Effects of p38 MAPK inhibitor on the rat pain behavior and proinflammatory cytokines in a metastatic bone cancer pain model

2008 ◽  
Vol 7 (3) ◽  
pp. 154-158 ◽  
Author(s):  
Cuiju Tang ◽  
Shiying Yu ◽  
Min Zhang ◽  
Rui Jiang ◽  
Na Li ◽  
...  
Keyword(s):  
Cancer Pain ◽  
P38 Mapk ◽  
Proinflammatory Cytokines ◽  
Bone Cancer ◽  
Pain Behavior ◽  
Bone Cancer Pain ◽  
Pain Model ◽  
P38 Mapk Inhibitor ◽  
Mapk Inhibitor

Bone cancer pain model in mice: evaluation of pain behavior, bone destruction and morphine sensitivity

2004 ◽  
Vol 79 (2) ◽  
pp. 243-251 ◽  
Author(s):  
Hilde Vermeirsch ◽  
Rony M. Nuydens ◽  
Philip L. Salmon ◽  
Theo F. Meert
Keyword(s):  
Cancer Pain ◽  
Bone Destruction ◽  
Bone Cancer ◽  
Pain Behavior ◽  
Bone Cancer Pain ◽  
Pain Model

scholarly journals Enhanced GABA ergic synaptic transmission at VLPAG neurons and potent modulation by oxycodone in a bone cancer pain model

2015 ◽  
Vol 172 (8) ◽  
pp. 2148-2164 ◽  
Author(s):  
Keiko Takasu ◽  
Koichi Ogawa ◽  
Atsushi Nakamura ◽  
Tomoe Kanbara ◽  
Hiroko Ono ◽  
...  
Keyword(s):  
Synaptic Transmission ◽  
Cancer Pain ◽  
Bone Cancer ◽  
Bone Cancer Pain ◽  
Pain Model

S186 INVOLVEMENT OF KAPPA AND DELTA OPIOID RECEPTORS IN THE ANTINOCICEPTIVE EFFECT OF CROTALPHINE IN A BONE CANCER PAIN MODEL

2011 ◽  
Vol 5 (1) ◽  
pp. 221
Author(s):  
V.P. Gutierrez ◽  
P. Brigatte ◽  
V.O. Zambelli ◽  
G. Picolo ◽  
J.S.D. Carvalho ◽  
...  
Keyword(s):  
Cancer Pain ◽  
Opioid Receptors ◽  
Antinociceptive Effect ◽  
Bone Cancer ◽  
Bone Cancer Pain ◽  
Pain Model ◽  
Delta Opioid Receptors

Involvement of CX3CR1 in bone cancer pain through the activation of microglia p38 MAPK pathway in the spinal cord

2012 ◽  
Vol 1465 ◽  
pp. 1-9 ◽  
Author(s):  
Ji-Hua Hu ◽  
Jian-Ping Yang ◽  
Lei Liu ◽  
Cai-Fang Li ◽  
Li-Na Wang ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Cancer Pain ◽  
P38 Mapk ◽  
Mapk Pathway ◽  
Bone Cancer ◽  
Bone Cancer Pain ◽  
P38 Mapk Pathway

scholarly journals Effect of the Norepinephrine Transporter (NET) Inhibition on μ-Opioid Receptor (MOR)-Induced Anti-nociception in a Bone Cancer Pain Model

2014 ◽  
Vol 125 (3) ◽  
pp. 264-273 ◽  
Author(s):  
Hiroko Ono ◽  
Atsushi Nakamura ◽  
Tomoe Kanbara ◽  
Kazuhisa Minami ◽  
Shunji Shinohara ◽  
...  
Keyword(s):  
Cancer Pain ◽  
Opioid Receptor ◽  
Bone Cancer ◽  
Norepinephrine Transporter ◽  
Bone Cancer Pain ◽  
Pain Model ◽  
Μ Opioid Receptor

Cancer Pain Model, Bone Cancer Pain Model

2006 ◽  
pp. 287-289
Author(s):  
Darryl T. Hamamoto ◽  
Donald A. Simone
Keyword(s):  
Cancer Pain ◽  
Bone Cancer ◽  
Bone Cancer Pain ◽  
Pain Model

scholarly journals Spinal cannabinoid receptor 2 activation reduces hypersensitivity associated with bone cancer pain and improves the integrity of the blood–spinal cord barrier

2020 ◽  
Vol 45 (10) ◽  
pp. 783-791
Author(s):  
Chenchen Wang ◽  
Ke Xu ◽  
Yu Wang ◽  
Yanting Mao ◽  
Yulin Huang ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Mouse Model ◽  
Cancer Pain ◽  
Proinflammatory Cytokines ◽  
Cannabinoid Receptor ◽  
Bone Cancer ◽  
Bone Cancer Pain ◽  
Pain Hypersensitivity ◽  
Cannabinoid Receptor 2 ◽  
Blood Spinal Cord Barrier

BackgroundDisruption of the blood–spinal cord barrier (BSCB) can facilitate inflammation that results in pain hypersensitivity. Proinflammatory cytokines produced by activated microglia and astrocytes damage the BSCB. This study aims to explore whether the BSCB is damaged in the bone cancer pain (BCP) model and to investigate a potential role and mechanism of JWH015 ((2-methyl-1-propyl-1H-indol-3-yl)−1-naphthalenylmethanone), a selective cannabinoid receptor 2 (CB2R) agonist, in preserving the BSCB integrity in the BCP model.MethodsWe used a male mouse model of BCP. Pain hypersensitivity was measured over time. Evans blue dye extravasation, transmission electron microscopy and Western blotting were performed to investigate the permeability and structural integrity of the BSCB. Immunofluorescence staining and western blotting were used to investigate the effect of JWH015 on the activation of glial cells and the levels of proinflammatory cytokines.ResultsA single intrathecal injection of JWH015 ameliorated pain hypersensitivity, the BSCB disruption and microglia and astrocyte activation. Decreases in the expression of ZO-1 and claudin-5 were partially restored by JWH015. The levels of the proinflammatory cytokines interleukin-1β and tumor necrosis factor-α and the enzyme MMP9 were reduced by JWH015. However, all effects were prevented by pretreatment with a CB2R-selective antagonist, AM630 ((6-iodo-2-methyl-1-(2-morpholinoethyl)−1H-indol-3-yl)(4-methoxyphenyl)methanone).ConclusionsJWH015 alleviates neuroinflammation and maintains the BSCB integrity and permeability in a mouse model of BCP, which is probably mediated by inhibiting glial cells activation. This study reveals the new analgesic mechanism of JWH015 on BCP and provides a perspective to explore novel drugs that target the BSCB to control BCP.

scholarly journals Differential activation of the μ-opioid receptor by oxycodone and morphine in pain-related brain regions in a bone cancer pain model

2012 ◽  
Vol 168 (2) ◽  
pp. 375-388 ◽  
Author(s):  
Atsushi Nakamura ◽  
Minoru Hasegawa ◽  
Kazuhisa Minami ◽  
Tomoe Kanbara ◽  
Takako Tomii ◽  
...  
Keyword(s):  
Cancer Pain ◽  
Opioid Receptor ◽  
Bone Cancer ◽  
Brain Regions ◽  
Bone Cancer Pain ◽  
Pain Model ◽  
Differential Activation ◽  
Μ Opioid Receptor
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