Abstract.
Comparative immunohistochemical localization of γ-melanocyte stimulating hormone (γ-MSH) and adrenocorticotrophic hormone (ACTH1-24) was studied on bovine and human pituitaries. By the combination of peroxidase labelled antibody method and 'mirror' sections, it was clearly demonstrated that γ-MSH and ACTH were present in the same cells in pars distalis and in pars intermedia or zona intermedia of the bovine and human pituitaries, respectively. Our studies further supported the concept of the production of precursor molecule for these peptides in pars distalis as well as in pars (zona) intermedia.
Cocaine- and Amphetamine-Regulated Transcript (CART) Is Colocalized with the Orexigenic Neuropeptide Y and Agouti-Related Protein and Absent from the Anorexigenic α-Melanocyte-Stimulating Hormone Neurons in the Infundibular Nucleus of the Human Hypothalamus