Atypical adrenal insufficiency with failure of the pituitary feedback receptor. A case with associated diabetes mellitus and selective IgA deficiency with steatorrhea

Celiac disease is predominantly a disease of the small intestine characterized by chronic malabsorption in genetically susceptible individuals who ingest grains containing gluten, such as wheat, barley, and rye. Although previously believed to be uncommon, celiac disease may be present in up to 1% of the adult and children population. Celiac disease is associated frequently with iron-deficiency anemia, dermatitis herpetiformis, selective IgA deficiency, thyroid disorders, diabetes mellitus, and various connective tissue disorders but is rarely associated with cardiomyopathy.

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A girl case of insulin dependent diabetes mellitus associated with selective IgA deficiency and No. 9 chromosome aberration.

Japanese Journal of Clinical Immunology ◽

10.2177/jsci.12.224 ◽

1989 ◽

Vol 12 (2) ◽

pp. 224-230

Author(s):

Naoshi Hashimoto ◽

Shuichi Tomizawa ◽

Kenichiro Takano ◽

Takayuki Gomi ◽

Keiko Satoh ◽

...

Keyword(s):

Diabetes Mellitus ◽

Chromosome Aberration ◽

Insulin Dependent Diabetes Mellitus ◽

Iga Deficiency ◽

Insulin Dependent Diabetes ◽

Dependent Diabetes Mellitus ◽

Selective Iga Deficiency ◽

Insulin Dependent

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IgA Deficiency in type 1 Diabetes Mellitus patients

QJM ◽

10.1093/qjmed/hcaa052.055 ◽

2020 ◽

Vol 113 (Supplement_1) ◽

Author(s):

F H Abouali ◽

D S Sheha ◽

H M Elsayed ◽

N A Ibrahim ◽

S T Kamal ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Type 1 Diabetes Mellitus ◽

Female Gender ◽

Iga Deficiency ◽

P Value ◽

University Hospitals ◽

Diabetes Clinic ◽

Selective Iga Deficiency

Abstract Background Selective IgA deficiency (SIgAD) in Type 1 diabetes mellitus patients (T1DM) has been reported, but the exact prevalence of SIgAD in Egyptian adults with T1DM is not known. Aim of the Work The aim of this work was to measure serum IgA level in patients with T1DM as compared to healthy controls. Patients and Methods Our study was a case control study conducted on 50 adult patients with T1DM recruited from the outpatient diabetes clinic of Ain Shams University Hospitals, with 50 healthy participants of comparable age and sex included as controls. All patients enrolled in the study were subjected to detailed history taking, serum levels of IgA, IgG and IgM levels were measured by Nephlometry. Patients with low sIgG or sIgM were excluded. Results The mean age of patients’ group was 24.5 ± 5.3 years. We report that 30 out of 50 patients (60%) with T1DM had associated SIgAD with a female predominance (20 females (66.7%) had SIgAD compared to 10 males (33.3%)). We also found a statistically significant relationship between SIgAD and diabetic ketoacidosis (DKA) (P-value<0.001). Moreover, 6 out of 50 (12%) of T1DM patients had associated autoimmune diseases but their sIgA level was normal. Conclusion The current study displays 60% prevalence of SIgAD among Egyptian patients with T1DM, which is higher than reported in other populations. Moreover, our data show a higher prevalence of SIgAD in female gender.

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