Effects of deuterium oxide on nucleic acid metabolism in rabbit-bone-marrow cells

1961 ◽  
Vol 53 (1) ◽  
pp. 223-224 ◽  
Author(s):  
Jack C. Wilson ◽  
James S. Dinning
1974 ◽  
Vol 23 (15) ◽  
pp. 2155-2163 ◽  
Author(s):  
Larrel W. Harris ◽  
Vincent F. Garry ◽  
Robert D. Moore

1969 ◽  
Vol 129 (6) ◽  
pp. 1261-1273 ◽  
Author(s):  
M. Richter ◽  
N. I. Abdou

Bone marrow cells obtained from rabbits of one allotype were injected into irradiated rabbits of a different allotype. The recipients were also injected with sheep red blood cells, and their spleen cells were tested for plaque-forming capacity 7 days later. Spleen cells of all recipients gave large numbers of plaques as did spleen cells incubated with antiserum, directed toward donor allotype. However, incubation of the recipient spleen cells with antiserum directed toward recipient allotype completely suppressed plaque formation. These results demonstrate that antibody-formation in irradiated recipients of transferred lymphoid cells is a property of the recipient animal and that the antibody-forming cell is relatively irradiation-resistant. It was also demonstrated that only viable normal bone marrow cells are capable of transferring antibody-forming capacity to irradiated recipient rabbits. Neither sonicates nor heat-killed preparations of normal rabbit bone marrow cells possessed this capacity.


Sign in / Sign up

Export Citation Format

Share Document