Regional distribution of substance P, neurokinin α and neurokinin β in rat spinal cord, nerve roots and dorsal root ganglia, and the effects of dorsal root section or spinal transection

1985 ◽  
Vol 359 (1-2) ◽  
pp. 152-157 ◽  
Author(s):  
Tatsuji Ogawa ◽  
Ichiro Kanazawa ◽  
Sadao Kimura
Keyword(s):  
Spinal Cord ◽  
Substance P ◽  
Dorsal Root Ganglia ◽  
Dorsal Root ◽  
Regional Distribution ◽  
Rat Spinal Cord ◽  
Nerve Roots ◽  
Spinal Transection ◽  
Root Section

Distribution of substance P-like immunoreactivity in the spinal cord and dorsal root ganglia of the human foetus and infant

Neuroscience ◽  
1983 ◽  
Vol 10 (1) ◽  
pp. 41-55 ◽  
Author(s):  
Y. Charnay ◽  
C. Paulin ◽  
J.-A. Chayvialle ◽  
P.M. Dubois
Keyword(s):  
Spinal Cord ◽  
Substance P ◽  
Dorsal Root Ganglia ◽  
Dorsal Root ◽  
Human Foetus

In situ hybridization study of μ- and κ-opioid receptor mRNAs in the rat spinal cord and dorsal root ganglia

1994 ◽  
Vol 168 (1-2) ◽  
pp. 97-100 ◽  
Author(s):  
Keiko Maekawa ◽  
Masabumi Minami ◽  
Kazuki Yabuuchi ◽  
Takashi Toya ◽  
Yoshikazu Katao ◽  
...  
Keyword(s):  
Spinal Cord ◽  
In Situ Hybridization ◽  
Opioid Receptor ◽  
Dorsal Root Ganglia ◽  
Dorsal Root ◽  
Hybridization Study ◽  
Rat Spinal Cord ◽  
Receptor Mrnas

scholarly journals Sensation of Abdominal Pain Induced by Peritoneal Carcinomatosis Is Accompanied by Changes in the Expression of Substance P and μ-Opioid Receptors in the Spinal Cord of Mice

2012 ◽  
Vol 117 (4) ◽  
pp. 847-856 ◽  
Author(s):  
Masami Suzuki ◽  
Minoru Narita ◽  
Minami Hasegawa ◽  
Sadayoshi Furuta ◽  
Tomoyuki Kawamata ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Abdominal Pain ◽  
Substance P ◽  
Peritoneal Carcinomatosis ◽  
Opioid Receptor ◽  
Dorsal Root Ganglia ◽  
Dorsal Root ◽  
Receptor Expression ◽  
Tumor Bearing ◽  
Μ Opioid Receptor

Background Patients with peritoneal carcinomatosis often report abdominal pain, which is relatively refractory to morphine. It has been considered that a new animal model is required to investigate the mechanism of abdominal pain for the development of optimal treatments for this type of pain. Methods To prepare a peritoneal carcinomatosis model, highly peritoneal-seeding gastric cancer cells, 60As6, were implanted into the abdominal cavity. The nociceptive modality for pain-related behavior was assessed in terms of withdrawal behavior in response to mechanical stimuli and hunching behavior. Tissue samples from mouse dorsal root ganglia and spinal cord were subject to immunohistochemistry and real-time reverse transcription polymerase chain reaction. Results Mice with peritoneal dissemination showed significant hypersensitivity of the abdomen to mechanical stimulation and spontaneous visceral pain-related behavior. There was a significant increase in c-Fos-positive cells in the spinal cord in tumor-bearing mice. Those mice exhibited a remarkable increase in substance P-positive neurons in the dorsal root ganglia (control vs. tumor, 15.4 ± 1.1 vs. 24.2 ± 3.6, P < 0.05, n = 3). A significant decreases in μ-opioid receptor expression mainly in substance P-positive neurons was observed in tumor-bearing mice (69.3 ± 4.9 vs. 38.7 ± 0.9, P < 0.05, n = 3), and a relatively higher dose of morphine was required to significantly reverse the abdominal hypersensitivity. Conclusion Both the up-regulation of substance P and down-regulation of μ-opioid receptor seen in the dorsal root ganglia may be, at least in part, responsible for the abdominal pain-like state associated with peritoneal carcinomatosis.

Uptake and transport of inorganic mercury in rat spinal cord and dorsal root ganglia

1995 ◽  
Vol 78 ◽  
pp. 74
Author(s):  
Jørgan D. Schiønning ◽  
Marianne Korsgaard ◽  
Gorm Danscher ◽  
Bjarne Møller-Madsen
Keyword(s):  
Spinal Cord ◽  
Dorsal Root Ganglia ◽  
Dorsal Root ◽  
Inorganic Mercury ◽  
Rat Spinal Cord ◽  
Uptake And Transport

Cholecystokinin mRNA detection in rat spinal cord motoneurons but not in dorsal root ganglia neurons

1991 ◽  
Vol 123 (1) ◽  
pp. 123-126 ◽  
Author(s):  
S.N. Schiffmann ◽  
E. Teugels ◽  
P. Halleux ◽  
R. Menu ◽  
J.-J. Vanderhaeghen
Keyword(s):  
Spinal Cord ◽  
Dorsal Root Ganglia ◽  
Dorsal Root ◽  
Rat Spinal Cord ◽  
Mrna Detection ◽  
Dorsal Root Ganglia Neurons
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