bone cancer pain model in rats

2018 ◽  
Vol 303 ◽  
pp. 80-94 ◽  
Author(s):  
Kang An ◽  
Hui Rong ◽  
Huadong Ni ◽  
Chunyan Zhu ◽  
Longsheng Xu ◽  
...  
Keyword(s):  
Cancer Pain ◽  
Bone Cancer ◽  
Bone Cancer Pain ◽  
Pain Model ◽  
Pkc Activation
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