scholarly journals IgA Deficiency in type 1 Diabetes Mellitus patients

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
F H Abouali ◽  
D S Sheha ◽  
H M Elsayed ◽  
N A Ibrahim ◽  
S T Kamal ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Female Gender ◽  
Iga Deficiency ◽  
P Value ◽  
University Hospitals ◽  
Diabetes Clinic ◽  
Selective Iga Deficiency

Abstract Background Selective IgA deficiency (SIgAD) in Type 1 diabetes mellitus patients (T1DM) has been reported, but the exact prevalence of SIgAD in Egyptian adults with T1DM is not known. Aim of the Work The aim of this work was to measure serum IgA level in patients with T1DM as compared to healthy controls. Patients and Methods Our study was a case control study conducted on 50 adult patients with T1DM recruited from the outpatient diabetes clinic of Ain Shams University Hospitals, with 50 healthy participants of comparable age and sex included as controls. All patients enrolled in the study were subjected to detailed history taking, serum levels of IgA, IgG and IgM levels were measured by Nephlometry. Patients with low sIgG or sIgM were excluded. Results The mean age of patients’ group was 24.5 ± 5.3 years. We report that 30 out of 50 patients (60%) with T1DM had associated SIgAD with a female predominance (20 females (66.7%) had SIgAD compared to 10 males (33.3%)). We also found a statistically significant relationship between SIgAD and diabetic ketoacidosis (DKA) (P-value<0.001). Moreover, 6 out of 50 (12%) of T1DM patients had associated autoimmune diseases but their sIgA level was normal. Conclusion The current study displays 60% prevalence of SIgAD among Egyptian patients with T1DM, which is higher than reported in other populations. Moreover, our data show a higher prevalence of SIgAD in female gender.

The prevalence of selective IgA deficiency in type 1 diabetes mellitus

Apmis ◽  
1992 ◽  
Vol 100 (7-12) ◽  
pp. 709-712 ◽  
Author(s):  
ROLAND S. LIBLAU ◽  
SOPHIE CAILLAT-ZUCMAN ◽  
ANNE-MARIE FISCHER ◽  
JEAN-FRANCOIS BACH ◽  
CHRISTIAN BOITARD
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Iga Deficiency ◽  
Selective Iga Deficiency

scholarly journals Clinical features, Epidemiology, Autoantibody status, HLA Haplotypes and Genetic Mechanisms of Type 1 diabetes mellitus among Children in Qatar

2021 ◽  
Author(s):  
Basma Haris ◽  
Ikhlak Ahmed ◽  
Najeeb Syed ◽  
Hakeem Almabrazi ◽  
Saras Saraswathi ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Clinical Features ◽  
P Value ◽  
Hla Dq ◽  
Genetic Mechanisms ◽  
Autoantibody Status ◽  
Hla Haplotypes

Abstract Aims - To describe the clinical features, epidemiology, autoantibody status, HLA haplotypes and genetic mechanisms of type 1 diabetes mellitus (T1DM). Methods - Patients (0–18 years) with diabetes were recruited. Clinical data was collected, autoantibodies and c-peptide were measured. Whole Genome Sequencing was performed. Genomic data analysis was compared with the known genes linked with T1DM and HLA alleles were studied. Results - 1096 patients had one or more antibody positivity. The incidence of T1DM in 2020 was 38.05 per 100,000 children and prevalence was 249.73. GAD65 was the most common autoantibody and IA2 was most specific. Variants in GSTCD, SKAP2, SLC9B1, BANK1 were most prevalent. An association of HLA haplotypes DQA1*03:01:01G (OR = 2.46, pvalue = 0.011) and DQB1*03:02:01G (OR = 2.43, p value = 0.022) was identified. Conclusions - In this first prospective study, IA2 autoantibody was the most specific, some patients only have ZnT8 or IA2 autoantibodies thus underlining the necessity of profiling all 4 antibodies. The genes associated with T1DM in the Arab population were different from those that are common in the Caucasian population. HLA-DQ was enriched in the Qatari patients suggesting that it can be considered a major risk factor at an early age.

