scholarly journals Corneal Endothelial Cell Density and Morphology in Healthy Turkish Eyes

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Ceyhun Arıcı ◽  
Osman Sevki Arslan ◽  
Funda Dikkaya
Keyword(s):  
Endothelial Cell ◽  
Cell Size ◽  
Cell Density ◽  
Central Corneal Thickness ◽  
Corneal Thickness ◽  
Corneal Endothelial Cell ◽  
Endothelial Cell Density ◽  
Japanese American ◽  
Significant Difference ◽  
Corneal Endothelial Cell Density

Purpose. To describe the normative values of corneal endothelial cell density, morphology, and central corneal thickness in healthy Turkish eyes.Methods. Specular microscopy was performed in 252 eyes of 126 healthy volunteers (M : F, 42 : 84). Parameters studied included mean endothelial cell density (MCD), mean cell area (MCA), coefficient of variation (CV) in cell size, percentage of hexagonal cells, and central corneal thickness (CCT).Results. The mean age of volunteers was44.3±13.5(range, 20 to 70) years. There was a statistically significant decrease in MCD (P<0.001; correlation, −0.388) and percentage of hexagonal cells, (P<0.001; correlation, −0.199) with age. There was also a statistically significant increase in MCA (P<0.001; correlation, 0.363) with increasing age. There was no statistically significant difference in MCD, MCA, CV in cell size, percentage of hexagonal cells, and CCT between genders and there was also no significant difference in these parameters between fellow eyes of subjects.Conclusions. Normotive data for the endothelium in the Turkish population are reported. Endothelial cell density in the Turkish eyes is less than that described in the Japanese, American, Chinese, and Filipino eyes and higher than that described in Indian, Thai, and Iranian eyes.

scholarly journals Study of Changes in Corneal Thickness and Corneal Endothelial Cell Density after Phacoemulsification Cataract Surgery

2021 ◽  
Vol 10 (12) ◽  
pp. 866-872
Author(s):  
Rajiv Pardasani ◽  
Sohan Lohiya
Keyword(s):  
Endothelial Cell ◽  
Cell Density ◽  
Coefficient Of Variation ◽  
Central Corneal Thickness ◽  
Corneal Thickness ◽  
Cell Loss ◽  
Corneal Endothelial Cell ◽  
Endothelial Cell Density ◽  
P Value ◽  
Corneal Endothelial Cell Density

BACKGROUND Phacoemulsification is a common surgery for cataract. The endothelium comprises of hexagonal cells which in single layer is essential for maintaining the transparency of the cornea. We wanted to compare endothelial cell density (ECD), central corneal thickness (CCT), coefficient of variability, and hexagonality of endothelial cells before and after phacoemulsification surgery. we also wanted to evaluate the endothelial cell loss after phacoemulsification surgery. METHODS A rural hospital-based prospective observational study with 120 patients was conducted in a hospital based setting utilising the data of patient’s eye by considering inclusion and exclusion criteria, before and after phacoemulsification surgery by using noncontact specular microscope. RESULTS The mean endothelial cell density significantly decreased postoperatively at day one, 4th week, 12th week. The mean central corneal thickness increased significantly at postoperative day one, then subsequently decreased at postoperative 4th week and 12th week (P value = 0.0001), but never reached the preoperative value. There was a significant change in coefficient of variation and hexagonality postoperatively (P value = 0.0001). CONCLUSIONS The primary result is the change in corneal endothelial cell density (cells per square millimetre of the corneal surface) which is decreased, and the central corneal thickness calculated in micro meter is increased. As endothelial cells do not replicate, to reimburse cell loss there are changes in coefficient of variation and hexagonality after phacoemulsification surgery. KEY WORDS Corneal Endothelial Cell Density, Central Corneal Thickness, Coefficient of Variation, Hexagonality, Phacoemulsification, Specular Microscope

scholarly journals Change in corneal endothelial cell density after phacoemulsification in patients with type II diabetes mellitus

2019 ◽  
Vol 35 (5) ◽  
Author(s):  
Muhammad Khalid ◽  
Muhammad Kashif Hanif ◽  
Qamar Ul Islam ◽  
Muhammad Asim Mehboob
Keyword(s):  
Endothelial Cell ◽  
Cell Density ◽  
Type Ii Diabetes Mellitus ◽  
Corneal Endothelial Cell ◽  
Endothelial Cell Density ◽  
Diabetic Patients ◽  
Type Ii ◽  
Significant Difference ◽  
Corneal Endothelial Cell Density ◽  
Study Population

Objective: To compare the mean change in Corneal Endothelial cell Density (CED), from baseline (pre-operative value), two months after phacoemulsification cataract surgery between type II diabetic patients and non-diabetic patients. Methods: This prospective stratified controlled study was conducted at PNS Shifa Hospital, Karachi. 80 eyes of 72 type II diabetic patients and 80 eyes of 77 non diabetic controls, having Nuclear Opalescence (NO) grades 2 and 3 on slit lamp examination underwent phacoemulsification surgery. CED was measured in cells/mm2, of concerned eye of each subject preoperatively and 2 months post operatively using specular microscope. The difference in mean CED change between the two groups after surgery was analyzed. Results: Mean age of study population was 61.41± 6.76 years. Out of study population, 92 (57.5%) were males and 68 (42.5%) were females. There was a statistically significant difference between both groups in terms of mean post-operative CED, mean change in CED and mean frequency change in CED (p <0.05). There was no statistically significant difference between both groups in age, gender, laterality of eyes and mean pre-operative CED, (p >0.05). Difference of pre-operative CED from post-operative CED in each group was statistically significant. Conclusion: There is a significant difference between diabetic population and normal population in terms of corneal endothelial loss after uneventful phacoemulsification cataract surgery. doi: https://doi.org/10.12669/pjms.35.5.596 How to cite this:Khalid M, Hanif MK, Qamar ul Islam, Mehboob MA. Change in corneal endothelial cell density after phacoemulsification in patients with type II diabetes mellitus. Pak J Med Sci. 2019;35(5):---------. doi: https://doi.org/10.12669/pjms.35.5.596 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Corneal Endothelial Cell Density and Morphology in Healthy Egyptian Eyes

