Fever in renal transplant recipients: Causes, prognostic significance and changing patterns at the University of Minnesota Hospital

1981 ◽  
Vol 71 (3) ◽  
pp. 345-351 ◽  
Author(s):  
Phillip K. Peterson ◽  
Henry H. Balfour ◽  
David S. Fryd ◽  
Ronald M. Ferguson ◽  
Richard L. Simmons
Keyword(s):  
Renal Transplant ◽  
Prognostic Significance ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
University Of Minnesota ◽  
Changing Patterns ◽  
The University ◽  
Minnesota Hospital

THE PROGNOSTIC SIGNIFICANCE OF POSITIVE CMV CULTURES DURING SURVEILLANCE OF RENAL TRANSPLANT RECIPIENTS

1993 ◽  
Vol 56 (1) ◽  
pp. 103-107 ◽  
Author(s):  
D. PILLAY ◽  
A. A. ALI ◽  
S. F. LIU ◽  
E. KOPS ◽  
P. SWENY ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Prognostic Significance ◽  
Renal Transplant Recipients ◽  
Transplant Recipients

scholarly journals Use of Leflunomide in Renal Transplant Recipients with Ganciclovir-Resistant/Refractory Cytomegalovirus Infection: A Case Series from the University of Chicago

2015 ◽  
Vol 5 (1) ◽  
pp. 96-105 ◽  
Author(s):  
W. James Chon ◽  
Pradeep V. Kadambi ◽  
Chang Xu ◽  
Yolanda T. Becker ◽  
Piotr Witkowski ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Medical Center ◽  
Case Series ◽  
Deceased Donor ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
University Of Chicago ◽  
Kidney Transplants ◽  
Cmv Infection ◽  
The University

Introduction: Although antiviral prophylaxis for cytomegalovirus (CMV) is widely used, CMV infection remains common in renal transplant recipients with adverse consequences. Methods: We report 5 cases of renal transplant recipients with resistant CMV infection who were successfully managed with leflunomide at the University of Chicago Medical Center. Results: Five renal transplant recipients (2 simultaneous pancreas/kidney transplants, 3 deceased donor kidney transplants) were diagnosed with GCV-resistant CMV infection from 2003 to 2011. Of the 4 patients who had resistance genotype testing, 3 showed a UL97 mutation and 1 patient had a clinically resistant CMV infection. All patients received CMV prophylaxis with valganciclovir for 3 months. The number of days from the date of transplant to viremia ranged from 38 to 458 days (median 219). All 5 patients received other antiviral agents (e.g. ganciclovir, foscarnet), and in 4 patients, viremia was cleared before leflunomide was initiated as consolidation (or maintenance) therapy. Conclusion: Leflunomide was well tolerated and successful in preventing recurrence of viremia in renal transplant recipients with resistant CMV infection. The beneficial effect of leflunomide in this setting warrants further investigation.

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