scholarly journals Studying Studying the relationship between Dipeptidyl peptidase-4 enzyme level, Tumor necrosis factor alpha enzyme level, and insulin resistance in type 1 Diabetes Mellitus patients

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
H M Amer ◽  
M M M Mahdy ◽  
W E Saad ◽  
M N A Abdelsalam
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Serum Level ◽  
Type 1 Diabetes Mellitus ◽  
Enzyme Level ◽  
Venous Blood ◽  
P Value ◽  
Tnf Α ◽  
The Relationship

Abstract Background Type 1 diabetes mellitus (T1DM) is an inflammatory disease of the pancreatic islets that results in absolute insulin deficiency and the consecutive hyperglycemia due to immune-mediated beta cell destruction throughout the globe, the incidence of T1DM is increasing at 3% to 5% per year Purpose To study the relationship between DPP-4 serum level, TNF a concentration measurements, and insulin sensitivity in T1DM patient Patients and Methods Patients were selected from the inpatient department of National Institute of Diabetes and Endocrinology during Januaray 2017, venous blood samples were collected to measure Serum level of creatinine, C-peptide, HbA1c%, DPP-4, TNFα . Measurement of eGDR was done using the formula 24.31 - 12.2 x (WHR) – 3.29 x (BLP) – 0.57 X HbA1c Study Design Cross sectional study that included 80 patients with type 1 Diabetes, Results The study population was divided according to median eGDR value of 6.125 mg kg-1 min-1 The group with higher IR(eGDR≤ 6.125)had higher value of DPP-4 enzyme level (1127.3 ± 40.9 ng/ml vs. 870.6 ± 30.2 ng/ml, p < 0.001) and TNF α concentration (11.4 ± 4.8 pg/ml vs 5.3 ± 1.6 pg/ml, p < 0.001). TNF α concentration negatively correlated with eGDR (r= -0.515, p value <0.001) DPP-4 level negatively correlated with eGDR (r= -0.826 and p value <0.001) while DPP-4 was positively correlated with TNF α (r = 0.441 p value ≤ 0.001)

scholarly journals Thyroid Dysfunction in Type 1 Diabetes Mellitus in an Iranian Elderly Woman

2018 ◽  
Vol 4 (1) ◽  
pp. 15-18
Author(s):  
Mohadese Nemati ◽  
Elmira Roshani Asl ◽  
Venus Haghshenas ◽  
Siamak Rashidi ◽  
Zohre Ahmadi ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Thyroid Dysfunction ◽  
Elderly Women ◽  
Endocrine Disorders ◽  
Thyroid Disorder ◽  
Diabetes Clinic ◽  
Autoimmune Thyroid

Objective: Type 1 Diabetes mellitus (T1DM) and thyroid dysfunction consider as main metabolic and endocrine disorders. In previous studies, individuals with T1DM were susceptible to Thyroid disorders. The prevalence of clinical and subclinical Thyroid dysfunction have noticeable importance especially regarding women and their related stigma. Methods: The presented survey, a case-control study evaluated the thyroid dysfunction among T1DM elderly women referred to diabetes clinic of Tohid Hospital in Sanandaj city. The whole blood samples were attained from all individuals and then the following tests were done: fasting blood-sugar (FBS), Serum TSH, anti-Thyroperoxidase (Anti-TPO) and Free T4.Results: The prevalence of Thyroid disorder in examined patients was 17 percent and autoimmune Thyroid dysfunction disorder, that examined by positive test-result of Anti-TPO showed up in 10.2 percent of patients. Prevalence of sub-clinical Hypothyroidism was 13.2 percent; the clinical Hypothyroidism were 7.3 percent. Based on our data 2.9 percent of T1DM have subclinical Hyperthyroidism and 1.4 percent have clinical Hyperthyroidism. In our study, increased TSH level and existence of Anti-TPO in TIDM patients might be regarded as an additional TIDM problem in studied disease.Conclusion: This study confirmed the association between autoimmune Thyroid dysfunction (based on positive Serum-test of Anti-TPO) and T1DM.

scholarly journals Short-Term Effects of COVID-19 Lockdown in Italian Children and Adolescents with Type 1 Diabetes Mellitus: The Role of Separation Anxiety

