Insoluble human plasma protein immunoadsorbents. Large-scale production and storage

1977 ◽  
Vol 74 (3) ◽  
pp. 237-245 ◽  
Author(s):  
Samuel T. Nerenberg ◽  
Rameshwar Prasad ◽  
Nancy Biskup ◽  
Linda Pedersen (Demarco)
Keyword(s):  
Human Plasma ◽  
Plasma Protein ◽  
Large Scale ◽  
Scale Production ◽  
Human Plasma Protein ◽  
Large Scale Production ◽  
And Storage

scholarly journals Metal-Organic Frameworks for Metal-Ion Batteries: Towards Scalability

2021 ◽  
Vol 8 (3) ◽  
pp. 20210304
Author(s):  
Semyon Bachinin ◽  
Venera Gilemkhanova ◽  
Maria Timofeeva ◽  
Yuliya Kenzhebayeva ◽  
Andrei Yankin ◽  
...  
Keyword(s):  
Material Science ◽  
Metal Ion ◽  
Large Scale ◽  
Gas Adsorption ◽  
Metal Organic Frameworks ◽  
Scale Production ◽  
Structural Elements ◽  
Large Scale Production ◽  
Metal Organic ◽  
And Storage

Metal-organic frameworks (MOFs), being a family of highly crystalline and porous materials, have attracted particular attention in material science due to their unprecedented chemical and structural tunability. Next to their application in gas adsorption, separation, and storage, MOFs also can be utilized for energy transfer and storage in batteries and supercapacitors. Based on recent studies, this review describes the latest developments about MOFs as structural elements of metal-ion battery with a focus on their industry-oriented and large-scale production.

scholarly journals Underground heat mine – potential for large scale production and storage of thermal energy

2021 ◽  
Vol 703 (1) ◽  
pp. 012034
Author(s):  
L Ahonen ◽  
J Hietava ◽  
K Korhonen ◽  
A Martinkauppi ◽  
K Piipponen
Keyword(s):  
Thermal Energy ◽  
Large Scale ◽  
Scale Production ◽  
Large Scale Production ◽  
And Storage

Large-Scale Production and Properties of a Solvent-Detergent-Treated Factor IX Concentrate from Human Plasma

Vox Sanguinis ◽  
1988 ◽  
Vol 55 (4) ◽  
pp. 202-210 ◽  
Author(s):  
C. Michalski ◽  
F. Bal ◽  
T. Burnouf ◽  
M. Goudemand
Keyword(s):  
Human Plasma ◽  
Large Scale ◽  
Factor Ix ◽  
Scale Production ◽  
Large Scale Production

scholarly journals Preparation of factor IX deficient human plasma by immunoaffinity chromatography using a monoclonal antibody

Blood ◽  
1982 ◽  
Vol 59 (3) ◽  
pp. 664-670 ◽  
Author(s):  
AH Goodall ◽  
G Kemble ◽  
DP O'Brien ◽  
E Rawlings ◽  
F Rotblat ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Human Plasma ◽  
Large Scale ◽  
High Capacity ◽  
Factor Ix ◽  
Affinity Column ◽  
Scale Production ◽  
Large Scale Production ◽  
Normal Human ◽  
Coagulation Assay

Abstract A murine hybridoma clone is described that grows continuously in culture and produces a monoclonal antibody we have called Royal Free Monoclonal Antibody to factor IX No. 1 (RFF-IX/1). This has high affinity for a coagulation site on factor IX. RFF-IX/1 immobilised on sepharose can be used to deplete factor IX from normal human plasma. This immunoaffinity depleted plasma is indistinguishable from severe Christmas disease plasma and can be used as the substrate in a one stage coagulation assay for factor IX. The affinity column has high capacity and can be regenerated so that large scale production from normal plasma of factor IX deficient plasma as a diagnostic reagent is now feasible.

