scholarly journals Cocaine- and Amphetamine-Regulated Transcript (CART) Is Colocalized with the Orexigenic Neuropeptide Y and Agouti-Related Protein and Absent from the Anorexigenic α-Melanocyte-Stimulating Hormone Neurons in the Infundibular Nucleus of the Human Hypothalamus

Endocrinology ◽  
2007 ◽  
Vol 148 (9) ◽  
pp. 4276-4281 ◽  
Author(s):  
Judit Menyhért ◽  
Gábor Wittmann ◽  
Ronald M. Lechan ◽  
Éva Keller ◽  
Zsolt Liposits ◽  
...  
Keyword(s):  
Neuropeptide Y ◽  
Related Protein ◽  
Human Hypothalamus ◽  
Melanocyte Stimulating Hormone ◽  
Agouti Related Protein ◽  
Stimulating Hormone

Mutational analysis of melanocortin-4 receptor, agouti-related protein, and α-melanocyte-stimulating hormone genes in severely obese children

2001 ◽  
Vol 139 (2) ◽  
pp. 204-209 ◽  
Author(s):  
Béatrice Dubern ◽  
Karine Clément ◽  
Véronique Pelloux ◽  
Philippe Froguel ◽  
Jean-Philippe Girardet ◽  
...  
Keyword(s):  
Mutational Analysis ◽  
Related Protein ◽  
Obese Children ◽  
Melanocyte Stimulating Hormone ◽  
Melanocortin 4 Receptor ◽  
Severely Obese ◽  
Agouti Related Protein ◽  
Stimulating Hormone

scholarly journals Regulation of adipose tissue leptin secretion by alpha-melanocyte-stimulating hormone and agouti-related protein: further evidence of an interaction between leptin and the melanocortin signalling system

2004 ◽  
Vol 32 (1) ◽  
pp. 145-153 ◽  
Author(s):  
N Hoggard ◽  
L Hunter ◽  
JS Duncan ◽  
DV Rayner
Keyword(s):  
Adipose Tissue ◽  
Energy Balance ◽  
Receptor Subtype ◽  
Related Protein ◽  
Melanocortin System ◽  
Rat Adipocytes ◽  
Melanocyte Stimulating Hormone ◽  
Agouti Related Protein ◽  
Stimulating Hormone

The central role of the melanocortin system in the regulation of energy balance has been studied in great detail. However, the functions of circulating melanocortins and the roles of their peripheral receptors remain to be elucidated. There is increasing evidence of a peripheral action of melanocortins in the regulation of leptin production by adipocytes. Here we investigate the interaction of alpha-melanocyte stimulating hormone (alpha-MSH) and agouti-related protein (AgRP) in the regulation of leptin secretion from cultured rat adipocytes and examine the changes in circulating alpha-MSH and AgRP in lean and obese rodents after hormonal and energetic challenge. Leptin secretion (measured by ELISA) and gene expression (by real-time quantitative PCR) of differentiated rat adipocytes cultured in vitro were inhibited by the administration of alpha-MSH (EC50=0.24 nM), and this effect was antagonised by antagonists of the melanocortin receptors MC4R and MC3R (AgRP and SHU9119). The presence of MC4R in rat adipocytes (RT-PCR and restriction digest) supports the involvement of this receptor subtype in this interaction. Leptin administered to ob/ob mice in turn increases the release of alpha-MSH into the circulation, suggesting a possible feedback loop between the site of alpha-MSH release and the release of leptin from the adipose tissue. However, the physiological significance of this putative feedback probably depends upon the underlying state of energy balance, since in the fasting state low plasma alpha-MSH is paralleled by low plasma leptin.

Sign in / Sign up

Export Citation Format

Share Document