Abstract
Background
Breast cancer is one of the most common malignancies and the most common cause of death women around worldwide. Recently, viral etiology theory has been proposed on physiopathology of the breast cancer.
Method:
In a retrospective study, to study of non-familial agents and a viral factors breast cancer, the Real time PCR were used to detect Kaposi Herpes virus or Human herpes virus type8(HHV8) in 138 patients with breast cancer.
Result
Out of the 138 embedded paraffin breast cancer tissues, 17(12.3%) were positive for HHV8. Among the viral positive breast cancer samples, 8 samples (10.95%) were positive in intermediate grade and 10 samples (11.9%) were positive in 40–60 years old age group. There was no significant relation between grades of tumors and there was a significant relation between age and breast cancer.
Conclusion
Out of 17 positive samples 15 samples (88.23%) and 2 samples (11.77%) had more than 5 and less than 3 infected lymph node. In this study, there was a significant relation between infected lymph node and positive samples with HHV-8. Therefore, it is likely that the lymphocytes infected with HHV-8 virus may be the source of cancer cells and may also cause infected cells to spread to other organs, as well as the treatment of these patients is difficult.
Possible associationo virus-induced deoxyribonucleic acid polymerase and deoxyribonucleic acid exonuclease in herpes-virus-infected cells