Large-scale production and properties of human plasma-derived activated Factor VII concentrate

Vox Sanguinis ◽  
2003 ◽  
Vol 84 (1) ◽  
pp. 54-64 ◽  
Author(s):  
K. Tomokiyo ◽  
H. Yano ◽  
M. Imamura ◽  
Y. Nakano ◽  
T. Nakagaki ◽  
...  
Keyword(s):  
Human Plasma ◽  
Large Scale ◽  
Factor Vii ◽  
Scale Production ◽  
Activated Factor Vii ◽  
Large Scale Production

scholarly journals Preparation of factor IX deficient human plasma by immunoaffinity chromatography using a monoclonal antibody

Blood ◽  
1982 ◽  
Vol 59 (3) ◽  
pp. 664-670
Author(s):  
AH Goodall ◽  
G Kemble ◽  
DP O'Brien ◽  
E Rawlings ◽  
F Rotblat ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Human Plasma ◽  
Large Scale ◽  
High Capacity ◽  
Factor Ix ◽  
Affinity Column ◽  
Scale Production ◽  
Large Scale Production ◽  
Normal Human ◽  
Coagulation Assay

A murine hybridoma clone is described that grows continuously in culture and produces a monoclonal antibody we have called Royal Free Monoclonal Antibody to factor IX No. 1 (RFF-IX/1). This has high affinity for a coagulation site on factor IX. RFF-IX/1 immobilised on sepharose can be used to deplete factor IX from normal human plasma. This immunoaffinity depleted plasma is indistinguishable from severe Christmas disease plasma and can be used as the substrate in a one stage coagulation assay for factor IX. The affinity column has high capacity and can be regenerated so that large scale production from normal plasma of factor IX deficient plasma as a diagnostic reagent is now feasible.

Large Scale Production of Human Plasma Fractions

Vox Sanguinis ◽  
1962 ◽  
Vol 7 (4) ◽  
pp. 414-424 ◽  
Author(s):  
P. Kistler ◽  
Hs. Nitschmann
Keyword(s):  
Human Plasma ◽  
Large Scale ◽  
Scale Production ◽  
Large Scale Production ◽  
Plasma Fractions

High-yield amplification ofCryptosporidium parvumin interferon γ receptor knockout mice

Parasitology ◽  
2008 ◽  
Vol 135 (10) ◽  
pp. 1151-1156 ◽  
Author(s):  
J. von OETTINGEN ◽  
M. NATH-CHOWDHURY ◽  
B. J. WARD ◽  
A. C. RODLOFF ◽  
M. J. ARROWOOD ◽  
...  
Keyword(s):  
Large Scale ◽  
Interferon Γ ◽  
High Yield ◽  
Scale Production ◽  
Large Scale Production ◽  
Ether Extraction ◽  
External Sources ◽  
And Storage

SUMMARYTo date, large-scale production ofCryptosporidium parvumoocysts has only been achieved by amplification in neonatal calves and sheep. Many laboratories currently depend on supplies from external sources and store oocysts for prolonged periods which results in progressive loss of viability. Six to 8-week-old interferon γ receptor knockout (IFNγR-KO) mice on a C57BL/6 background were inoculated by gavage (2000 oocysts/animal). Fecal pellets were collected daily from 7 days post-infection (p.i.) up to 2 weeks p.i. Intestinal oocyst yield was assessed at days 11, 12 and 14 p.i. by homogenization of intestinal tissues. Ether extraction and one or more NaCl flotations were used to purify oocysts. Total recoveries averaged 2·6×106oocysts/mouse from fecal material and 3·8×107oocysts/mouse from intestinal tissues. Overall, 2·3×109purified oocysts were obtained from 60 mice. Recovered oocysts were capable of sporulation and were shown to be infectious bothin vitroandin vivo. Oocyst amplification was achieved in only 11–14 days with minimal expense. The simplicity of this method presents a practical alternative for the routine passage, maintenance and storage ofC. parvumin biomedical laboratories.

Large Scale Production of Human Plasma Fractions

Vox Sanguinis ◽  
1962 ◽  
Vol 7 (4) ◽  
pp. 414-424 ◽  
Author(s):  
P. Kistler ◽  
Hs. Nitschmann
Keyword(s):  
Human Plasma ◽  
Large Scale ◽  
Scale Production ◽  
Large Scale Production ◽  
Plasma Fractions
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