Changes in L-ornithine decarboxylase activity during the cell cycle

1976 ◽  
Vol 71 (1) ◽  
pp. 99-105 ◽  
Author(s):  
Olle Heby ◽  
Joe W. Gray ◽  
Patricia A. Lindl ◽  
Laurence J. Marton ◽  
Charles B. Wilson
1978 ◽  
Vol 39 (02) ◽  
pp. 496-503 ◽  
Author(s):  
P A D’Amore ◽  
H B Hechtman ◽  
D Shepro

SummaryOrnithine decarboxylase (ODC) activity, the rate-limiting step in the synthesis of polyamines, can be demonstrated in cultured, bovine, aortic endothelial cells (EC). Serum, serotonin and thrombin produce a rise in ODC activity. The serotonin-induced ODC activity is significantly blocked by imipramine (10-5 M) or Lilly 11 0140 (10-6M). Preincubation of EC with these blockers together almost completely depresses the 5-HT-stimulated ODC activity. These observations suggest a manner by which platelets may maintain EC structural and metabolic soundness.


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