In vitro myelin basic protein synthesis in the PNS and CNS of myelin deficient (mld) mutant mice

1983 ◽  
Vol 277 (2) ◽  
pp. 386-388 ◽  
Author(s):  
Helga Ginalski-Winkelmann ◽  
Guillermina Almazan ◽  
Jean-Marie Matthieu
Keyword(s):  
Protein Synthesis ◽  
Myelin Basic Protein ◽  
Basic Protein ◽  
Mutant Mice ◽  
Myelin Deficient

Inefficient Transcription of the Myelin Basic Protein Gene Possibly Causes Hypomyelination in Myelin-Deficient Mutant Mice

1987 ◽  
Vol 48 (2) ◽  
pp. 470-476 ◽  
Author(s):  
Hideyuki Okano ◽  
Masayuki Miura ◽  
Akira Moriguchi ◽  
Kazuhiro Ikenaka ◽  
Yasuzo Tsukada ◽  
...  
Keyword(s):  
Myelin Basic Protein ◽  
Basic Protein ◽  
Protein Gene ◽  
Mutant Mice ◽  
Deficient Mutant ◽  
Myelin Basic Protein Gene ◽  
Myelin Deficient

α2 isoform of Na+,K+-ATPase via Na+,Ca2+ exchanger modulates myelin basic protein synthesis in oligodendrocyte lineage cells in vitro

Cell Calcium ◽  
2018 ◽  
Vol 73 ◽  
pp. 1-10 ◽  
Author(s):  
Jens Hammann ◽  
Davide Bassetti ◽  
Robin White ◽  
Heiko J. Luhmann ◽  
Sergei Kirischuk
Keyword(s):  
Protein Synthesis ◽  
Myelin Basic Protein ◽  
Basic Protein

In vitro carboxymethylation of myelin basic protein

1986 ◽  
Vol 4 (2) ◽  
pp. 143-151 ◽  
Author(s):  
Toshihiko Innami ◽  
Masaharu Miyake ◽  
Yasuo Kakimoto
Keyword(s):  
Myelin Basic Protein ◽  
Basic Protein

Intracellular ion signaling influences myelin basic protein synthesis in oligodendrocyte precursor cells

Cell Calcium ◽  
2016 ◽  
Vol 60 (5) ◽  
pp. 322-330 ◽  
Author(s):  
Maike Friess ◽  
Jens Hammann ◽  
Petr Unichenko ◽  
Heiko J. Luhmann ◽  
Robin White ◽  
...  
Keyword(s):  
Protein Synthesis ◽  
Myelin Basic Protein ◽  
Basic Protein ◽  
Precursor Cells ◽  
Oligodendrocyte Precursor Cells ◽  
Oligodendrocyte Precursor

scholarly journals Translation of myelin basic protein mRNA in oligodendrocytes is regulated by integrin activation and hnRNP-K

2011 ◽  
Vol 192 (5) ◽  
pp. 797-811 ◽  
Author(s):  
Lisbeth S. Laursen ◽  
Colin W. Chan ◽  
Charles ffrench-Constant
Keyword(s):  
Protein Synthesis ◽  
Myelin Basic Protein ◽  
Myelin Sheath ◽  
Basic Protein ◽  
Inhibitory Effect ◽  
Integrin Activation ◽  
Hnrnp K ◽  
Sheath Formation ◽  
The Central Nervous System ◽  
Mrna Binding

Myelination in the central nervous system provides a unique example of how cells establish asymmetry. The myelinating cell, the oligodendrocyte, extends processes to and wraps multiple axons of different diameter, keeping the number of wraps proportional to the axon diameter. Local regulation of protein synthesis represents one mechanism used to control the different requirements for myelin sheath at each axo–glia interaction. Prior work has established that β1-integrins are involved in the axoglial interactions that initiate myelination. Here, we show that integrin activation regulates translation of a key sheath protein, myelin basic protein (MBP), by reversing the inhibitory effect of the mRNA 3′UTR. During oligodendrocyte differentiation and myelination α6β1-integrin interacts with hnRNP-K, an mRNA-binding protein, which binds to MBP mRNA and translocates from the nucleus to the myelin sheath. Furthermore, knockdown of hnRNP-K inhibits MBP protein synthesis during myelination. Together, these results identify a novel pathway by which axoglial adhesion molecules coordinate MBP synthesis with myelin sheath formation.

In vitro and in vivo phosphorylation of myelin basic protein by cerebral protein kinase

Nature ◽  
1974 ◽  
Vol 249 (5453) ◽  
pp. 150-151 ◽  
Author(s):  
EISHICHI MIYAMOTO ◽  
SHIRO KAKIUCHI ◽  
YASUO KAKIMOTO
Keyword(s):  
Protein Kinase ◽  
Myelin Basic Protein ◽  
Basic Protein
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