2021 ◽  
Vol 18 (11) ◽  
pp. 5549
Author(s):  
Daniela Di Riso ◽  
Simone Bertini ◽  
Silvia Spaggiari ◽  
Francesca Olivieri ◽  
Silvana Zaffani ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Therapeutic Range ◽  
Separation Anxiety ◽  
Insulin Dose ◽  
Female Gender ◽  
Chronically Ill ◽  
Well Being

In March 2020, the Italian Government imposed mandatory home confinement to limit the spread of COVID-19. Few studies assessed the psychophysical impact of COVID-19 on chronically ill children. This study examined these effects on children with Type 1 Diabetes Mellitus (T1D) and their caregivers. Seventy-one patients (7–13 years) with T1D and their caregivers were administered a survey created ad hoc and some standardized questionnaires, assessing psychological well-being and anxiety. Medical data (physical and biochemical characteristics) were recorded before (T0, January–February) and after (T1, May–June) the lockdown. Paired Student t-test, Spearman two-tailed correlations, and a linear regression model were used for statistical analysis. Children at T1 showed higher BMI (body mass index), daily total and basal insulin dose, and time spent in therapeutic range, and they showed lower HbA1c (glycated hemoglobin), time spent above the therapeutic range, and standard deviations of the mean glucose values than at T0. A total of 32.9% scored in the clinical range for separation anxiety. The increase in separation anxiety was predicted by younger age, female gender, more recent T1D diagnosis, less time spent in therapeutic range at T1, and higher perceived fear of COVID-19 infection. In a pandemic context, separation anxiety may be stronger in younger females, with more recent T1D diagnosis and poor metabolic control, thus affecting the parent’s ability to manage diabetes and to support children’s autonomy.

scholarly journals Psychological and behavioral complications in children and adolescents with type 1 diabetes mellitus in Sohag

2021 ◽  
Vol 28 (1) ◽  
Author(s):  
Saber Hadad ◽  
Magda Mohamed Ali ◽  
Taher Abdelraheem Sayed
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Children And Adolescents ◽  
Conduct Problems ◽  
Emotional Problems ◽  
P Value ◽  
Peer Problems ◽  
Diabetic Children

Abstract Background Type 1 diabetes mellitus is a chronic disease mainly diagnosed in children and adolescents. It has multiple psychiatric comorbidities. Our aim in this study was to determine the prevalence of psychological and behavioral problems in children and adolescents diagnosed with type 1 diabetes and to find if there is a strong correlation between these problems and different epidemiological- and disease-related factors such as age of the child, duration of diabetes, and other risk factors. We conducted a cross-sectional study and compared between 564 children diagnosed with diabetes mellitus type 1 (who attended Specialized Health Insurance Clinic in Sohag City, Upper Egypt, during the year 2018/2020) and 564 non-diabetic children matched with the diabetic children for age, sex, and socio-economic status. We used “Strengths and Difficulties Questionnaire (SDQ)” to screen for behavioral, social, and emotional problems in diabetic and control children. “SDQ” is a 25-item brief behavioral screening questionnaire that consists of five subscales which are emotional problems, hyperactivity-inattention problems, conduct problems, peer problems, and prosocial behavior subscales. It generates total score and individual score for each subscale. Results In our study, we found that diabetic children had significantly higher prevalence of emotional and behavioral problems than control children (92.37% of diabetic children versus 20.2% of control children had abnormal total SDQ score with P value < 0.001). All subscales of SDQ except prosocial subscale were significantly affected in children with type 1 diabetes mellitus than control children with P value < 0.001. Certain factors were significantly associated with impaired subscales of SDQ scale. We found a positive correlation between age and emotional, hyperactivity and conduct problems as these problems were more frequent in older children. Female children had more hyperactivity and conduct problems than male children (68.6%, 71.7% vs. 58.0%, 62.0%, P 0.002 and 0.003, respectively) while male children were more affected by emotional problems than female children (68% vs. 57.4%, P 0.003). Peer problems were more prevalent in children of parents with higher educational level. Children with positive family history of diabetes were less affected by emotional problems than children with negative family history (50% vs.64.3%, P 0.04). Longer duration of disease was associated with increased prevalence of peer and emotional problems. Poor control of diabetes increased the prevalence of conduct and emotional problems (P 0.007 and 0.022, respectively). Conclusion Children with type 1 diabetes mellitus have more emotional, hyperactivity, conduct, and peer problems than non-diabetic children. These findings indicate a need to screen diabetic children and adolescents for behavioral and emotional problems and treat these problems if found.