2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Marwa Mahmoud Abdellah ◽  
Hatem Gamal Ammar ◽  
Mohamed Anbar ◽  
Engy Mohammed Mostafa ◽  
Mahmoud Mohamed Farouk ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Cell Density ◽  
Corneal Thickness ◽  
Corneal Transplantation ◽  
Corneal Endothelial Cell ◽  
Endothelial Cell Density ◽  
Specular Microscopy ◽  
Cell Area ◽  
Corneal Endothelial Cell Density ◽  
The Mean

Purpose. To evaluate the corneal endothelial cell density and morphology in normal Egyptian eyes. Methods. In total, 568 healthy eyes of 568 Egyptian volunteers aged 20 to 85 years were examined using noncontact specular microscopy for the central corneal thickness (CCT), mean endothelial cell density (MCD), coefficient of variation (CV) in cell area, mean cell area (MCA), and hexagonal cell (Hex) percentage. Variables were compared between sexes and between different age groups. Results. The mean CCT, MCD, and MCA were 514.45 ± 43.04 μm, 2647.50 ± 382.62 cells/mm2, and 390.59 ± 149.94 μm2, respectively. MCD and MCA showed no significant differences between men and women (P=0.171 and 0.099, respectively), whereas CV (%) and Hex (%) showed significant differences (P=0.024 and 0.015, respectively). CCT (P=0.007, r = −0.113) and MCD (P<0.001, r = −0.357) exhibited a significant negative correlation with age, whereas CV (%) (P<0.001, r = 0.341) and MCA (P=0.008, r = 0.111) exhibited a significant positive correlation. The mean rate of endothelial cell loss from 20 to 85 years of age was 0.3% per year. Conclusions. Our results provide normative data for the corneal endothelium in healthy Egyptian eyes, thus increasing the knowledge base for corneal endothelial cell parameters in healthy Egyptian eyes. Furthermore, our findings can be used as baseline values for comparisons between Egyptian and other populations and for studies of the endothelial cell reserve and capacity for intraocular surgery and corneal transplantation.

scholarly journals Change in Corneal Endothelial Cell Density after Baerveldt Shunt Implantation in Glaucoma Patients

2021 ◽  
Vol 73 (4) ◽  
pp. 252-258
Author(s):  
Ngamkae Ruangvaravate
Keyword(s):  
Endothelial Cell ◽  
Cell Density ◽  
Linear Mixed Model ◽  
Corneal Thickness ◽  
Corneal Endothelial Cell ◽  
Endothelial Cell Density ◽  
Shunt Implantation ◽  
Corneal Endothelial Cell Density ◽  
One Year ◽  
Over Time

Objective: To evaluate changes in corneal endothelial cells density (EDC) at 1 one, six, and twelve months after Baerveldt shunt implantation. Materials and Methods: This prospective study included 24 patients who underwent Baerveldt shunt implantation for refractory glaucoma, and who had one full year of post-surgical follow-up. Best corrected visual acuity (BCVA), intraocular pressure (IOP), number of glaucoma medications, central corneal thickness (CCT), corneal endothelial cell density (EDC), and morphology in central, inferior, and superotemporal (stEDC) areas were recorded at baseline, and 1, 6, and 12 months after surgery. Distance between the tip of tube to corneal endothelium (TTC) was measured using optical coherence tomography at one month after surgery. Results: Twenty-four eyes from 24 patients were analyzed. Sixty-two percent were primary open-angle glaucoma, and 73.1% of patients had previous trabeculectomy. Mean BCVA was not significantly changed. The mean IOP at six months (12.2±4.35 mmHg) and at one year (11.1±4.31 mmHg) was significantly lower than baseline (20.1±9.24 mmHg) (p<0.001 and p<0.001 respectively). Median (min, max) number of anti-glaucoma medications significantly decreased from 4 (1, 6) at baseline to 1 (0, 3) and 1 (0, 3) at six months and one year after surgery (p<0.001 and p<0.001, respectively). Mean baseline stEDC was 1,527±644 cells/mm2. From linear mixed model, stEDC showed the most significantly decreasing slope (y=1365.54 – 18.6125t, p=0.014), and CCT showed a significant increase over time (y=533.65 + 1.8853t). Pearson’s correlation coefficient between TTC and stEDC change at one year was not statistically significant (-0.403, p=0.172). Conclusion: After Baerveldt shunt implantation, EDC loss over time was found in the area closest to where the tube was placed in addition to increasing CCT. Distance from tip of tube to cornea is not the only factor that can cause EDC loss after shunt implantation. Additional study to identify other possible mechanisms is warranted.

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