Central Corneal Endothelial Cell Density and Central Corneal Thickness in Ocular Hypertension and Primary Open-Angle Glaucoma

The Ocular Hypertension Treatment Study (OHTS) was a randomized, open, placebo-controlled, clinical trial to determine whether reducing intraocular pressure (IOP) in eyes with ocular hypertension (OHTN) reduced the risk of developing primary open-angle glaucoma (POAG). The study found that topical ocular hypotensive medication was effective in delaying or preventing the development of glaucomatous optic neuropathy in eyes with OHTN. However, the authors recommended stratifying risk in patients with OHTN using variables such as baseline age, vertical and horizontal cup-to-disc ratio, visual field pattern standard deviation, IOP, and, especially, central corneal thickness.

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Study of Changes in Corneal Thickness and Corneal Endothelial Cell Density after Phacoemulsification Cataract Surgery

Journal of Evolution of Medical and Dental Sciences ◽

10.14260/jemds/2021/187 ◽

2021 ◽

Vol 10 (12) ◽

pp. 866-872

Author(s):

Rajiv Pardasani ◽

Sohan Lohiya

Keyword(s):

Endothelial Cell ◽

Cell Density ◽

Coefficient Of Variation ◽

Central Corneal Thickness ◽

Corneal Thickness ◽

Cell Loss ◽

Corneal Endothelial Cell ◽

Endothelial Cell Density ◽

P Value ◽

Corneal Endothelial Cell Density

BACKGROUND Phacoemulsification is a common surgery for cataract. The endothelium comprises of hexagonal cells which in single layer is essential for maintaining the transparency of the cornea. We wanted to compare endothelial cell density (ECD), central corneal thickness (CCT), coefficient of variability, and hexagonality of endothelial cells before and after phacoemulsification surgery. we also wanted to evaluate the endothelial cell loss after phacoemulsification surgery. METHODS A rural hospital-based prospective observational study with 120 patients was conducted in a hospital based setting utilising the data of patient’s eye by considering inclusion and exclusion criteria, before and after phacoemulsification surgery by using noncontact specular microscope. RESULTS The mean endothelial cell density significantly decreased postoperatively at day one, 4th week, 12th week. The mean central corneal thickness increased significantly at postoperative day one, then subsequently decreased at postoperative 4th week and 12th week (P value = 0.0001), but never reached the preoperative value. There was a significant change in coefficient of variation and hexagonality postoperatively (P value = 0.0001). CONCLUSIONS The primary result is the change in corneal endothelial cell density (cells per square millimetre of the corneal surface) which is decreased, and the central corneal thickness calculated in micro meter is increased. As endothelial cells do not replicate, to reimburse cell loss there are changes in coefficient of variation and hexagonality after phacoemulsification surgery. KEY WORDS Corneal Endothelial Cell Density, Central Corneal Thickness, Coefficient of Variation, Hexagonality, Phacoemulsification, Specular Microscope

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Evaluation of the Effect of Various Intra Operative Surgical Complications on Central Corneal Endothelial Cell Density and Central Corneal Thickness- A Prospective Study

Journal of Medical Science And clinical Research ◽

10.18535/jmscr/v7i7.174 ◽

2019 ◽

Vol 7 (7) ◽

Author(s):

Dr Sachin Tammannavar ◽

Keyword(s):

Endothelial Cell ◽

Prospective Study ◽

Cell Density ◽

Surgical Complications ◽

Central Corneal Thickness ◽

Corneal Thickness ◽

Corneal Endothelial Cell ◽

Endothelial Cell Density ◽

Corneal Endothelial Cell Density ◽

A Prospective Study

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Corneal Endothelial Cell Density and Morphology in Healthy Turkish Eyes

Journal of Ophthalmology ◽

10.1155/2014/852624 ◽

2014 ◽

Vol 2014 ◽

pp. 1-5 ◽

Cited By ~ 13

Author(s):

Ceyhun Arıcı ◽

Osman Sevki Arslan ◽

Funda Dikkaya

Keyword(s):

Endothelial Cell ◽

Cell Size ◽

Cell Density ◽

Central Corneal Thickness ◽

Corneal Thickness ◽

Corneal Endothelial Cell ◽

Endothelial Cell Density ◽

Japanese American ◽

Significant Difference ◽

Corneal Endothelial Cell Density

Purpose. To describe the normative values of corneal endothelial cell density, morphology, and central corneal thickness in healthy Turkish eyes.Methods. Specular microscopy was performed in 252 eyes of 126 healthy volunteers (M : F, 42 : 84). Parameters studied included mean endothelial cell density (MCD), mean cell area (MCA), coefficient of variation (CV) in cell size, percentage of hexagonal cells, and central corneal thickness (CCT).Results. The mean age of volunteers was44.3±13.5(range, 20 to 70) years. There was a statistically significant decrease in MCD (P<0.001; correlation, −0.388) and percentage of hexagonal cells, (P<0.001; correlation, −0.199) with age. There was also a statistically significant increase in MCA (P<0.001; correlation, 0.363) with increasing age. There was no statistically significant difference in MCD, MCA, CV in cell size, percentage of hexagonal cells, and CCT between genders and there was also no significant difference in these parameters between fellow eyes of subjects.Conclusions. Normotive data for the endothelium in the Turkish population are reported. Endothelial cell density in the Turkish eyes is less than that described in the Japanese, American, Chinese, and Filipino eyes and higher than that described in Indian, Thai, and Iranian eyes.

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