scholarly journals Incidence and predictors of diabetic ketoacidosis among children with type 1 diabetes mellitus in Western Amhara Referral Hospitals, Northwestern Ethiopia, 2018: A Retrospective Follow-Up Study

2019 ◽  
Author(s):  
Melkamu Siferih Zeleke ◽  
Getiye Dejenu Kibret ◽  
Tsige Gebre ◽  
Molla Yigzaw Birhanu ◽  
Cheru Tesema Leshargie
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Diabetic Ketoacidosis ◽  
Insulin Dose ◽  
P Value ◽  
Follow Up Study ◽  
Referral Hospitals

Abstract Background Diabetic ketoacidosis remains a major cause of morbidity, hospitalizations and mortality in children with established type 1 diabetes mellitus. Therefore, this study aimed to determine the incidence and predictors of diabetic ketoacidosis among children with established type 1 diabetes mellitus at Western Amhara region.Method Institution-based retrospective follow-up study was done on 393 children with established type 1 diabetes mellitus registered between September 2013 and September 2017 in Western Amhara referral hospitals. The collected data was entered into Epidata version 4.2 and further analysis were done using STATA version 14.1. Negative Binomial Poisson Regression analysis model was used.Result The cumulative incidence and incidence density rate of diabetic ketoacidosis among children with established type 1 diabetes mellitus in western Amhara referral hospitals was 63.9% and 41.5 per 100 person-years respectively. The incidence of diabetic ketoacidosis increased with age at diagnosis [ARR:2.61, p-value<0.001], siblings only care givers [ARR:1.87, p-value <0.001], fathers only [ARR:1.51, p-value=0.004],omission of insulin (ARR:1.58, p-value <0.001), lower frequency of clinical visits [ARR:2.35, p-value=0.007] and baseline insulin dose >1.2 u/kg/day [ARR:1.39, p-value=0.015], diabetic education (no) [ARR:1.52, p-value=0.011]. But the risk was decreased with baseline insulin type (Lente and regular) (ARR; 0.73, p-value =0.006), base line insulin dose <0.6u/kg/day (ARR: 0.5, p-value=0.034) and community health insurance membership (no membership) [ARR: 0.49, p-value <0.001]. In general, this study revealed that a substantial number of patients had at least one episode of diabetic ketoacidosis and a higher rate of diabetic ketoacidosis.

scholarly journals Health-related quality of life of adolescents with type 1 diabetes mellitus

2019 ◽  
Vol 27 ◽  
Author(s):  
Maria Amélia de Souza ◽  
Roberto Wagner Junior Freire de Freitas ◽  
Luciane Soares de Lima ◽  
Manoel Antônio dos Santos ◽  
Maria Lúcia Zanetti ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
P Value ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related

Objective: To evaluate the health-related quality of life of adolescents with type 1 diabetes mellitus, associating it with socio-demographic, clinical and biochemical variables. Method: Cross-sectional study with 92 adolescents with type 1 diabetes mellitus. A form containing socio-demographic, clinical and biochemical variables was used, as well as the Diabetes Quality of Life for Youths questionnaire. Descriptive statistics and logistic regression were used for analysis. Results: Regarding socio-demographic variables, economic class showed statistically significant differences in relation to total Health Related Quality of Life (p-value =0.02) and the impact domain (p-value =0.009). However, the impact domain was more compromised. Diabetes-related complications (p-value =0.004), number of hospitalizations (p-value =0.01), number of daily insulin injections (p-value =0.02), glycated hemoglobin (p-value =0.002) and triglycerides (p-value =0.03) were associated with greater impairment of quality of life related to total health and greater dissatisfaction. Conclusion: Single male adolescents with lower level of education and high glycated hemoglobin levels were more likely to have lower health-related quality of life.

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